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American Journal of Kidney Diseases
Volume 51, Issue 1
, Pages 131-144
, January 2008
Cellular Senescence, Cardiovascular Risk, and CKD: A Review of Established and Hypothetical Interconnections
References
- . Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises (Part I: Aging arteries: A “set up” for vascular disease). Circulation. 2003;107:139–146
- . Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. (ed 7). Philadelphia, PA: Saunders; 2005;
- . Age-related changes in vascular responses: A review. Mech Ageing Dev. 1995;79:71–114
- Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci U S A. 1992;89:6998–7002
- . Aging and thrombosis. Semin Thromb Hemost. 2002;28:555–568
- . Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises (Part III: Cellular and molecular clues to heart and arterial aging). Circulation. 2003;107:490–497
- . Vascular cell senescence: Contribution to atherosclerosis. Circ Res. 2007;100:15–26
- Cardiovascular disease determinants in chronic renal failure: Clinical approach and treatment. Nephrol Dial Transplant. 2001;16:459–468
- . The pattern of inflammation and a potential new clinical meaning and usefulness of C-reactive protein in end-stage renal failure patients. Kidney Blood Press Res. 2005;28:55–61
- Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here?. Am J Kidney Dis. 1998;32:853–906
- . Epidemiology of cardiovascular disease in chronic renal failure. Am J Kidney Dis. 1998;32(suppl 3):S112–S119
- . The clinical epidemiology of cardiac disease in chronic renal failure. J Am Soc Nephrol. 1999;10:1606–1615
- . Telomere biology and cardiovascular disease. Circ Res. 2006;99:1167–1180
- . Premature senescence of endothelial cells: Methusaleh’s dilemma. Am J Physiol Heart Circ Physiol. 2006;290:1729–1739
- . When cells get stressed: An integrative view of cellular senescence. J Clin Invest. 2004;113:8–13
- . Historical claims and current interpretations of replicative aging. Nat Biotechnol. 2002;20:682–688
- . Cellular senescence: Mitotic clock or culture shock?. Cell. 2000;102:407–410
- . Cancer, aging and cellular senescence. In Vivo. 2000;14:183–188
- . Protein oxidation and degradation during cellular senescence of human BJ fibroblasts (I. Effects of proliferative senescence). FASEB J. 2000;14:2495–2502
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 2003;113:703–716
- . Putting the stress on senescence. Curr Opin Cell Biol. 2001;13:748–753
- . The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37:961–976
- . Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell. 2005;120:513–522
- . Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. Cell Sci. 2005;118:485–496
- . Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc Natl Acad Sci U S A. 2003;100:3251–3256
- . Cancer and aging: A model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol. 2002;34:1401–1414
- . DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 2004;23:2554–2563
- . Accumulation of oxidative DNA damage, 8-oxo-2′-deoxyguanoside, and change of repair systems during in vitro cellular aging of cultured human skin fibroblasts. Mutat Res. 2001;487:19–30
- . Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A. 1994;91:4130–4134
- . Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene. 1998;16:1113–1123
- . Limits to lifespan. Nat Cell Biol. 2002;4:E25–E27
- . P53 in health and disease. Nat Rev Mol Cell Biol. 2007;8:275–283
- . A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res. 1991;196:33–39
- Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J. 2003;22:4003–4013
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 2002;109:335–346
- A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995;92:9363–9367
- . Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res. 1995;217:336–345
- . Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem. 2003;278:11731–11734
- . Cellular senescence induced by p-53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts. J Cell Biochem. 2004;92:514–524
- . Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts. Exp Cell Res. 2004;299:36–48
- . Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J. 2000;347:543–551
- . Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis?. Cell Growth Differ. 1997;8:589–598
- Bcl-2 can promote p-53 dependent senescence versus apoptosis without affecting the G1/S transition. Biochem Biophys Res Commun. 2002;298:282–288
- . Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene. 2003;22:2805–2811
- . Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells. Mech Ageing Dev. 2002;123:613–625
- . Telomeres and telomerase: Their mechanism of action and the effects of altering their functions. FEBS Lett. 2005;579:859–862
- . Beginning to understand the end of the chromosome. Cell. 2004;116:273–279
