American Journal of Kidney Diseases
Volume 40, Issue 2 , Pages 221-226 , August 2002

Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis

Received 11 February 2002 ,Revised 4 April 2002 ,Accepted 4 April 2002.

References 

  1. Bostom AG, Dworkin LD. Cystatin C measurement: Improved detection of mild decrements in glomerular filtration rate versus creatinine-based estimates?. Am J Kidney Dis. 2000;36:205–207
  2. Price CP, Finney H. Developments in the assessment of glomerular filtration rate. Clin Chim Acta. 2000;297:55–66
  3. Nilsson-Ehle P, Grubb A. New markers for the determination of GFR: Iohexol clearance and cystatin C serum concentration. Kidney Int. 1994;47(suppl 47):S17–S19
  4. Grubb AO. Cystatin C—Properties and use as diagnostic marker. Adv Clin Chem. 2000;35:63–99
  5. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol. 1992;38(suppl 1):S20–S27
  6. Grubb A, Simonsen O, Sturfelt G, Truedsson L, Thysell H. Serum concentration of cystatin C, factor D and beta 2-microglobulin as a measure of glomerular filtration rate. Acta Med Scand. 1985;218:499–503
  7. Simonsen O, Grubb A, Thysell H. The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate. Scand J Clin Lab Invest. 1985;45:97–101
  8. Woitas RP, Stoffel-Wagner B, Flommersfeld S, et al.  Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis. Clin Chem. 2000;46:712–715
  9. Newman DJ, Thakkar H, Edwards RG, et al.  Serum cystatin C measured by automated immunoassay: A more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 1995;47:312–318
  10. Risch L, Blumberg A, Huber A. Rapid and accurate assessment of glomerular filtration rate in patients with renal transplants using serum cystatin C. Nephrol Dial Transplant. 1999;14:1991–1996
  11. Harmoinen AP, Kouri TT, Wirta OR, et al.  Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes. Clin Nephrol. 1999;52:363–370
  12. Plebani M, Dall'Amico R, Mussap M, et al.  Is serum cystatin C a sensitive marker of glomerular filtration rate (GFR)? A preliminary study on renal transplant patients. Ren Fail. 1998;20:303–309
  13. Priem F, Althaus H, Jung K, Sinha P. Beta-trace protein is not better than cystatin C as an indicator of reduced glomerular filtration rate. Clin Chem. 2001;47:2181
  14. Thomassen S, Johannesen IL, Erlandsen EJ, Abrahamsen J, Randers E. Serum cystatin C as a marker of the renal function in patients with spinal cord injury. J Am Soc Nephrol. 2001;12:252A; (abstr)
  15. Kyhse-Andersen J, Schmidt C, Nordin G, et al.  Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem. 1994;40:1921–1926
  16. Donadio C, Lucchesi A, Ardini M, Giordani R, Cystatin C. beta 2-microglobulin, and retinol-binding protein as indicators of glomerular filtration rate: Comparison with plasma creatinine. J Pharm Biomed Anal. 2001;24:835–842
  17. Coll E, Botey A, Alvarez L, et al.  Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29–34
  18. Oddoze C, Morange S, Portugal H, Berland Y, Dussol B. Cystatin C is not more sensitive than creatinine for detecting early renal impairment in patients with diabetes. Am J Kidney Dis. 2001;38:310–316
  19. Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population. Clin Chem. 1998;44:1334–1338
  20. van Essen GG, Stegeman CA, Apperloo AJ, Rensma PL, de Zeeuw D, de Jong PE. Serum cystatin C is not superior to creatinine based methods to estimate GFR during long term follow up. J Am Soc Nephrol. 1997;8:79A; (abstr)
  21. Coll E, Botey A, Alvarez L, Piera C, Darnell A, Poch E. In reply: Serum cystatin as a marker of glomerular filtration rate. Am J Kidney Dis. 2001;37:450
  22. Parvex PM, Grey V, Tange S, Bell L. Is cystatin C a simple measure of glomerular filtration rate in children?. J Am Soc Nephrol. 2001;12:82A; (abstr)
  23. Kazama JJ, Kutsuwada K, Maruyama H, Narita I, Gejyo F, Sauto K. Serum cystatin C level indicates glomerular filtration rate with a better specificity to detect renal dysfunction than 24 hr CCr. J Am Soc Nephrol. 1999;10:170A; (abstr)
  24. Puliyanda D, Rifai N, Farrow G, Herrin JT, Somers MJG. Cystatin C as a marker of glomerular filtration in children. J Am Soc Nephrol. 1999;10:149A; (abstr)
  25. Nakai K, Kikuchi M, Saito K, Nakai K, Itoh C. Practical use of cystatin C measurement as a sensitive and specific marker of GFR change. J Am Soc Nephrol. 1999;10:112A; (abstr)
  26. Uzun H, Ataman R, Kalender B, et al.  Serum cystatin C level in healthy adults and in patients with renal failure. J Am Soc Nephrol. 2001;12:87A; (abstr)
