American Journal of Kidney Diseases
Volume 46, Issue 6 , Pages 1129-1139 , December 2005

Pharmacology

  • Mark A. Perazella, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Mark A. Perazella, MD, Section of Nephrology, FMP 110, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520-8029.
    • ,
  • Chirag Parikh, MD, PhD

Received 13 May 2005 ,Accepted 13 July 2005.

  • Image Result

    Schematic model of renal proximal tubule with organic anion and cation transporters. Both endogenous substances and drugs are secreted and reabsorbed by these transporters. Patients with renal failure

    Schematic model of renal proximal tubule with organic anion and cation transporters. Both endogenous substances and drugs are secreted and reabsorbed by these transporters. Patients with renal failure may develop toxicity due to competition for these pathways of secretion due to endogenous substances and medications that compete for these transporters (see text). Abbreviations: OA, organic anion; OC, organic cation; OAT, OA transporter; OCT, OC transporter; PEPT 1/2, peptide transporters 1 and 2; MRP2, multidrug-resistant transporter.

 Originally published online as doi:10.1053/j.ajkd.2005.07.051 on October 26, 2005.

PII: S0272-6386(05)01240-0

doi: 10.1053/j.ajkd.2005.07.051

American Journal of Kidney Diseases
Volume 46, Issue 6 , Pages 1129-1139 , December 2005

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