American Journal of Kidney Diseases
Volume 44, Issue 3 , Pages 385-401 , September 2004

Immunosuppressive treatment for idiopathic membranous nephropathy: A systematic review

  • Annalisa Perna, StatSciD

      Affiliations

    • Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    • Corresponding Author InformationAddress reprint requests to Annalisa Perna, StatSciD, Clinical Research Centre for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    • ,
  • Arrigo Schieppati, MD

      Affiliations

    • Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    • Nephrology and Dialysis Unit, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • ,
  • Javier Zamora, PhD

      Affiliations

    • Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    • ,
  • Giovanni A. Giuliano, DiplStat

      Affiliations

    • Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    • ,
  • Norbert Braun, MD

      Affiliations

    • Section of Nephrology and Hypertension, University of Tuebingen, Tuebingen, Germany
    • ,
  • Giuseppe Remuzzi, MD

      Affiliations

    • Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    • Nephrology and Dialysis Unit, Ospedali Riuniti di Bergamo, Bergamo, Italy

Received 14 January 2004 ,Accepted 10 May 2004.

References 

  1. Cameron JS . Membranous nephropathy and its treatment . Nephrol Dial Transplant . 1992;7(suppl 1):S72–S79
  2. Schieppati S , Mosconi L , Perna A , et al.   Prognosis of untreated patients with idiopathic membranous nephropathy . N Engl J Med . 1993;329:85–89
  3. Honkanen E , Tornroth T , Grohagen-Riska C . Natural history, clinical course and morphological evolution of membranous nephropathy . Nephrol Dial Transplant . 1992;7(suppl 1):S35–S41
  4. Glassock RJ . The therapy of idiopathic membranous glomerulonephritis . Semin Nephrol . 1991;11:138–147
  5. Couchoud C , Laville M , Boissel JP . Treatment of membranous nephropathy . Nephrol Dial Transplant . 1994;9:469–470
  6. Hogan SL , Muller KE , Jennette JC , Falk RJ . A review of therapeutic studies of idiopathic membranous glomerulopathy . Am J Kidney Dis . 1995;25:862–875
  7. Imperiale TF , Goldfarb S , Berns JS . Are cytotoxic agents beneficial in idiopathic membranous nephropathy? A meta-analysis of the controlled trials . J Am Soc Nephrol . 1995;5:1553–1558
  8. Coggins CH  Collaborative Study of the Adult Idiopathic Nephrotic Syndrome . A controlled study of short-term prednisone treatment in adults with membranous nephropathy . N Engl J Med . 1979;301:1301–1306
  9. Cameron JS , Healy MJR , Adu D . The Medical Research Council trial of short-term high-dose alternate day prednisolone in idiopathic membranous nephropathy with nephrotic syndrome in adults . Q J Med . 1990;274:133–156
  10. Cattran DC , Delmore T , Roscoe J , et al.   A randomized controlled trial of prednisone in patients with idiopathic membranous nephropathy . N Engl J Med . 1989;320:210–215
  11. Donadio JV , Holley KE , Anderson CF , Taylor WF . Controlled trial of cyclophosphamide in idiopathic membranous nephropathy . Kidney Int . 1974;6:431–439
  12. Ponticelli C , Zucchelli P , Imbasciati E , et al.   Controlled trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy . N Engl J Med . 1984;310:946–950
  13. Murphy BF , McDonald I , Fairley KF , Kincaid-Smith PS . Randomised controlled trial of cyclophosphamide, warfarin and dipyridamole in idiopathic membranous glomerulonephritis . Clin Nephrol . 1992;37:229–234
  14. Ponticelli C , Zucchelli P , Passerini P , Cesana B  Italian Idiopathic Membranous Nephropathy Treatment Study Group . Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy . N Engl J Med . 1992;327:599–603
  15. Robinson KA , Dickersin K . Development of a highly sensitive search for the retrieval of reports of controlled trials using PubMed . Int J Epidemiol . 2002;31:150–153
  16. Pahari DK , Das S , Dutta BN , Banerjee D . Prognosis and management of membranous nephropathy . J Assoc Physicians India . 1993;41:350–351
  17. Silverberg DS  Western Canadian Glomerulonephritis Study Group . Controlled trial of azathioprine in the nephrotic syndrome secondary to idiopathic membranous glomerulonephritis . CMAJ . 1976;115:1209–1210
