American Journal of Kidney Diseases
Volume 40, Issue 1 , Pages 104-109 , July 2002

Factors contributing to higher hematocrit levels in hemodialysis patients not receiving recombinant human erythropoietin

Received 24 September 2001 ,Revised 22 March 2002 ,Accepted 22 March 2002.

References 

  1. Fisher JW. Mechanism of the anemia of chronic renal failure. Nephron. 1980;25:106–111
  2. Sundal E, Kaeser U. Correction of anemia of chronic renal failure with recombinant human erythropoietin: Safety and efficacy of one year's treatment in a European Multicenter Study of 150 patients. Nephrol Dial Transplant. 1989;4:979–987
  3. Suzuki M. Analysis of the factors in the cases resistant to recombinant human erythropoietin treatment. Contrib Nephrol. 1990;82:65–71
  4. MacDougall IC. Poor response to erythropoietin. BMJ. 1989;310:1424–1425
  5. Study Group WHO. Diet, nutrition, and the prevention of chronic diseases. World Health Organ Tech Res Ser. 1990;797:69–74
  6. National Kidney Foundation . K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease. Am J Kidney Dis. 2001;37(suppl 1):S182–S238
  7. Working Party for European Best Practice Guidelines for the Management of Anemia in Patients With Chronic Renal Failure . European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant. 1999;14(suppl 5):S1–S50
  8. Goldsmith HJ, Ahmad R, Raichura N, et al.  Association between rising haemoglobin concentration and renal cyst formation in patients on long term regular haemodialysis treatment. Proc EDTA. 1982;19:313–318
  9. Ishikawa I. Uremic acquired cystic disease of kidney. Urology. 1985;26:101–108
  10. Akiba T, Nakai S, Shinzato T, et al.  Why has the gross mortality of dialysis patients increased in Japan?. Kidney Int. 2000;57(suppl 74):S60–S65
  11. Chandra M, Miller ME, Garcia JF, Mossey RT, McVicar M. Serum immunoreactive erythropoietin levels in patients with polycystic kidney disease as compared with other hemodialysis patients. Nephron. 1985;39:26–29
  12. Eckardt K-U, Mollmann M, Neumann R, et al.  Erythropoietin in polycystic kidneys. J Clin Invest. 1989;84:1160–1166
  13. Madore F, Lowrie EG, Brugnara C, et al.  Anemia in hemodialysis patients: Variables affecting this outcome predictor. J Am Soc Nephrol. 1997;8:1921–1929
  14. Goicoechea M, Martin J, Sequera P, et al.  Role of cytokines in the response to erythropoietin in hemodialysis patients. Kidney Int. 1998;54:1337–1343
  15. Zhang Y, Proenca R, Maffei M, Barone M, Lori L, Friedian JM. Positional cloning of the mouse gene and its human homologie. Nature. 1994;372:425–432
  16. Cosidine RV, Sinha MK, Heiman MK, et al.  Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–295
  17. Larsson H, Elmstahl S, Ahren B. Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women. Diabetes. 1996;45:1580–1584
  18. Nishizawa Y, Shoji T, Tanaka S, et al.  Plasma leptin level and its relationship with body composition in hemodialysis patients. Am J Kidney Dis. 1998;31:655–661
  19. Heimburger O, Lonnqvist F, Danielsson A, Nordenstrom J, Stenvinkel P. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol. 1997;8:1423–1430
  20. Dagogo-Jack S, Ovalle F, Geary B, Landt M, Cotne DW. Hyperleptinemia in patients with end-stage renal disease treated by continuous ambulatory peritoneal dialysis. Perit Dial Int. 1998;18:34–40
  21. Cioffi JA, Shafer AW, Zupancic TJ, et al.  Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat Med. 1996;2:585–589
  22. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. A role for leptin and its cognate receptor in hematopoiesis. Curr Biol. 1996;6:1170–1180
  23. Mikhall AA, Beck EX, Zupancic TJ, et al.  Leptin stimulates fetal and adult erythroid myeloid development. Blood. 1997;5:1507–1512
  24. Stenvinkel P, Heimburger O, Lonnqvist F, Barany P. Does the ob gene product leptin stimulate erythropoiesis in patients with chronic renal failure?. Kidney Int. 1998;53:1430–1431
  25. Shih LY, Huang JY, Lee CT. Insulin-like growth factor I plays a role in regulating erythropoiesis in patients with end-stage renal disease and erythrocytosis. J Am Soc Nephrol. 1999;10:315–322
  26. Morrone LF, Paolo SD, Logoluso F, et al.  Interference of angiotensin-converting enzyme inhibitors on erythropoiesis in kidney transplant recipients. Transplantation. 1997;64:913–918
  27. Kopple JD, Zhu X, Lew XZ, Lowrie EG. Body weight-for-height relationship predicts mortality in maintenance hemodialysis patients. Kidney Int. 1999;56:1136–1148
  28. Fleischmann E, Treal N, Dudley J, May W, Bower JD, Salahudeen KS. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int. 1999;55:1560–1567
  29. Wolfe RA, Ashby VB, Daugirdas JT, Agodoa LYC, Jones CA, Port FK. Body size, dose of hemodialysis, and mortality. Am J Kidney Dis. 2000;35:80–88

☆ Supported in part by a grant from the Society for Research of Renal Anemia.

☆☆ Address reprint requests to Atsushi Takeda, MD, Kidney Center, Tsuchiura Kyodo General Hospital, 11-7, Manabe shinmachi, Tsuchiura-shi, Ibaraki-ken, 300-0053, Japan. E-mail: takedas@d5.dion.ne.jp

★ 0272-6386/02/4001-0013$35.00/0

PII: S0272-6386(02)00013-6

doi: 10.1053/ajkd.2002.33918

American Journal of Kidney Diseases
Volume 40, Issue 1 , Pages 104-109 , July 2002

Article Tools

* Image Usage & Resolution