American Journal of Kidney Diseases
Volume 39, Issue 2 , Pages 257-265 , February 2002

Effects of exercise training plus normalization of hematocrit on exercise capacity and health-related quality of life

Received 29 May 2001 ,Revised 31 August 2001 ,Accepted 31 August 2001.

References 

  1. Office of the US Surgeon General, Physical Activity and Health . A Report of the Surgeon General. US Department of Health and Human Services, Public Health Service; 1996;
  2. Painter PL, Moore GEM. The impact of r-HuErythropoeitin on exercise capacity in hemodialysis patients. Adv Ren Replace Ther. 1994;1:55–65
  3. Painter P. Exercise in end stage renal disease. Exer Sport. Sci Rev. 1988;16:305–339
  4. Guthrie M, Cardenas D, Eschbach JW, Haley NR, Robertson HT, Evans RW. Effects of erythropoietin on strength and functional status of patients on hemodialysis. Clin Nephrol. 1993;2:97–102
  5. Lundin AP, Stein RA, Frank F. Cardiovascular status in long-term hemodialysis patients: An exercise and echocardiographic study. Nephron. 1981;28:234–238
  6. Mayer G, Thum J, Cada E, Stummvoll HK, Graf H. Working capacity is increased following recombinant human erythropoietin treatment. Kidney Int. 1988;34:525–528
  7. Moore GE, Brinker KR, Stray-Gundersen J, Mitchell JH. Determinants of VO2peak in patients with end-stage renal disease: On and off dialysis. Med Sci Sports Exerc. 1993;25:18–23
  8. Painter PL, Messer-Rehak D, Hanson P, Zimmerman S, Glass NR. Exercise capacity in hemodialysis, CAPD and renal transplant patients. Nephron. 1986;42:47–51
  9. Painter PL. Exercise training during dialysis: Participation rates. Dial Transplant. 1988;17:165
  10. Robertson HT, Haley NR, Guthrie M. Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients. Am J Kidney Dis. 1990;15:325–332
  11. Shalom R, Blumenthal JA, Williams RS. Feasibility and benefits of exercise training in patients on maintenance dialysis. Kidney Int. 1984;25:958–963
  12. Zabetakis PM, Gleim GW, Pasternak FL, Saraniti A, Nicholas JA, Michelis MF. Long-duration submaximal exercise conditioning in hemodialysis patients. Clin Nephrol. 1982;8:17–22
  13. Barnea N, Drory Y, Iaina A, Lapidot C, Reisin E, Eliahou H, et al. Exercise tolerance in patients on chronic hemodialysis. Isr J Med Sci. 1980;16:17–21
  14. Metra M, Cannella G, LaCanna G, Guaini T, Sandrini M, Gaggiotti M, et al. Improvement in exercise capacity after correction of anemia in patients with end stage renal failure. Am J Cardiol. 1991;68:1060–1066
  15. Lundin AP, Ackerman MJ, Chesler RM, Delano BG, Goldberg N, Stein RA, et al. Exercise in hemodialysis patients after treatment with recombinant human erythropoietin. Nephron. 1991;58:315–319
  16. Clyne N, Jogestrand T. Effect of erythropoietin treatment on physical exercise capacity and renal function in predialytic uremic patients. Nephron. 1992;60:390–396
  17. Moore GE. Integrated gas exchange responses in chronic renal failure. In:  Roca J,  Rodriques-Roisin R,  Wagner PD editor. Pulmonary and Peripheral Gas Exchange in Health and Disease. New York: Marcel-Dekker, Inc; 2000;
  18. Painter P. The importance of exercise training in rehabilitation of patients with end stage renal disease. Am J Kidney Dis. 1994;24(suppl 1):S2–S9
  19. American College of Sports Medicine . Guidelines for Exercise Testing and Prescription. ed 5. Philadelphia: Williams & Wilkins; 1995;
  20. Stewart AL, Ware JEJ. Measuring Functioning and Well-being: The Medical Outcomes Study Approach. Durham, NC: Duke University Press; 1992;