- . Switching and signaling at the telomere. Cell. 2001;106:661–673
- . Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet. 2005;6:611–622
- . The terminal DNA structure of mammalian chromosomes. EMBO J. 1997;16:3705–3714
- . The DNA structures at the ends of eukaryotic chromosomes. Eur J Cancer. 1997;33:735–749
- . Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 1997;11:2801–2809
- Mammalian telomeres end in a large duplex loop. Cell. 1999;97:503–514
- . Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458–460
- . Senescence induced by altered telomere state, not telomere loss. Science. 2002;295:2446–2449
- . Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci U S A. 2003;100:527–531
- Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349–352
- . Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol. 1998;8:279–282
- . Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A. 1999;96:3723–3728
- Telomerase maintains telomere structure in normal human cells. Cell. 2003;114:241–253
- . Novel roles for telomerase in aging. Mech Aging Dev. 2006;127:579–583
- . Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction. Circulation. 2002;105:1541–1544
- . Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001;15:458–466
- . Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol. 2001;21:220–226
- . Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res. 2000;92:85–95
- . Endothelial aging. Cardiovasc Res. 2005;66:286–294
- . Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler Thromb Vasc Biol. 2007;27:266–274
- . Nitric oxide and endothelial cell aging. Eur J Clin Pharmacol. 2006;62:137–140
- . Nitric oxide—An endothelial cell survival factor. Cell Death Differ. 1999;6:964–968
- Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide. Circ Res. 2001;89:709–715
- . eNOS activity is reduced in senescent human endothelial cells (Preservation by hTERT immortalization). Circ Res. 2001;89:793–798
- . Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res. 2000;87:540–542
- Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes. Proc Natl Acad Sci USA. 2006;103:17018–17023
- . Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci. 2004;117:2417–2426
- . Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence. Arterioscler Thromb Vasc Biol. 2003;23:e1–e6
- Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med. 2000;192:1731–1744
- Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl l-arginine accelerates endothelial cell senescence. Arterioscler Thromb Vasc Biol. 2004;24:1816–1822
- . Microarray analysis of replicative senescence. Curr Biol. 1999;9:939–945
- . Telomerase induction in T cells: A cure for aging and disease?. Exp Gerontol. 2007;42:416–420
- . The role of CD8+ T-cell replicative senescence in human aging. Immunol Rev. 2005;205:147–157
- . Senescence stimulates U937-endothelial cell interactions. Exp Cell Res. 1993;208:270–274
- . The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature. 1993;362:801–809
- . Dampening inflammation. Nat Immunol. 2005;6:1179–1181
- . Resolution of inflammation: The beginning programs the end. Nat Immunol. 2005;6:1191–1197
- . Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol. 2005;25:174–179
- . The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med. 1999;5:335–339
- Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE 3-Leiden transgenic mice. Circ Res. 2001;88:780–786
- . Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling. Arterioscler Thromb Vasc Biol. 2003;23:1608–1614
- Activation of peroxisome proliferator-activated receptor γ suppresses telomerase activity in vascular smooth muscle cells. Circ Res. 2006;98:e50–e59
- . Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. FASEB J. 2004;18:418–420
- Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis (Effects of telomerase and oxidative stress). Circ Res. 2006;99:156–164
- Inductions of atherosclerotic plaque rupture in apolipoprotein E−/− mice after adenovirus-mediated transfer of p53. Circulation. 2002;105:2064–2070
- . The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability. Am J Nephrol. 2006;26:531–535
- . Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler Thromb Vasc Biol. 2007;27:15–26
- . Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol. 2006;35:681–688
- Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res. 2002;90:1290–1298
- Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation. 2006;114:953–960
- Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res. 2006;98:532–539
- Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol. 2000;20:3764–3771
- Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation. 2006;114:309–317
- Rise in insulin resistance is associated with escalated telomere attrition. Circulation. 2005;111:2171–2177
- . Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis. 2007;195:83–89
