American Journal of Kidney Diseases
Volume 51, Issue 2 , Pages 233-241 , February 2008

A Meta-analysis of Hemodialysis Catheter Locking Solutions in the Prevention of Catheter-Related Infection

  • Yasmin Jaffer, MBChB

      Affiliations

    • Department of Renal Medicine, Derby City Hospital, Derby
    • ,
  • Nicholas M. Selby, MD

      Affiliations

    • Department of Renal Medicine, Derby City Hospital, Derby
    • ,
  • Maarten W. Taal, MD

      Affiliations

    • Department of Renal Medicine, Derby City Hospital, Derby
    • School of Graduate Entry Medicine and Healthcare, University of Nottingham, UK.
    • ,
  • Richard J. Fluck, MBBS

      Affiliations

    • Department of Renal Medicine, Derby City Hospital, Derby
    • ,
  • Christopher W. McIntyre, MD

      Affiliations

    • Department of Renal Medicine, Derby City Hospital, Derby
    • School of Graduate Entry Medicine and Healthcare, University of Nottingham, UK.
    • Corresponding Author InformationAddress correspondence to Christopher W. McIntyre, MD, Department of Renal Medicine, Derby City Hospital, Uttoxeter Rd, Derby, DE22 3NE, UK.

Received 26 June 2007 ,Accepted 25 October 2007.

References 

  1. UK Renal Registry. New Adult Patients Starting Renal Replacement Therapy in the UK in 2004 (UK Renal Registry Report). Bristol, UK: UK Renal Registry; 2005;chapter 3, pp 12-26
  2. Pisoni RL, Young EW, Dykstra DM, et al. Vascular access use in Europe and the United States: Results from the DOPPS. Kidney Int. 2002;61:305–316
  3. Allon M, Radeva M, Bailey J, et al. The spectrum of infection-related morbidity in hospitalized haemodialysis patients. Nephrol Dial Transplant. 2005;20:1180–1186
  4. US Renal Data System. USRDS 2004 Annual Data Report. Am J Kidney Dis. 2005;45(suppl 1):S8–S280
  5. Little MA, O’Riordan A, Lucey B, et al. A prospective study of complications associated with cuffed, tunnelled haemodialysis catheters. Nephrol Dial Transplant. 2001;16:2194–2200
  6. Ishani A, Collins AJ, Herzog CA, Foley RN. Septicemia, access and cardiovascular disease in dialysis patients: The USRDS Wave 2 study. Kidney Int. 2005;68:311–318
  7. Pastan S, Soucie JM, McClellan WM. Vascular access and increased risk of death among hemodialysis patients. Kidney Int. 2002;62:620–626
  8. Polkinghorne KR, McDonald SP, Atkins RC, Kerr PG. Vascular access and all-cause mortality: A propensity score analysis. J Am Soc Nephrol. 2004;15:477–486
  9. Taal MW, Fluck RJ, McIntyre CW. Preventing catheter related infections in haemodialysis patients. Curr Opin Nephrol Hypertens. 2006;15:599–602
  10. Mitchell D, Kessel D, Moss JG. The Organisation and Delivery of the Vascular Access Service for Maintenance Haemodialysis Patients: Report of a Joint Working Party. Vascular Access Report. In: The Renal Association, Clinical Service Committee; 2006;p. 11
  11. Nori US, Manoharan A, Yee J, Besarab A. Comparison of low-dose gentamicin with minocycline as catheter lock solutions in the prevention of catheter-related bacteremia. Am J Kidney Dis. 2006;48:596–605
  12. Schwab SJ, Beathard G. The hemodialysis catheter conundrum: Hate living with them, but can’t live without them. Kidney Int. 1999;56:1–17
  13. Dittmer ID, Sharp D, McNulty CA, Williams AJ, Banks RA. A prospective study of central venous hemodialysis catheter colonization and peripheral bacteremia. Clin Nephrol. 1999;51:34–39
  14. McIntyre CW, Hulme LJ, Taal M, Fluck RJ. Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney Int. 2004;66:801–805
  15. Tokars JI, Miller ER, Stein G. New national surveillance system for hemodialysis-associated infections: Initial results. Am J Infect Control. 2002;30:288–295
  16. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  17. Weijmer MC, van den Dorpel MA, Van de Ven PJ, et al. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients. J Am Soc Nephrol. 2005;16:2769–2777
  18. Dogra GK, Herson H, Hutchison B, et al. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: A randomized controlled study. J Am Soc Nephrol. 2002;13:2133–2139
  19. Betjes MG, van Agteren M. Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. Nephrol Dial Transplant. 2004;19:1546–1551
  20. Kim SH, Song KI, Chang JW, et al. Prevention of uncuffed hemodialysis catheter-related bacteremia using an antibiotic lock technique: A prospective, randomized clinical trial. Kidney Int. 2006;69:161–164
  21. Saxena AK, Panhotra BR, Sundaram DS, et al. Tunneled catheters’ outcome optimization among diabetics on dialysis through antibiotic-lock placement. Kidney Int. 2006;70:1629–1635
  22. US Food and Drug Administration. FDA Issues Warning on Tricitrasol Dialysis Catheter Anticoagulant. http://www.fda.gov/bbs/topics/ANSWERS/ANS01009.html2000;Accessed September 2007
  23. Taal MW, Fluck RJ, McIntyre CW. Preventing catheter related infections in haemodialysis patients. Curr Opin Nephrol Hypertens. 2006;15:599–602

 Originally published online as doi:10.1053/j.ajkd.2007.10.038 on January 4, 2008.

PII: S0272-6386(07)01489-8

doi: 10.1053/j.ajkd.2007.10.038

American Journal of Kidney Diseases
Volume 51, Issue 2 , Pages 233-241 , February 2008

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