  27. Zitta S, Auprich M, Holzer H, Reibnegger G. Cystatin C concentration and glomerular filtration rate. Lancet. 2001;357:635
  28. Ylinen EA, Ala-Houhala M, Harmoinen AP, Knip M. Cystatin C as a marker for glomerular filtration rate in pediatric patients. Pediatr Nephrol. 1999;13:506–509
  29. Vinge E, Lindergard B, Nilsson-Ehle P, Grubb A. Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scand J Clin Lab Invest. 1999;59:587–592
  30. Tian S, Kusano E, Ohara T, et al.  Cystatin C measurement and its practical use in patients with various renal diseases. Clin Nephrol. 1997;48:104–108
  31. Randers E, Erlandsen EJ, Pedersen OL, Hasling C, Danielsen H. Serum cystatin C as an endogenous parameter of the renal function in patients with normal to moderately impaired kidney function. Clin Nephrol. 2000;54:203–209
  32. Randers E, Kristensen JH, Erlandsen EJ, Danielsen H. Serum cystatin C as a marker of the renal function. Scand J Clin Lab Invest. 1998;58:585–592
  33. Paskalev E, Lambreva L, Simeonov P, et al.  Serum cystatin C in renal transplant patients. Clin Chim Acta. 2001;310:53–56
  34. Page MK, Bukki J, Luppa P, Neumeier D. Clinical value of cystatin C determination. Clin Chim Acta. 2000;297:67–72
  35. Meier P, Froidevaux C, Dayer E, Blanc E. Serum concentration of cystatin C as a rapid estimation of the renal function. J Am Soc Nephrol. 1999;10:82A; (abstr)
  36. Le Bricon T, Thervet E, Froissart M, et al.  Plasma cystatin C is superior to 24-h creatinine clearance and plasma creatinine for estimation of glomerular filtration rate 3 months after kidney transplantation. Clin Chem. 2000;46:1206–1207
  37. Le Bricon T, Thervet E, Benlakehal M, Bousquet B, Legendre C, Erlich D. Changes in plasma cystatin C after renal transplantation and acute rejection in adults. Clin Chem. 1999;45:2243–2249
  38. Jung K, Jung M. Cystatin C: A promising marker of glomerular filtration rate to replace creatinine. Nephron. 1995;70:370–371
  39. Herget-Rosenthal S, Trabold S, Pietruck F, Holtmann M, Philipp T, Kribben A. Cystatin C: Efficacy as screening test for reduced glomerular filtration rate. Am J Nephrol. 2000;20:97–102
  40. Herget-Rosenthal S, Trabold S, Huesing J, Heemann U, Philipp T, Kribben A. Cystatin C—An accurate marker of glomerular filtration rate after renal transplantation?. Transpl Int. 2000;13:285–289
  41. Helin I, Axenram M, Grubb A. Serum cystatin C as a determinant of glomerular filtration rate in children. Clin Nephrol. 1998;49:221–225
  42. Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis. 2001;37:79–83
  43. Filler G, Priem F, Vollmer I, Gellermann J, Jung K. Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol. 1999;13:501–505
  44. Filler G, Witt I, Priem F, Ehrich JH, Jung K. Are cystatin C and beta 2-microglobulin better markers than serum creatinine for prediction of a normal glomerular filtration rate in pediatric subjects?. Clin Chem. 1997;43:1077–1078
  45. Erlandsen EJ, Randers E, Kristensen JH. Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scand J Clin Lab Invest. 1999;59:1–8
  46. Demirtas S, Bozbas A, Akbay A, Yavuz Y, Karaca L. Diagnostic value of serum cystatin C for evaluation of hepatorenal syndrome. Clin Chim Acta. 2001;311:81–89
  47. Chantrel F, Agin A, Offner M, Koehl C, Moulin B, Hannedouche T. Comparison of cystatin C versus creatinine for detection of mild renal failure. Clin Nephrol. 2000;54:374–381
  48. Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C—A new marker of glomerular filtration rate in children independent of age and height. Pediatrics. 1998;101:875–881
  49. Greiner M, Pfeiffer D, Smith RD. Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Prev Vet Med. 2000;45:23–41
  50. Farr BM, Shapiro DE. Diagnostic tests: Distinguishing good tests from bad and even ugly ones. Infect Control Hosp Epidemiol. 2000;21:278–284
  51. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39:561–577
  52. Pergande M, Jung K. Sandwich enzyme immunoassay of cystatin C in serum with commercially available antibodies. Clin Chem. 1993;39:1885–1890

 Address reprint requests to Vikas R. Dharnidharka, MD, Assistant Professor, Division of Pediatric Nephrology, University of Florida Health Science Center, 1600 SW Archer Rd, PO Box 100296, Gainesville FL 32610-0296. E-mail: vikasmd@peds.ufl.edu

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doi: 10.1053/ajkd.2002.34487

American Journal of Kidney Diseases
Volume 40, Issue 2 , Pages 221-226 , August 2002