American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 394-400 , March 2007

A Genome-Wide Search for Linkage to Renal Function Phenotypes in West Africans With Type 2 Diabetes

  • Guanjie Chen, MD

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • Corresponding Author InformationAddress reprint requests to Guanjie Chen, MD, National Human Genome Center, Howard University, Genetic Epidemiology Unit, College of Medicine, 2216 6th St NW, Washington, DC 20059.
    • ,
  • Adebowale A. Adeyemo, MD

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • University of Ibadan, College of Medicine, Ibadan
    • ,
  • Jie Zhou, BS

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • ,
  • Yuanxiu Chen, MD, PhD

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • ,
  • Ayo Doumatey, MS

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • ,
  • Kerrie Lashley, BS

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • ,
  • Hanxia Huang, MD

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC
    • ,
  • Albert Amoah, MD, PhD

      Affiliations

    • Department of Medicine, University of Ghana Medical School, Accra
    • ,
  • Kofi Agyenim-Boateng, MD

      Affiliations

    • Department of Medicine, University of Science and Technology, Kumasi, Ghana
    • ,
  • Benjamin A. Eghan Jr, MD

      Affiliations

    • Department of Medicine, University of Science and Technology, Kumasi, Ghana
    • ,
  • Godfrey Okafor, MD

      Affiliations

    • Department of Medicine, University of Nigeria Teaching Hospital, Enugu
    • ,
  • Joseph Acheampong, MD

      Affiliations

    • Department of Medicine, University of Science and Technology, Kumasi, Ghana
    • ,
  • Johnnie Oli, MD

      Affiliations

    • Department of Medicine, University of Nigeria Teaching Hospital, Enugu
    • ,
  • Olufemi Fasanmade, MD

      Affiliations

    • Endocrine and Metabolic Unit, University of Lagos, College of Medicine, Lagos, Nigeria.
    • ,
  • Thomas Johnson, MD

      Affiliations

    • Endocrine and Metabolic Unit, University of Lagos, College of Medicine, Lagos, Nigeria.
    • ,
  • Charles Rotimi, PhD

      Affiliations

    • National Human Genome Center at Howard University, College of Medicine, Washington, DC

Received 16 March 2006 ,Accepted 11 December 2006.

