American Journal of Kidney Diseases
Volume 50, Issue 1 , Pages 78-89.e1 , July 2007

Baseline Characteristics of Participants in the African American Study of Kidney Disease and Hypertension (AASK) Clinical Trial and Cohort Study

Presented in part at the 2005 American Society of Nephrology conference, November 8-13, Philadelphia, PA.

  • Mohammed Sika, PhD

      Affiliations

    • Medicine, Vanderbilt, Nashville, TN
    • Corresponding Author InformationAddress correspondence to Mohammed Sika, PhD, Vanderbilt University Medical Center, Nephrology Clinical Trials Center, 1211 21st Ave South, 215 MAB, Nashville, TN 37232-1371.
    • ,
  • Julia Lewis, MD

      Affiliations

    • Medicine, Vanderbilt, Nashville, TN
    • ,
  • Janice Douglas, MD

      Affiliations

    • Hypertension, Case Western, Cleveland, OH
    • ,
  • Thomas Erlinger, MD, MPH

      Affiliations

    • Medicine, The University of Texas Medical Branch, Austin, TX
    • ,
  • Donna Dowie, MD

      Affiliations

    • Harlem Hospital, New York, NY
    • ,
  • Michael Lipkowitz, MD

      Affiliations

    • Mount Sinai, New York, NY
    • ,
  • James Lash, MD

      Affiliations

    • Preventive Medicine, University of Illinois, Chicago, IL
    • ,
  • Denise Cornish-Zirker, RN

      Affiliations

    • Internal Medicine, University of Michigan, Ann Arbor, MI
    • ,
  • Gail Peterson, MD

      Affiliations

    • Southwestern Medical Center, Dallas, TX
    • ,
  • Robert Toto, MD

      Affiliations

    • Southwestern Medical Center, Dallas, TX
    • ,
  • John Kusek, PhD

      Affiliations

    • National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda
    • ,
  • Lawrence Appel, MD

      Affiliations

    • Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Cynthia Kendrick, BS

      Affiliations

    • Biostatistics and Epidemiology, Cleveland Clinic, Cleveland, OH.
    • ,
  • Jennifer Gassman, PhD

      Affiliations

    • Biostatistics and Epidemiology, Cleveland Clinic, Cleveland, OH.
    • ,
  • AASK group

Received 21 November 2006 ,Accepted 6 March 2007.

References 

  1. US Renal Data System: USRDS 2006 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006;
  2. Gassman JJ, Greene T, Wright JT, et al. Design and statistical aspects of the African American Study of Kidney Disease and Hypertension. J Am Soc Nephrol. 2003;14:5154–5165
  3. Wright JT, Kusek TW, Toto RD, et al. Design and baseline characteristics of participation in the African American Study of Kidney Disease and Hypertension. Control Clin Trials. 1996;16:35–165
  4. Agodoa LY, Bakris GL, Beck G, et al. Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis. JAMA. 2001;285:2719–2728
  5. Wright JT, Bakris G, Greene T, et al. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease. JAMA. 2002;288:2421–2431
  6. Appel LJ, Middleton J, Miller ER, et al. The rationale and design of the AASK Cohort Study. J Am Soc Nephrol. 2003;14(suppl 2):S166–S172
  7. Chobanian AV, Bakris GL, Black GL, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–1252
  8. Lewis J, Agodoa L, Cheek D, et al. Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate. Am J Kidney Dis. 2001;388:744–753
  9. Lewis J, Greene T, Appel L, et al. A comparison of iothalamate-GFR and serum creatinine-based outcomes: Acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension. J Am Soc Nephrol. 2004;15:3175–3183
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  12. Appel LJ, Hebert PR, Cohen JD, et al. Baseline characteristics of participants in phase II of the trials of hypertensive prevention. Ann Epidemol. 1995;5:149–155
  13. Norris K, Greene T, Kopple J, et al. Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease. J Am Soc Nephrol. 2006;17:2928–2936
  14. Kafetz K. Renal impairment in the elderly: A review. J Royal Soc Med. 1983;76:398–401
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  16. Hemmelgarn BR, Zhang J, Manns BJ, et al. Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int. 2006;69:2155–2161
  17. Salahudeen AK. Halting progression of renal failure: Consideration beyond angiotensin II inhibition. Nephrol Dial Transplant. 2002;17:1871–1875
  18. Lewis EJ, Hunsiker LG, Bain RP, Rohde RD. The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. N Engl J Med. 1993;329:1456–1462
  19. Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345:851–860
  20. Brenner BM, Cooper ME, Zeeuw DD, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2006;345:861–869
  21. Parving HH, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001;345:870–878
  22. The GISEN Group. Randomized placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet. 1997;349:1857–1963
  23. Collins A, Kasiske B, Herzog C, et al. Excerpts from the United States Renal Data System 2004 Annual Report: Atlas of End-Stage Renal Disease in the United States. Am J Kidney Dis. 2005;45:v–vii

 Originally published online as doi: 10.1053/j.ajkd.2007.03.004 on May 29, 2007.

PII: S0272-6386(07)00559-8

doi: 10.1053/j.ajkd.2007.03.004

American Journal of Kidney Diseases
Volume 50, Issue 1 , Pages 78-89.e1 , July 2007

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