American Journal of Kidney Diseases
Volume 46, Issue 6 , Pages 1124-1128 , December 2005

Thrombotic Microangiopathy in Marginal Kidneys After Sirolimus Use

Received 11 May 2005 ,Accepted 30 August 2005.

References 

  1. Pisani F , Buonomo O , Iaria G , et al.   Sirolimus in kidney transplantation from marginal donors . Transplant Proc . 2004;36:495–496
  2. Schwimmer J , Nadasdy TA , Spitalnyk PF , Kaplan KL , Zand MS . De novo thrombotic microangiopathy in renal transplant recipients (A comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy) . Am J Kidney Dis . 2003;41:471–479
  3. Franco A  HUS-Sirolimus Spanish Study Group . De novo hemolytic uremic syndrome/thrombotic microangiopathy in renal transplanted patients receiving calcineurine inhibitors. The role of sirolimus . Transplant Proc . 2003;35:1764–1766
  4. Davin JC , Gruppen M , Bouts AH , Groothoff JW , Van Amstel SP , Surachno J . Relapse of atypical hemolytic uremic syndrome after kidney transplantation (Role of ATG and failure of mycophenolate mofetil as rescue therapy) . Nephrol Dial Transplant . 1999;14:984–987
  5. Langer RM , Van Buren CT , Katz SM , Kahan BD . De novo hemolytic uremic syndrome after kidney transplantation in patients treated with cyclosporine A-sirolimus combination . Transplantation . 2002;73:756–760
  6. Saikali JA , Truong LD , Suki WN . Sirolimus may promote thrombotic microangiopathy . Am J Transplant . 2003;3:229–230
  7. Reynolds JC , Agodoa LY , Yuan CM , Abbott KC . Thrombotic microangiopathy after renal transplantation in the United States . Am J Kidney Dis . 2003;42:1058–1068
  8. Barone GW , Gurley BJ , Abul-Ezz SR , Gökden N . Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient . Am J Kidney Dis . 2003;42:202–206
  9. Crew RJ , Radhakrishnan J , Cohen DJ , Stern L , Goldstein M , Hardy M . De novo thrombotic microangiopathy following treatment with sirolimus (Report of two cases) . Nephrol Dial Transplant . 2005;20:203–209
  10. Marti HP , Frey FJ . Nephrotoxicity of rapamycin (An emerging problem in clinical medicine) . Nephrol Dial Transplant . 2005;20:13–15
  11. Morelon E , Stern M , Israël-Biet D , et al.   Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients . Transplantation . 2001;72:787–790
  12. Moses JW , Leon MB , Popma JJ , et al.   Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery . N Engl J Med . 2003;349:1315–1323

 Originally published online as doi:10.1053/j.ajkd.2005.08.037 on October 31, 2005.

PII: S0272-6386(05)01445-9

doi: 10.1053/j.ajkd.2005.08.037

American Journal of Kidney Diseases
Volume 46, Issue 6 , Pages 1124-1128 , December 2005

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