American Journal of Kidney Diseases
Volume 50, Issue 2 , Pages 279-288 , August 2007

Complex Compartmental Behavior of Small Water-Soluble Uremic Retention Solutes: Evaluation by Direct Measurements in Plasma and Erythrocytes

  • Sunny Eloot, PhD, MScBME, MScCivE

      Affiliations

    • Institute for Biomedical Technology, Ghent University, Ghent, Belgium
    • Corresponding Author InformationAddress correspondence to Sunny Eloot, PhD, MScBME, MScCivE, Institute for Biomedical Technology, Ghent University, De Pintelaan 185, Ghent, 9000 Belgium.
    • ,
  • An Torremans, PhD, MSc

      Affiliations

    • Laboratory of Neurochemistry and Behaviour, University of Antwerp, Antwerp, Belgium
    • ,
  • Rita De Smet, MScBME

      Affiliations

    • Nephrology Section, Ghent University Hospital, Ghent, Belgium.
    • ,
  • Bart Marescau, PhD, MSc

      Affiliations

    • Laboratory of Neurochemistry and Behaviour, University of Antwerp, Antwerp, Belgium
    • ,
  • Peter Paul De Deyn, PhD, MD

      Affiliations

    • Laboratory of Neurochemistry and Behaviour, University of Antwerp, Antwerp, Belgium
    • ,
  • Pascal Verdonck, PhD, MScBME, MScCivE

      Affiliations

    • Institute for Biomedical Technology, Ghent University, Ghent, Belgium
    • ,
  • Raymond Vanholder, PhD, MD

      Affiliations

    • Nephrology Section, Ghent University Hospital, Ghent, Belgium.

Received 22 December 2006 ,Accepted 18 May 2007.

References 

  1. Sargent JA. Shortfalls in the delivery of dialysis. Am J Kidney Dis. 1990;15:500–510
  2. Lowrie EG, Laird NM (eds): The National Cooperative Dialysis Study. Kidney Int Suppl 23:S1-S122, 1983
  3. Bloembergen WE, Stannard DC, Port FK, et al. Relationship of dose of hemodialysis and cause-specific mortality. Kidney Int. 1996;50:557–565
  4. Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347:2010–2019
  5. Paniagua R, Amato D, Vonesh E, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial. J Am Soc Nephrol. 2002;13:1307–1320
  6. D’Hooge R, De Deyn PP, Van de Vijver G, et al. Uraemic guanidino compounds inhibit gamma-aminobutyric acid-evoked whole cell currents in mouse spinal cord neurones. Neurosci Lett. 1999;265:83–86
  7. MacAllister RJ, Whitley GS, Vallance P. Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int. 1994;45:737–742
  8. Glorieux G, Dhondt A, Jacobs P, et al. In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection. Kidney Int. 2004;65:1–9
  9. Horowitz HI, Cohen BD, Martinez P, et al. Defective ADP-induced platelet factor 3 activation in uremia. Blood. 1967;30:331–340
  10. Giovannetti S, Cioni L, Balestri PL, et al. Evidence that guanidines and some related compounds cause haemolysis in chronic uraemia. Clin Sci. 1968;34:141–148
  11. Perna AF, Ingrosso D, Satta E, et al. Plasma protein aspartyl damage is increased in hemodialysis patients: Studies on causes and consequences. J Am Soc Nephrol. 2004;15:2747–2754
  12. Perna AF, Acanfora F, Lombardi C, et al. Increased plasma protein homocysteinylation in hemodialysis patients. Kidney Int. 2006;69:869–876
  13. Bostom AG, Shemin D, Lapane KL, et al. Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: A case control study. Atherosclerosis. 1995;114:93–103
  14. Vanholder R, Massy ZA, Argiles A, et al. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant. 2005;20:1048–1056
  15. Eloot S, Torremans A, De Smet R, et al. Kinetic behavior of urea is different from that of other water-soluble compounds: The case of the guanidino compounds. Kidney Int. 2005;67:1566–1575
  16. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: An analysis of error. J Am Soc Nephrol. 1993;4:1205–1213
  17. Ceriotti G. Ultramicrodetermination of plasma urea by reaction with diacetylmonoxime-antipyrine without deproteinization. Clin Chem. 1971;17:400–402
  18. Marescau B, Qureshi IA, De Deyn P, et al. Guanidino compounds in plasma, urine and cerebrospinal fluid of hyperargininemic patients during therapy. Clin Chim Acta. 1985;146:21–27
  19. Xiao R, Beck O, Hjemdahl P. On the accurate measurement of serotonin in whole blood. Scand J Clin Lab Invest. 1998;58:505–510
  20. Descombes E, Perriard F, Fellay G. Diffusion kinetics of urea, creatinine and uric acid in blood during hemodialysis (Clinical implications). Clin Nephrol. 1993;40:286–295
  21. Vander Velde C, Leonard EF. Theoretical assessment of the effect of flow maldistributions on the mass transfer efficiency of artificial organs. Med Biol Eng Comput. 1985;23:224–229
  22. De Deyn P, Marescau B, Lornoy W, et al. Guanidino compounds in uraemic dialysed patients. Clin Chim Acta. 1986;157:143–150
  23. De Deyn P, Marescau B, Lornoy W, et al. Serum guanidino compound levels and the influence of a single hemodialysis in uremic patients undergoing maintenance hemodialysis. Nephron. 1987;45:291–295
  24. Marescau B, Nagels G, Possemiers I, et al. Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism. 1997;46:1024–1031
  25. Barsotti G, Bevilacqua G, Morelli E, et al. Toxicity arising from guanidine compounds—Role of methylguanidine as a uremic toxin. Kidney Int Suppl. 1975;7:S299–S301
  26. Sargent JA, Gotch FA. Mathematical modeling of dialysis therapy. Kidney Int Suppl. 1980;10:S2–S10
  27. Gotch FA. Evolution of the single-pool urea kinetic model. Semin Dial. 2001;14:252–256
  28. Maasrani M, Jaffrin MY, Fischbach M, et al. Urea, creatinine and phosphate kinetic modeling during dialysis: Application to pediatric hemodialysis. Int J Artif Organs. 1995;18:122–129
  29. Koike J, Ujiie K, Owada A, et al. Quasi-steadiness approximation for the two-compartment solute kinetic model. Kidney Int. 1997;52:821–831
  30. Clark WR, Leypoldt JK, Henderson LW, et al. Quantifying the effect of changes in the hemodialysis prescription on effective solute removal with a mathematical model. J Am Soc Nephrol. 1999;10:601–609
  31. Ziolko M, Pietrzyk JA, Grabska-Chrzastowska J. Accuracy of hemodialysis modeling. Kidney Int. 2000;57:1152–1163
  32. Schneditz D, Daugirdas JT. Compartment effects in hemodialysis. Semin Dial. 2001;14:271–277
  33. Langsdorf LJ, Zydney AL. Effect of uremia on the membrane transport characteristics of red blood cells. Blood. 1993;81:820–827
  34. Shinzato T, Nakai S, Akiba T, et al. Survival in long-term haemodialysis patients: Results from the annual survey of the Japanese Society for Dialysis Therapy. Nephrol Dial Transplant. 1997;12:884–888

 Originally published online as doi:10.1053/j.ajkd.2007.05.009 on June 28, 2007.

PII: S0272-6386(07)00838-4

doi: 10.1053/j.ajkd.2007.05.009

American Journal of Kidney Diseases
Volume 50, Issue 2 , Pages 279-288 , August 2007

Article Tools

* Image Usage & Resolution