American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 401-408 , March 2007

Aspirin Treatment Is Associated With a Significantly Decreased Risk of Staphylococcus aureus Bacteremia in Hemodialysis Patients With Tunneled Catheters

  • Martin Sedlacek, MD

      Affiliations

    • Dartmouth-Hitchcock Medical Center, Lebanon, NH
    • Dartmouth School of Medicine, Lebanon, NH
    • Corresponding Author InformationAddress reprint requests to Martin Sedlacek, MD, Division of Nephrology, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756-0001.
    • ,
  • John M. Gemery, MD

      Affiliations

    • Dartmouth-Hitchcock Medical Center, Lebanon, NH
    • Dartmouth School of Medicine, Lebanon, NH
    • ,
  • Ambrose L. Cheung, MD

      Affiliations

    • Dartmouth School of Medicine, Lebanon, NH
    • ,
  • Arnold S. Bayer, MD

      Affiliations

    • UCLA School of Medicine, Torrance, CA
    • Harbor-UCLA Medical Center, Torrance, CA.
    • ,
  • Brian D. Remillard, MD

      Affiliations

    • Dartmouth-Hitchcock Medical Center, Lebanon, NH
    • Dartmouth School of Medicine, Lebanon, NH

Received 21 June 2006 ,Accepted 11 December 2006.

References 

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  2. Kessler M, Hoen B, Mayeux D, Hestin D, Fontenaille C. Bacteremia in patients on chronic hemodialysis: A multicenter prospective survey. Nephron. 1992;64:95–100
  3. Rayner HC, Besarab A, Brown W, Disney A, Saito A, Pisoni RL. Vascular access results from the Dialysis Outcomes and Practice Patterns Study (DOPPS): Performance against Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines. Am J Kidney Dis. 2004;44(suppl 2):S22–S26
  4. Leeb M. A shot in the arm. Nature. 2004;431:892–893
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  13. Schunemann S, Werner GS, Schulz R, Bitsch A, Prange HW, Kreuzer H. Embolische Komplikationen bei bakterieller Endokarditis. Z Kardiol. 1997;86:1017–1025
  14. Taha TH, Durrant SS, Mazeika PK, Nihoyannopoulos P, Oakley CM. Aspirin to prevent growth of vegetations and cerebral emboli in infective endocarditis. J Intern Med. 1992;231:543–546
  15. Chan K-L, Dumesnil JG, Cujec B, et al. A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis. J Am Coll Cardiol. 2003;42:775–780
  16. Patrono C, Coller B, FitzGerald GA, Hirsh J, Roth G. Platelet-active drugs: The relationships among dose, effectiveness, and side effects (The Seventh ACCP Conference on Antithrombotic and Thromboltic Therapy). Chest. 2004;126(suppl 3):S234–S264
  17. Kluytmans JAJW, Wertheim HFL. Nasal carriage of Staphylococcus aureus and prevention of nosocomial infections. Infection. 2004;33:3–8
  18. Little MA, O’Riordan A, Lucey B, et al. A prospective study of complications associated with cuffed, tunneled haemodialysis catheters. Nephrol Dial Transplant. 2001;16:2194–2200
  19. Breen JD, Karchmer AW. Staphylococcus aureus infections in diabetic patients. Infect Dis Clin North Am. 1995;9:11–24
  20. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients. Am J Kidney Dis. 2005;45(suppl 3):S1–S153
  21. Kupferwasser LI, Yeaman MR, Shapiro SM, et al. Acetylsalicylic acid reduces vegetation bacterial density, hematogenous bacterial dissemination, and frequency of embolic events in experimental staphylococcus aureus endocarditis through antiplatelet and antibacterial effects. Circulation. 1999;99:2791–2797

 Originally published online as doi:10.1053/j.ajkd.2006.12.014 on February 1, 2007.

 Support: A.S.B. is supported by NIH grant AI-39108, and A.L.C. is supported by NIH grant AI-37142. Potential conflicts of interest: None.

PII: S0272-6386(06)01916-0

doi: 10.1053/j.ajkd.2006.12.014

American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 401-408 , March 2007

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