American Journal of Kidney Diseases
Volume 50, Issue 2 , Pages 270-278 , August 2007

Acute Variation in Cognitive Function in Hemodialysis Patients: A Cohort Study With Repeated Measures

  • Anne M. Murray, MD, MSc

      Affiliations

    • Department of Medicine, Geriatrics Division, Hennepin County Medical Center, Minneapolis, MN
    • Department of Medicine, University of Minnesota, Minneapolis, MN
    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • Corresponding Author InformationAddress correspondence to Anne M. Murray, MD, MSc, Chronic Disease Research Group, 914 South 8th St, Ste S-253, Minneapolis, MN 55404.
    • ,
  • Sarah L. Pederson, MA

      Affiliations

    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • ,
  • David E. Tupper, PhD

      Affiliations

    • Department of Neuropsychology, Hennepin County Medical Center, Minneapolis, MN
    • ,
  • Angela K. Hochhalter, PhD

      Affiliations

    • Department of Medicine, Scott and White Memorial Hospital, Temple, TX
    • ,
  • Wendy A. Miller, MD

      Affiliations

    • Department of Medicine, Hennepin County Medical Center, Minneapolis, MN
    • ,
  • Qi Li, MS

      Affiliations

    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • ,
  • David Zaun, MS

      Affiliations

    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • ,
  • Allan J. Collins, MD, FACP

      Affiliations

    • Department of Medicine, University of Minnesota, Minneapolis, MN
    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • Department of Medicine, Hennepin County Medical Center, Minneapolis, MN
    • ,
  • Robert Kane, MD

      Affiliations

    • School of Public Health, University of Minnesota, Minneapolis, MN.
    • ,
  • Robert N. Foley, MB

      Affiliations

    • Department of Medicine, University of Minnesota, Minneapolis, MN
    • Minneapolis Medical Research Foundation, Chronic Disease Research Group, Minneapolis, MN
    • Department of Medicine, Hennepin County Medical Center, Minneapolis, MN

Received 5 January 2007 ,Accepted 18 May 2007.

References 

  1. Nissenson AR, Marsh JT, Brown WS, Wolcott DL. Central nervous system function in dialysis patients: A practical approach. Semin Dial. 1991;4:115–123
  2. Williams MA, Sklar AH, Burright RG, Donovick PJ. Temporal effect of dialysis on cognitive functioning in patient with ESRD. Am J Kidney Dis. 2004;43:705–711
  3. Griva K, Newman SP, Harrison MJ, et al. Acute neuropsychological changes in hemodialysis and peritoneal dialysis patients. Health Psychol. 2003;22:570–578
  4. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State (A practical method for grading the cognitive state of patients for the clinician). J Psychiatr Res. 1975;12:189–198
  5. Benton AL, Hamsher K, Sivan AB. Multilingual Aphasia Examination. Iowa City, IA: AJA; 1994;
  6. Brandt J, Benedict RHB. Hopkins Verbal Learning Test—Revised (Professional Manual). Lutz, FL: Psychological Assessment Resources; 2001;
  7. D’Elia LF, Satz P, Uchiyama CL, White T. Color Trails Test (Professional Manual). Lutz, FL: Psychological Assessment Resources; 1996;
  8. Benedict RHB. Brief Visuospatial Memory Test—Revised (Professional Manual). Lutz, FL: Psychological Assessment Resources; 1997;
  9. Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res. 1982;17:37–49
  10. SAS Institute Inc. SAS/STAT User’s Guide, Version 9.1. Cary, NC: SAS Institute; 2006;
  11. US Renal Data System: USRDS 2005 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2005;
  12. Lewis EG, O’Neill WM, Dustman RE, Beck EC. Temporal effects of hemodialysis on measures of neural efficiency. Kidney Int. 1980;17:357–363
  13. Pliskin NH, Yurk HM, Ho LT, Umans JG. Neurocognitive function in chronic hemodialysis patients. Kidney Int. 1996;49:1435–1440
  14. English A, Savage RD, Britton PG, Ward MK, Kerr DN. Intellectual impairment in chronic renal failure. BMJ. 1978;1:888–890
  15. Ratner DP, Adams KM, Levin NW, Rourke BP. Effects of hemodialysis on the cognitive and sensory-motor functioning of the adult chronic hemodialysis patient. J Behav Med. 1983;6:291–311
  16. American Psychiatric Association. In: Diagnostic and Statistical Manual of Mental Disorders. (ed 4). Washington, DC: American Psychiatric Association; 1994;p. 124–133
  17. Murray AM, Levkoff SE, Wetle TT, et al. Acute delirium and functional decline in the hospitalized elderly patient. J Gerontol. 1993;48:M181–M186
  18. Kiely DK, Bergmann MA, Jones RN, Murphy KM, Orav EJ, Mancantonio ER. Characteristics associated with delirium persistence among newly admitted post-acute facility patients. J Gerontol A Biol Sci Med Sci. 2004;59:344–349
  19. Inouye SK, Viscoli CM, Horwitz RI, Hurst LD, Tinetti ME. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med. 1993;119:474–481
  20. Schor JD, Levkoff SE, Lipsitz LA, et al. Risk factors for delirium in hospitalized elderly. JAMA. 1992;267:827–831
  21. Arieff AJ. Dialysis dysequilibrium syndrome—Current concepts on pathogenesis and prevention. Kidney Int. 1994;45:629–635
  22. Gottlieb D, Mildworf B, Rubinger D, Melamed E. The regional cerebral blood flow in patients under chronic hemodialytic treatment. J Cereb Blood Flow Metab. 1987;7:659–661
  23. Postiglione A, Faccenda F, Gallotta G, Rubba P, Federico S. Changes in middle cerebral artery blood velocity in uremic patients after hemodialysis. Stroke. 1991;22:1508–1511
  24. Hata R, Matsumoto M, Handa N, Terakawa H, Sugitani Y, Kamada T. Effects of hemodialysis on cerebral circulation evaluated by transcranial Doppler ultrasonography. Stroke. 1994;25:408–412
  25. Ishida I, Hirakata H, Sugimori H, et al. Hemodialysis causes severe orthostatic reduction in cerebral blood flow velocity in diabetic patients. Am J Kidney Dis. 1999;34:1096–1104
  26. Murray AM, Tupper DE, Knopman DS, et al. Cognitive impairment in dialysis patients is common. Neurology. 2006;67:216–223
  27. Badzek L, Hines SC, Moss AH. Inadequate self-care knowledge among elderly hemodialysis patients: Assessing its prevalence and potential causes. ANNA J. 1998;25:293–300

PII: S0272-6386(07)00837-2

doi: 10.1053/j.ajkd.2007.05.010

American Journal of Kidney Diseases
Volume 50, Issue 2 , Pages 270-278 , August 2007

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