American Journal of Kidney Diseases
Volume 49, Issue 6 , Pages 862-864 , June 2007

Nephrolithiasis With Hypomagnesemia: What Is the Cause?

  • Hassane Izzedine, MD, PhD

      Affiliations

    • Department of Nephrology, Pitié-Salpêtrière Hospital, Paris, France
    • Corresponding Author InformationAddress correspondence to Hassane Izzedine, MD, PhD, Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l’Hôpital, Assistance Publique-Hopitaux de Paris, Pierre et Marie Curie University, 75013 Paris-France.
    • ,
  • Hadjira Benalia, MD

      Affiliations

    • Department of Renal Transplantation, Pitié-Salpêtrière Hospital, Paris, France
    • ,
  • Nadia Arzouk, MD

      Affiliations

    • Department of Renal Transplantation, Pitié-Salpêtrière Hospital, Paris, France
    • ,
  • Xavier Jeunemaitre, MD, PhD

      Affiliations

    • Department of Genetics, Georges Pompidou Hospital, Paris, France.
    • ,
  • Sabria Hacini, MD

      Affiliations

    • Department of Nephrology, Pitié-Salpêtrière Hospital, Paris, France
    • ,
  • Edward Bourry, MD

      Affiliations

    • Department of Nephrology, Pitié-Salpêtrière Hospital, Paris, France
    • ,
  • Benoit Barrou, MD, PhD

      Affiliations

    • Department of Renal Transplantation, Pitié-Salpêtrière Hospital, Paris, France

Received 23 December 2006 ,Accepted 19 February 2007.

References 

  1. Geven WB, Monnens LA, Willems HL, Buijs WC, ter Haar BG. Renal magnesium wasting in two families with autosomal dominant inheritance. Kidney Int. 1987;31:1140–1144
  2. Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians. 1966;79:221–235
  3. Weber S, Schneider L, Peters M, et al. Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2001;12:1872–1881
  4. Michelis MF, Drash AL, Linarelli LG, De Rubertis FR, Davis BB. Decreased bicarbonate threshold and renal magnesium wasting in a sibship with distal renal tubular acidosis: Evaluation of the pathophysiological role of parathyroid hormone. Metabolism. 1972;21:905–920
  5. Simon DB, Lu Y, Choate KA, et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 1999;285:103–106
  6. Romani A, Scarpa A. Regulation of cell magnesium. Arch Biochem Biophys. 1992;298:1–12
  7. de Rouffignac C, Quamme G. Renal magnesium handling and its hormonal control. Physiol Rev. 1994;74:305–322
  8. Dai LJ, Ritchie G, Kerstan D, Kang HS, Cole DE, Quamme GA. Magnesium transport in the renal distal convoluted tubule. Physiol Rev. 2001;81:51–84
  9. Efrati E, Arsentiev-Rozenfeld J, Zelikovic I. The human paracellin-1 gene (hPCLN-1): Renal epithelial cell-specific expression and regulation. Am J Physiol Renal Physiol. 2005;288:F272–F283
  10. Tajima T, Nakae J, Fujieda K. Two heterozygous mutations of CLDN16 in a Japanese patient with FHHNC. Pediatr Nephrol. 2003;18:1280–1282
  11. Praga M, Vara J, Gonzalez-Parra E, et al. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Kidney Int. 1995;47:1419–1425
  12. Rodriguez-Soriano J, Vallo A, Garcia-Fuentes M. Hypomagnesaemia of hereditary renal origin. Pediatr Nephrol. 1987;1:465–472
  13. Köckerling A, Reinalter SC, Seyberth HW. Impaired response to furosemide in hyperprostaglandin E syndrome: Evidence for a tubular defect in the loop of Henle. J Pediatr. 1996;129:519–528
  14. Ulmann A, Hadj S, Lacour B, Bourdeau A, Bader C. Renal magnesium and phosphate wastage in a patient with hypercalciuria and nephrocalcinosis: Effect of oral phosphorus and magnesium supplements. Nephron. 1985;40:83–87
  15. Benigno V, Canonica CS, Bettinelli A, von Vigier RO, Truttmann AC, Bianchetti MG. Hypomagnesaemia-hypercalciurianephrocalcinosis: A report of nine cases and a review. Nephrol Dial Transplant. 2000;15:605–610

 Originally published online as doi:10.1053/j.ajkd.2007.02.265 on May 3, 2007.Support: None. Potential conflicts of interest: None.

PII: S0272-6386(07)00512-4

doi: 10.1053/j.ajkd.2007.02.265

American Journal of Kidney Diseases
Volume 49, Issue 6 , Pages 862-864 , June 2007

Article Tools