- . Telomere shortening occurs in Asian Indian type 2 diabetic patients. Diabet Med. 2005;22:1151–1156
- . Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care. 2006;29:283–289
- . Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab. 2006;91:635–640
- . Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension. 2000;36:195–200
- Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366:662–664
- Insulin resistance, oxidative stress, hypertension, and leukocyte length in men from the Framingham Heart Study. Aging Cell. 2006;5:325–330
- Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312–17315
- Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology. 2006;31:277–287
- . Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res. 2004;95:343–353
- . Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol. 2005;45:1441–1448
- . Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens. 2005;23:97–104
- . Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol. 2004;31:407–410
- C-Reactive protein attenuates endothelial progenitor cell survival, differentiation, and function (Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease). Circulation. 2004;109:2058–2067
- . C-Reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2006;26:2476–2482
- . Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens. 2005;23:1831–1837
- . Human telomere biology: Pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol. 2006;35:1424–1429
- . Telomere length and possible link to X chromosome. Lancet. 2004;363:507–510
- Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected, female sibling pairs. Am J Hum Genet. 2006;78:480–486
- Mapping of a major locus that determines telomere length in humans. Am J Hum Genet. 2005;76:147–151
- . The epigenetic regulation of mammalian telomeres. Nat Rev Genet. 2007;8:299–309
- . Epigenetic control of cellular senescence in disease: Opportunities for therapeutic intervention. Expert Rev Mol Med. 2007;9:1–26
- The effects of social status on biological ageing as measured by white cell telomere length. Aging Cell. 2006;5:361–367
- . Inflammatory mediators in the elderly. Exp Gerontol. 2004;39:687–699
- . Inflammation and atherosclerosis. Ann Rev Pathol Mech Dis. 2006;1:297–329
- . Inflammation in atherosclerosis and other conditions: A response to danger. Kidney Blood Press Res. 2005;28:211–217
- . Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004;84:1381–1478
- . Telomere shortening in atherosclerosis. Lancet. 2001;358:472–473
- . Association between telomere length blood and mortality in people aged 60 years or older. Lancet. 2003;361:393–395
- . White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23:842–846
- Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. Intern Med. 2003;42:150–153
- Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43:182–185
- Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study. Eur Heart J. 2007;28:172–176
- No association between telomere length and survival among the elderly and oldest old. Epidemiology. 2006;17:190–194
- Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol. 2007;165:14–21
- Telomere length, risk of coronary disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet. 2007;369:107–114
- HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res. 2003;92:1049–1055
- . Can telomere length predict cardiovascular risk?. Lancet. 2007;369:81–82
- Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. Circulation. 2004;110:3136–3142
- Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res. 2004;94:768–775
- Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res. 2004;94:377–384
- . Aspirin reduces endothelial cell senescence. Biochem Biophys Res Commun. 2005;334:1226–1232
- . Effect of l-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. Biochem Biophys Res Commun. 2006;245:1075–1082
- Raloxifene increases proliferation and upregulates telomerase activity in human umbilical vein endothelial cells. J Biol Chem. 2006;281:24270–24278
- Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis. Am J Kidney Dis. 2005;45:353–359
- Replicative senescence in patients with chronic kidney failure. Kidney Int Suppl. 2005;99:S11–S15
- . Telomere shortening and haemodialysis. Blood Purif. 2006;24:185–189
- Telomerase activity is decreased in peripheral blood mononuclear cells of hemodialysis patients. Am J Nephrol. 2006;26:91–96
- Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients. Nephrology (Carlton). 2006;11:506–509
- Grading evidence and recommendations for clinical practice guidelines in nephrology (A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)). Kidney Int. 2006;70:2058–2065
PII: S0272-6386(07)01364-9
doi: 10.1053/j.ajkd.2007.07.035
© 2007 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
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American Journal of Kidney Diseases
Volume 51, Issue 1
, Pages 131-144
, January 2008