  21. Ware J. SF-36 Health Survey: Manual and Interpretation Guide. Boston: The Health Institute; 1993;
  22. Ware JE, Kosinski M, Keller SD. SF-36 Physical and Mental Health Summary Scales: A User's Manual. ed 2. Boston, MA: Health Institute; 1994;
  23. Stray-Gunderson J, Sams B, Goodkind D, Holloway D, Wang C, Thompson J. Improvement in functional capacity in dialysis patients with regular exercise and correction of anemia. J Am Soc Nephrol. 1997;9:212A; (abstr)
  24. McMahon LP, McKenna MJ, Sangkabutra T, Mason K, Sostaric S, Skinner SL, et al. Physical performance and associated electrolyte changes after haemoglobin normalization: A comparative study in haemodialysis patients. Nephrol Dial Transplant. 1999;14:1182–1187
  25. Ross DL, Grabeau GM, Smith S, Seymour M, Knierim N, Pitetti KH. Efficacy of exercise for end-stage renal disease patients immediately following high-efficiency hemodialysis: A pilot study. Am J Nephrol. 1989;9:376–383
  26. Goldberg AP, Hagberg JM, Delmez JA, Carney RM, McKevitt P, Ehsani AA, et al. The metabolic and psychological effects of exercise training in hemodialysis patients. Am J Clin Nutr. 1980;33:1620–1628
  27. Johansen KL. Physical functioning and exercise capacity in patients on dialysis. Adv Ren Replace Ther. 1999;6:141–148
  28. Akiba T, Matsui N, Shinohara S, Fujiwara H, Nomura T, Marumo F. Effects of recombinant human erythropoietin and exercise training on exercise capacity in hemodialysis patients. Artif Organs. 1995;19:1262–1268
  29. Marrades R, Roca J, Campistol J, Diaz O, Barbera JA, Torregrosa JV, et al. Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure. J Clin Invest. 1996;97:2092–2100
  30. MacDougall I, Lewis NP, Saunders MJ, Cochlin DL, Davies ME, Hutton RD, et al. Long-term cardiorespiratory effects of amelioration of renal anemia by erythropoietin. Lancet. 1990;335:489–493
  31. Kouidi E, Albani M, Natsis K, Magalopoulos A, Gigis P, Guiba-Tziampiri O, et al. The effects of exercise training on muscle atrophy in haemodialysis patients. Nephrol Dial Transplant. 1998;13:685–699
  32. Meyer KB, Espindle DM, DeGiacomo JM, Jenuleson CS, Kurtin PS, Davies AR. Monitoring dialysis patients' health status. Am J Kidney Dis. 1994;24:267–279
  33. DeOreo PB. Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization and dialysis-attendance compliance. Am J Kidney Dis. 1997;30:204–212
  34. Painter PL, Carlson L, Carey S, Paul SM, Myll J. Physical functioning and health related quality of life changes with exercise training in hemodialysis patients. Am J Kidney Dis. 2000;35:482–492
  35. Painter PL, Carlson L, Carey S, Paul SM, Myll J. Low functioning patients improve with exercise training. Am J Kidney Dis. 2000;36:600–608
  36. Lowrie EG, Zhang H, LePaine N, Lew NL, Lazarus JM. Health related quality of life (QoL) among dialysis patients: Associations with contemporaneous measures and future mortality. J Am Soc Nephrol. 1998;9:219A; (abstr)
  37. Painter PL, Stewart AL, Carey S. Physical functioning: Definitions, measurement, and expectations. Adv Ren Replace Ther. 1999;6:110–123

 Supported by Amgen, Inc. Work performed at the Stanford Center for Research in Disease Prevention.

☆☆ Address reprint requests to Patricia Painter, PhD, UCSF Department of Physiological Nursing, Box 0116, San Francisco, CA 94143. E-mail: Painter@itsa.ucsf.edu

 0272-6386/02/3902-0003$35.00/0

PII: S0272-6386(02)09189-8

American Journal of Kidney Diseases
Volume 39, Issue 2 , Pages 257-265 , February 2002