  18. Falk RJ , Hogan SL , Muller KE , Jenette C . Treatment of progressive membranous glomerulopathy . Ann Intern Med . 1992;116:438–445
  19. Ahmed S , Rahman M , Alam MR , et al.   Methyl prednisolone plus chlorambucil as compared with prednisolone alone for the treatment of idiopathic membranous nephropathy. A preliminary study . Bangladesh Ren J . 1994;13:51–54
  20. Branten AJW , Reichert LJM , Koene RAP , Wetzels JFM . Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency . Q J Med . 1998;91:359–366
  21. Cattran DC , Greenwood C , Ritchie S , et al.   A controlled trial of cyclosporine in patients with progressive membranous nephropathy . Kidney Int . 1995;47:1130–1135
  22. Ponticelli C , Altieri P , Scolari F , et al.   A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy . J Am Soc Nephrol . 1998;9:444–450
  23. Reichert LJM , Husmans FTM , Assmann K , Koene RAP , Wetzels JFM . Preserving renal function in patients with membranous nephropathy (Daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide) . Ann Intern Med . 1994;121:328–333
  24. Pisoni R , Grinyo JM , Salvadori M , et al.   Cyclosporine versus conservative therapy in patients with idiopathic membranous nephropathy (IMN) and deteriorating renal function (Results of the CYCLOMEN trial) . J Am Soc Nephrol . 2000;11:95A; (abstr)
  25. Cattran DC , Pohl M , Maxwell D , et al.   Randomized controlled trial of cyclosporine (D) vs . placebo (P) in steroid resistant, nephrotic patients (NS) with membranous nephropathy (SR MGN). J Am Soc Nephrol . 1998;9:85A; (abstr)
  26. Braun N , Erley C , Benda N , et al.   Therapy of membranous glomerulonephritis with nephrotic syndrome. 5 Years follow-up of a prospective, randomised multi-centre study . Nephrol Dial Transplant . 1995;10:967; (abstr)
  27. Tognoni G , Mallick N . (Another) registry of clinical trials? . J Nephrol . 1993;6:117
  28. Current Controlled Trials Ltd. The metaRegister of Controlled Trials (mRCT). Available at: http://www.controlled-trials.com. Accessed: November 24, 2003
  29. Protocol Review, The Lancet. Available at: http://www.thelancet.com/authorinfo/Protocol+review. Accessed: November 24, 2003
  30. Cattran DC , Appel GB , Hebert LA , et al.   Cyclosporine in patients with steroid-resistant membranous nephropathy (A randomised trial) . Kidney Int . 2001;59:1484–1490
  31. Schulz KF , Chalmers I , Grimes DA , Altman DG . Assessing the quality of randomization from reports of controlled trials published in obstetrics and gynecology journals . JAMA . 1994;272:125–128
  32. Marx BE , Marx M . Prognosis of idiopathic membranous nephropathy (A methodologic meta-analysis) . Kidney Int . 1997;51:873–879
  33. Ponticelli C , Zucchelli P , Passerini P , et al.   A randomized trial of methylprednisone and chlorambucil in idiopathic membranous nephropathy . N Engl J Med . 1989;320:8–13
  34. Ambalavanan S , Fauvel J-P , Sibley RK , Myers BD . Mechanism of the antiproteinuric effect of cyclosporine in membranous nephropathy . J Am Soc Nephrol . 1996;7:290–298
  35. Lagrue G , Bernard D , Bariety J , Druet P , Guenel J . Traitement par le chlorambucil et l’azathioprine dans les glomérulonéphrites primitives (Résultats d’une étude “controlée”) . J Urol Nephrol . 1975;81:655–672
  36. Medical Research Council Working Party . Controlled trial of azathioprine and prednisone in chronic renal disease . Br Med J . 1971;2:239–241
  37. Nand N , Das R , Jaswal TS . Evaluation of efficacy of methylprednisolone, prednisolone and chlorambucil in idiopathic glomerulonephritis . J Indian Med Assoc . 1997;95:163–165
  38. Tejani A , Suthanthiran M , Pomrantz A . A randomized controlled trial of low-dose prednisone and cyclosporin versus high-dose prednisone in nephrotic syndrome of children . Nephron . 1991;59:96–99
  39. Yao X , Chen H , Wang Q , et al.   Cyclosporin A treatment for idiopathic membranous nephropathy . Chin Med J . 2001;114:1305–1308
