American Journal of Kidney Diseases
Volume 43, Issue 4 , Pages 663-670 , April 2004

A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome

  • James A. Sloand, MD

      Affiliations

    • Department of Medicine, Nephrology Division, University of Rochester School of Medicine, Rochester, NY, USA
    • Corresponding Author InformationAddress reprint requests to James A. Sloand, MD, Nephrology Division, Highland Hospital, 1000 South Ave, Rochester, NY 14620 USA
    • ,
  • Mark A. Shelly, MD

      Affiliations

    • Department of Medicine, Nephrology Division, University of Rochester School of Medicine, Rochester, NY, USA
    • Department of Medicine, Infectious Disease Division, University of Rochester, Rochester, NY, USA
    • Department of Neurology, Movement Disorder Center, North Shore-Long Island Jewish Research Institute, New Hyde, NY, USA
    • ,
  • Andrew Feigin, MD

      Affiliations

    • Department of Medicine, Nephrology Division, University of Rochester School of Medicine, Rochester, NY, USA
    • Department of Medicine, Infectious Disease Division, University of Rochester, Rochester, NY, USA
    • Department of Neurology, Movement Disorder Center, North Shore-Long Island Jewish Research Institute, New Hyde, NY, USA
    • ,
  • Paul Bernstein, MD

      Affiliations

    • Department of Medicine, Nephrology Division, University of Rochester School of Medicine, Rochester, NY, USA
    • Department of Medicine, Infectious Disease Division, University of Rochester, Rochester, NY, USA
    • Department of Neurology, Movement Disorder Center, North Shore-Long Island Jewish Research Institute, New Hyde, NY, USA
    • ,
  • Rebeca D. Monk, MD

      Affiliations

    • Department of Medicine, Nephrology Division, University of Rochester School of Medicine, Rochester, NY, USA
    • Department of Medicine, Infectious Disease Division, University of Rochester, Rochester, NY, USA
    • Department of Neurology, Movement Disorder Center, North Shore-Long Island Jewish Research Institute, New Hyde, NY, USA

Received 30 July 2003 ,Revised 20 November 2003 ,Accepted 20 November 2003.

References 

  1. Roger SD, Harris DCH, Stewart JH. Possible relation between restless legs syndrome and anaemia in renal dialysis patients. Lancet. 1991;337:1551
  2. Holley JL, Nespor S, Rault R. A comparison of sleep disorders in patients on chronic hemodialysis and continuous peritoneal dialysis. Am J Kidney Dis. 1992;19:156–161
  3. Walker S, Fine A, Kryger MH. Sleep complaints are common in a dialysis unit. Am J Kidney Dis. 1995;26:751–758
  4. Winkelman JW, Chertow GM, Lazarus JM. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis. 1996;28:372–378
  5. Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord. 1995;10:634–642
  6. Hening WA, Walters A, Chokroverty S. Movement disorders in sleep. In:  Chokroverty S editors. Movement Disorders. New York, NY: PMA; 1990;p. 136–143
  7. Ekbom KA. Restless legs (A clinical study). Acta Med Scand. 1945;158(suppl):S1–S123
  8. Ekbom KA. Restless legs syndrome. Neurology. 1960;10:868–873
  9. Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and restless legs syndrome. Sleep. 1998;21:371–377
  10. Silber MH, Richardson JW. Multiple blood donations associated with iron deficiency in patients with restless legs syndrome. Mayo Clin Proc. 2003;78:52–54
  11. Barton A, Bowie J, Ebmeier K. Low plasma iron status and akathisia. J Neurol Neurosurg Psychiatry. 1990;53:671–674
  12. Nordlander NB. Therapy in restless legs. Acta Med Scand. 1953;145:453–457
  13. Earley C, Allen R. Peroglide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients. Sleep. 1996;19:801–810
  14. Blake D, Williams A, Pall H, Fonseca A, Beswick T. Iron and akathisia. Br Med J. 1986;292:1393
  15. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology. 2000;54:1698–1700
  16. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56:263–265
  17. Feigin AS, Monk RD, Erenstone A, Sloand JA. Restless legs syndrome in patients with end stage renal disease. Symposia on etiology, pathogenesis, and treatment of Parkinson’s disease and hyperkinetic movement disorders. Mov Disord. 1996;11:608; (abstr)
  18. Walters AS. International Restless Legs Syndrome Study Group. Towards a better definition of the restless legs syndrome. Mov Disord. 1995;10:634–642
  19. Fishbane S, Maesaka JK. Iron management in end-stage renal disease. Am J Kidney Dis. 1997;29:319–333
  20. Zimmerman J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in HD patients. Kidney Int. 1999;55:648–658
  21. Collado-Seidel V, Kohnen R, Samtleben W, Hillebrand GF, Oertel WH, Trenkwalder C. Clinical and biochemical findings in uremic patients with and without restless legs syndrome. Am J Kidney Dis. 1998;31:324–328
  22. Connor JR, Boyer PJ, Menzies SL, et al.  Neuropatho logical examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology. 2003;61:304–309
  23. Davis BJ, Rajput ML, Aul EA, Eichhorn GR. A randomized, double-blind placebo-controlled trial of iron in restless legs syndrome. Eur Neurol. 2000;43:70–75
  24. The International Restless Legs Syndrome Study Group . Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–132
  25. Cirignotta F, Mondini S, Santoro A, Ferrari G, Gerardi R, Buzzi G. Reliability of questionnaire screening restless legs syndrome in patients on chronic dialysis. Am J Kidney Dis. 2002;40:302–306
  26. Earley CJ. Restless legs syndrome. N Engl J Med. 2003;348:2103–2109
  27. Odin P, Mrowka M, Shing M. Restless legs syndrome. Eur J Neurol. 2002;3:59–67
  28. Flowers CM, Racoosin JA, Lu SL, Beitz JG. The US Food and Drug Administration’s registry of patients with pergolide-associated valvular heart disease. Mayo Clin Proc. 2003;78:730–731

PII: S0272-6386(04)00009-5

doi: 10.1053/j.ajkd.2003.11.021

American Journal of Kidney Diseases
Volume 43, Issue 4 , Pages 663-670 , April 2004

Article Tools

* Image Usage & Resolution