American Journal of Kidney Diseases
Volume 47, Issue 3 , Pages 385-395, March 2006

The Second United Kingdom Heart and Renal Protection (UK-HARP-II) Study: A Randomized Controlled Study of the Biochemical Safety and Efficacy of Adding Ezetimibe to Simvastatin as Initial Therapy Among Patients With CKD

This work was presented in abstract form at the Scientific Sessions of the American Heart Association, Orlando, FL, November 10, 2003.

  • Martin Landray, MRCP, PhD

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • Corresponding Author InformationAddress reprint requests to Martin Landray, MRCP, PhD, Renal Studies Group, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Richard Doll Bldg, University of Oxford, Old Road Campus, Roosevelt Dr, Oxford, OX3 7LF, UK
    • ,
  • Colin Baigent, BM, BCh

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Craig Leaper, PhD

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Dwomoa Adu, MD (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Paul Altmann, MBBS, MD (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Jane Armitage, MRCP, MFPH

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Simon Ball, MBBS, MRCP

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Alex Baxter, MA

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Lisa Blackwell, BSc

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Hugh S. Cairns, MD

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Sue Carr, MD (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Rory Collins (FMedSci)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Karen Kourellias

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Mary Rogerson, MD

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • John E. Scoble, MD

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Charles R.V. Tomson, DM (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • Graham Warwick, MD (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK
    • ,
  • David C. Wheeler, MD (FRCP)

      Affiliations

    • Clinical Trial Service Unit, University of Oxford; Churchill Hospital, Oxford, UK
    • Queen Elizabeth Hospital, Birmingham, UK
    • Kings College Hospital, London, UK
    • Guy’s and St Thomas’s Hospital, London, UK
    • Royal Free and University College Medical School, London, UK
    • Leicester General Hospital, Leicester, UK
    • Southampton General Hospital, Southampton, UK
    • Southmead Hospital, Bristol, UK

Received 22 July 2005; accepted 14 November 2005. published online 20 January 2006.

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 Support: This study was funded by an unrestricted grant to Oxford University from Merck & Co., Inc. The Clinical Trial Service Unit has a staff policy of not accepting honoraria or other payments from the pharmaceutical industry, except for the reimbursement of costs to participate in scientific meetings. Potential conflicts of interest: None.

 Originally published online as doi:10.1053/j.ajkd.2005.11.018 on January 23, 2006.

PII: S0272-6386(05)01821-4

doi:10.1053/j.ajkd.2005.11.018

American Journal of Kidney Diseases
Volume 47, Issue 3 , Pages 385-395, March 2006

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