  40. Imbasciati E , Cagnoli L , Case N , et al.   Studio controllato di un trattamento a mesi alterni di steroidi e clorambucil nella nefropatia membranosa e nella glomerulosclerosi focale. Valutazione preliminare dei risultati . Minerva Nefrol . 1980;27:571–575
  41. Ponticelli C , Zucchelli P , Imbasciati E , et al.   Controlled trial of monthly alternated courses of steroid and chlorambucil for idiopathic membranous nephropathy . Proc Eur Dial Transplant Assoc . 1983;19:717–723
  42. Ponticelli C , Zucchelli P , Passerini P , et al.   A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy . Kidney Int . 1995;48:1600–1604
  43. Dickersin K, Min YI: NIH clinical trials and publication bias. On-line J Curr Clin Trials [serial on line]. Apr 28, 1993; doc 50
  44. Lewis EJ , Hunsicker LG , Bain RP , Rohde RD  Collaborative Study Group . The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy . N Engl J Med . 1993;329:1456–1462
  45. Rayner BL , Byrne MJ , van Zyl Smit R . A prospective clinical trial comparing the treatment of idiopathic membranous nephropathy and nephrotic syndrome with simvastatin and diet, versus diet alone . Clin Nephrol . 1996;46:219–224
  46. Olbricht CJ , Wanner C , Thiery J , Basten A  Simvastatin in Nephrotic Syndrome Study Group. . Simvastatin in nephrotic syndrome . Kidney Int . 1999;(Suppl 71):S113–S116
  47. Stegeman CA , De Zeeuw D , De Jong PE . A randomized multicentre trial to compare the effect of symptomatic antiproteinuric treatment with an ACE inhibitor to an immunosuppressive regimen with corticosteroids and of no treatment on the course of membranous nephropathy . J Nephrol . 1994;7:294–300
  48. National Institute of Diabetes and Digestive and Kidney Diseases . A phase II randomized, double-blind, placebo-controlled study of the effect of h5G1.1-mAb on the reduction of proteinuria in patients with idiopathic membranous glomerulopathy . 2001; http://clinicalstudies.info.nih.gov/detail/A_2000-DK-0126.html. Accessed: June 29
  49. Austin AH . Membranous nephropathy . Ann Intern Med . 1992;116:672–682
  50. Austin AH , Vaughan EM , Boumpas DT , Balow JE . Randomized trial of pulse cyclophosphamide and prednisone vs. prednisone alone in idiopathic membranous nephropathy . J Am Soc Nephrol . 1996;7:1327; (abstr)
  51. Jha V , Kohli HS , Sud K , Gupta KL , Joshi K , Sakhuja V . A randomized controlled trial of steroids and cyclophosphamide in adults with idiopathic membranous nephropathy . J Am Soc Nephrol . 2001;213A; (abstr)
  52. Branten AJ , du Buf Vereijken PW , Wetzel JF . Defining the optimal time of treatment start in patients with membranous nephropathy (A randomized study) . J Am Soc Nephrol . 2002;668A; (abstr)
  53. Schieppati A , Perna A , Remuzzi G . Recent developments in the management of membranous nephropathy . Exp Opin Invest Drugs . 1997;6:521–532
  54. Remuzzi G , Chiurchiu C , Abbate M , Brusegan V , Bontempelli M , Ruggenenti P . Rituximab for idiopathic membranous nephropathy . Lancet . 2002;360:923–924
  55. Ruggenenti P , Chiurchiu C , Brusegan V , et al.   Rituximab in idiopathic membranous nephropathy (A one-year prospective study) . J Am Soc Nephrol . 2003;14:1851–1857
  56. Berg AL , Nilsson-Ehle P , Arnadottir M . Beneficial effects of ACTH on the serum lipoprotein profile and glomerular function in patients with membranous nephropathy . Kidney Int . 1999;56:1534–1543
  57. Ducloux D , Bresson-Vautrin C , Chalopin J . Use of pentoxiphylline in membranous nephropathy . Lancet . 2001;357:1672–1673
  58. Choi MJ , Eustace JA , Gimenez LF , et al.   Mycophenolate mofetil treatment for primary glomerular diseases . Kidney Int . 2002;61:1068–1114

 This review is excerpted from a Cochrane Review that will be published in The Cochrane Library 2004, Issue 4 (http://www.update-software.com/cochrane). Cochrane Reviews are regularly updated as new evidence emerges in response to comments and criticisms, and The Cochrane Library should be consulted for the most recent version of the Review.

PII: S0272-6386(04)00809-1

doi: 10.1053/j.ajkd.2004.05.020

American Journal of Kidney Diseases
Volume 44, Issue 3 , Pages 385-401 , September 2004

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