References 

  1. US Renal Data System. USRDS 1999 Annual Data Report. Bethesda MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 1999;
  2. US Renal Data System. USRDS 2002 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2002;
  3. Caramori ML, Fioretto P, Mauer M. Low glomerular filtration rate in normoalbuminuruc type 1 diabetic patients. Diabetes. 2003;52:1036–1040
  4. Rodrigo E, de Francisco AL, Escallada R, et al. Measurement of renal function in pre-ESRD patients. Kidney Int Suppl. 2002;80:S11–S17
  5. Placha G, Canani LH, Warram JH, Krolewski AS. Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes. Adv Chronic Kidney Dis. 2005;12:155–169
  6. Bowden DW, Colicigno CJ, Langefeld CD, et al. A genome scan for diabetic nephropathy in African Americans. Kidney Int. 2004;66:1517–1526
  7. DeWan AT, Arnett DK, Atwood LD, et al. A genome scan for renal function among hypertension: The HyperGen Study. Am J Hum Genet. 2001;68:136–144
  8. DeWan AT, Arnett DK, Miller MB, et al. Refined mapping of suggestive linkage to function in African Americans: The HyperGEN Study. Am J Hum Genet. 2002;71:204–205
  9. Freedman IB, Stephanie RB, Rich SS, et al. HyperGen Investigators A genome wide scan for urinary albumin excretion in hypertensive families. Hypertension. 2003;42:291–296
  10. Fox CS, Yang Q, Guo CY, et al. Genome wide linkage analysis to urinary microalbuminuria in a community-based sample: The Framingham Heart Study. Kidney Int. 2004;67:70–74
  11. Rotimi C, Dunston GM, Berg K, et al. In search of susceptibility genes for type 2 diabetes in West Africa: The design and results of the first phase of the AADM Study. Ann Epidemiol. 2001;11:51–58
  12. Rotimi C, Chen G, Adeyemo A, et al. A genome-wide search for type 2 diabetes susceptibility genes in West Africans. Diabetes. 2004;53:1–4
  13. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  14. Hutson P, Tutsch K, Pomplun M, et al: Carboplatin dosing in obese patients. 14th ASCO Annual Meeting, May 2000, New Orleans, LA. Proc Am Soc Clin Oncol 19:2000 (abstr 725)
  15. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D Modification of Diet in Renal Disease Study Group. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Ann Intern Med. 1999;130:461–470
  16. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(suppl 2):S1–S249
  17. Case Western Reserve University. S.A.G.E. Statistical Analysis for Genetic Epidemiology, Release 4.0. Cleveland, OH: Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University; 2000;
  18. O’Connell JR, Weeks DE. PedCheck: A program for identifying genotype incompatibilities in linkage analysis. Am J Hum Genet. 1998;63:259–266
  19. Weir BZ. Genetic Data Analysis II: Methods for Discrete Population Genetic Data. Sunderland, MA: Sinauer; 1996;
  20. Fernandez JR, Etzel C, Beasley TM, Shete S, Amos CI, Allison DB. Improving the power of sib pair quantitative trait loci detection by phenotype winsorization. Hum Hered. 2002;53:59–67
  21. Allison BD, Neale CM, Zannolli R, Schork N, Amos IC, Blangero J. Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trail loci-mapping procedure. Am J Hum Genet. 1999;65:531–544
  22. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995;57:439–454
  23. Ott J. In: Methods of linkage analysis, in Analysis of Human Genetic Linkage: Revised Edition. Baltimore, MD: John Hopkins University; 1991;p. 65–68
  24. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin—Rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet. 2002;30:97–101
  25. Cohn DH, Shohat T, Yahav M, et al. A locus for an autosomal dominant form of progressive renal failure and hypertension at chromosome 1q21. Am J Hum Genet. 2000;67:647–651
  26. Hunt SC, Hasstedt SJ, Coon H, et al. Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat. Kidney Int. 2002;62:1143–1148
  27. Cheng G, Gao Z, Xu X, Van Meir EG, Lambeth JD. Homologs of gp91phox: Cloning and tissue expression of Nox3, Nox4, and Nox5. Gene. 2001;269:131–140
  28. Onozato LM, Tojo A. Role of NADPH oxidase in hypertension and diabetic nephropathy. Curr Hypertens Rev. 2005;1:15–20
  29. Jaimes E, Tian RX, Raij L. Nicotine: The link between cigarette smoking and the progression of renal injury?. Am J Physiol Heart Circ Physiol. 2006;
  30. Rave K, Nosek L, Posner J, Heise T, Roggen K, Van Hoogdalem EJ. Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes—Results of a hyperglycaemic glucose clamp study. Nephrol Dial Transplant. 2006;21:2166–2171
  31. Silander K, Scott JL, Valle TT, et al. A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes. 2004;53:821–829
  32. Dewan AT, Eckfeldt J, Rao DC, et al: A genome wide scan for creatinine clearance among hypertensive siblings: The HyperGEN Network of the NHLBI Family Blood Program, 49th America Society Human Genetics Annual Meeting, October 1999, San Francisco, CA, Program no. 1373
  33. Chabrashvili T, Tojo A, Onozato ML, et al. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension. 2002;39:269–274

 Originally published online as doi:10.1053/j.ajkd.2006.12.011 on February 1, 2007.

 Support: Support for the Africa America Diabetes Mellitus (AADM) study is provided by NIH grant no. 3T37TW00041-03S2 from the Office of Research on Minority Health. This project also is supported in part by the National Center for Research Resources (NCRR), National Human Genome Research Institute (NHGRI), and by the NIDDK grant DK-54001. Genotyping services were provided by the Center for Inherited Disease Research (http://www.cidr.jhmi.edu). The Center for Inherited Disease Research is fully funded through a federal contract from the NIH to Johns Hopkins University, Contract No. N01-HG-65403. Potential conflicts of interest: None.

PII: S0272-6386(06)01912-3

doi: 10.1053/j.ajkd.2006.12.011

American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 394-400 , March 2007

Article Tools

* Image Usage & Resolution