American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 356-364 , March 2007

Lack of Synergistic Effects of Metabolic Syndrome and Plasma Fibrinogen on Coronary Events and Mortality in Moderate CKD

  • Nirupama Ramkumar, MD

      Affiliations

    • Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT
  • ,
  • Maureen A. Murtaugh, PhD, RD

      Affiliations

    • Department of Family Practice and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT
  • ,
  • Alfred K. Cheung, MD

      Affiliations

    • Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT
    • Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT.
  • ,
  • Srinivasan Beddhu, MD

      Affiliations

    • Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, UT
    • Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT.
    • Corresponding Author InformationAddress reprint requests to Srinivasan Beddhu, MD, Associate Professor of Medicine, 85 North Medical Dr East, Rm 201, Salt Lake City, UT 84112.

Received 21 August 2006 ,Accepted 12 December 2006.

References 

  1. Ridker PM, Buring JE, Cook NR, Rifai N. C-Reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107:391–397
  2. Ridker PM, Rifai N, Pfeffer MA, et al. Cholesterol and Recurrent Events (CARE) Investigators Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Circulation. 1998;98:839–844
  3. Festa A, D’Agostino R, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102:42–47
  4. Festa A, Hanley AJ, Tracy RP, D’Agostino R, Haffner SM. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation. 2003;108:1822–1830
  5. Sattar N, Gaw A, Scherbakova O, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation. 2003;108:414–419
  6. Beddhu S, Kimmel PL, Ramkumar N, Cheung AK. Associations of metabolic syndrome with inflammation in CKD: Results from the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis. 2005;46:577–586
  7. Coresh J, Astor BC, McQuillan G, et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am J Kidney Dis. 2002;39:920–929
  8. Siedel J, Hagele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem. 1983;29:1075–1080
  9. Nagele U, Hagele EO, Sauer G, et al. Reagent for the enzymatic determination of serum total triglycerides with improved lipolytic efficiency. J Clin Chem Clin Biochem. 1984;22:165–174
  10. Warnick GR, Benderson JM, Albers JJ. Quantitation of high-density lipoprotein subclasses after separation by dextran sulfate and Mg2+ precipitation. Clin Chem. 1982;28:1574
  11. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  12. Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957;17:237–246
  13. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  14. National Heart, Lung, and Blood Institute. Atherosclerosis Risk in Communities (ARIC) Study (Operations Manual). Chapel Hill, NC: ARIC Coordinating Center, School of Public Health, University of North Carolina; 1987;
  15. Foley RN, Murray AM, Li S, et al. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999. J Am Soc Nephrol. 2005;16:489–495
  16. Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horwich TB. Survival advantages of obesity in dialysis patients. Am J Clin Nutr. 2005;81:543–554
  17. Muntner P, He J, Astor BC, Folsom AR, Coresh J. Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: Results from the Atherosclerosis Risk in Communities Study. J Am Soc Nephrol. 2005;16:529–538
  18. Laaksonen DE, Niskanen L, Nyyssonen K, et al. C-Reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. Diabetologia. 2004;47:1403–1410
  19. Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002;105:804–809
  20. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115:1111–1119
  21. Bouloumie A, Marumo T, Lafontan M, Busse R. Leptin induces oxidative stress in human endothelial cells. FASEB J. 1999;13:1231–1238
  22. Quehenberger P, Exner M, Sunder-Plassmann R, et al. Leptin induces endothelin-1 in endothelial cells in vitro. Circ Res. 2002;90:711–718
  23. Ouchi N, Kihara S, Funahashi T, et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation. 2003;107:671–674
  24. Stephens JM, Pekala PH. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem. 1991;266:21839–21845
  25. Bastard JP, Jardel C, Delattre J, Hainque B, Bruckert E, Oberlin F. Evidence for a link between adipose tissue interleukin-6 content and serum C-reactive protein concentrations in obese subjects. Circulation. 1999;99:2221–2222
  26. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996;271:665–668
  27. Nakajima J, Mogi M, Kage T, Chino T, Harada M. Hypertriglyceridemia associated with tumor necrosis factor-alpha in hamster cheek-pouch carcinogenesis. J Dent Res. 1995;74:1558–1563
  28. Tham DM, Martin-McNulty B, Wang YX, et al. Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs. Physiol Genomics. 2002;11:21–30
  29. Verma S, Li SH, Wang CH, et al. Resistin promotes endothelial cell activation: Further evidence of adipokine-endothelial interaction. Circulation. 2003;108:736–740
  30. von Eynatten M, Schneider JG, Humpert PM, et al. Decreased plasma lipoprotein lipase in hypoadiponectinemia: An association independent of systemic inflammation and insulin resistance. Diabetes Care. 2004;27:2925–2929
  31. Bhagat K, Vallance P. Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation. 1997;96:3042–3047
  32. Schneider JG, von Eynatten M, Schiekofer S, Nawroth PP, Dugi KA. Low plasma adiponectin levels are associated with increased hepatic lipase activity in vivo. Diabetes Care. 2005;28:2181–2186
  33. Whitehead JP, Richards AA, Hickman IJ, Macdonald GA, Prins JB. Adiponectin—A key adipokine in the metabolic syndrome. Diabetes Obes Metab. 2006;8:264–280
  34. Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731–737
  35. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941–946
  36. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia. 2003;46:459–469
  37. Stern MP. Diabetes and cardiovascular disease—The “common soil” hypothesis. Diabetes. 1995;44:369–374

 Originally published online as doi:10.1053/j.ajkd.2006.12.015 on January 31, 2007.Support: This study was supported by grants from the National Kidney Foundation of Utah and Idaho and the Dialysis Research Foundation. Potential conflicts of interest: None.

PII: S0272-6386(06)01917-2

doi: 10.1053/j.ajkd.2006.12.015

American Journal of Kidney Diseases
Volume 49, Issue 3 , Pages 356-364 , March 2007