American Journal of Kidney Diseases
Volume 51, Issue 3 , Pages 435-444 , March 2008

Albuminuria and Estimated GFR 5 Years After Escherichia coli O157 Hemolytic Uremic Syndrome: An Update

  • Amit X. Garg, MD, PhD

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
    • Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
    • Corresponding Author InformationAddress correspondence to Amit X. Garg, MD, PhD, Associate Professor, Medicine & Epidemiology, University of Western Ontario, Kidney Clinical Research Unit, Rm ELL-101, Westminster Tower, London Health Sciences Centre, 800 Commissioners Rd East, London, Ontario N6A 4G5, Canada.
  • ,
  • Marina Salvadori, MD

      Affiliations

    • Division of Pediatric Infectious Diseases, University of Western Ontario, London, Canada
  • ,
  • Justin M. Okell, BSc

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
  • ,
  • Heather R. Thiessen-Philbrook, MMath

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
  • ,
  • Rita S. Suri, MD

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
  • ,
  • Guido Filler, MD

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
  • ,
  • Louise Moist, MD, MSc

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
    • Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
  • ,
  • Douglas Matsell, MD

      Affiliations

    • Division of Pediatric Nephrology, University of British Columbia, Vancouver, Canada.
  • ,
  • William F. Clark, MD

      Affiliations

    • Division of Nephrology, University of Western Ontario, London, Canada
  • ,
  • Walkerton Health Study Investigators

Received 29 July 2007 ,Accepted 22 October 2007.

References 

  1. Martin DL, MacDonald KL, White KE, Soler JT, Osterholm MT. The epidemiology and clinical aspects of the hemolytic uremic syndrome in Minnesota. N Engl J Med. 1990;323:1161–1167
  2. Karmali MA, Petric M, Lim C, Fleming PC, Arbus GS, Lior H. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. 1985. J Infect Dis. 2004;189:556–563
  3. Garg AX, Suri RS, Barrowman N, et al. Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: A systematic review, meta-analysis, and meta-regression. JAMA. 2003;290:1360–1370
  4. Ogborn MR, Hamiwka L, Orrbine E, et al. Renal function in Inuit survivors of epidemic hemolytic-uremic syndrome. Pediatr Nephrol. 1998;12:485–488
  5. McLean MM, Jones CH, Sutherland DA. Haemolytic-uraemic syndrome (A report of an outbreak). Arch Dis Child. 1966;41:76–81
  6. Vermylen C, Bodart E, Ninane J, Moulin D, Cornu G. The haemolytic uraemic syndrome of childhood: Is living in Belgium a factor of good prognosis?. Acta Clin Belg. 1988;43:101–108
  7. Brichard B, Vermylen C, Heremans MT, Ninane J, Cornu G. Plasma infusion as treatment for 33 children with haemolytic uraemic syndrome: A good therapy?. Acta Clin Belg. 1993;48:156–163
  8. Miyazaki S. The etiology and clinical features of hemolytic uremic syndrome. Rinsho Ketsueki. 1994;35:341–345
  9. Riella MC, George CR, Hickman RO, et al. Renal microangiopathy of the hemolytic-uremic syndrome in childhood. Nephron. 1976;17:188–203
  10. Guyot C, Daniel MD, Roze JC, Renoult E, Dubigeon P, Buzelin F. Prognosis of hemolytic uremic syndrome in children (Importance of extrarenal involvement). Arch Fr Pediatr. 1986;43:253–258
  11. Rizzoni G, Claris-Appiani A, Edefonti A, et al. Plasma infusion for hemolytic-uremic syndrome in children: Results of a multicenter controlled trial. J Pediatr. 1988;112:284–290
  12. Brandt JR, Joseph MW, Fouser LS, et al. Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome. Pediatr Nephrol. 1998;12:222–225
  13. Sorrenti LY, Lewy PR. The hemolytic-uremic syndrome: Experience at a center in the Midwest. Am J Dis Child. 1978;132:59–62
  14. Campos A, Kim Y, Miller K, Mauer SM, Loken MK, Michael AF. Radionuclide studies of the kidney in children with hemolytic-uremic syndrome. Radiology. 1982;145:811–813
  15. Diekmann L. Treatment of the hemolytic-uremic syndrome with streptokinase and heparin (author’s translation). Klin Padiatr. 1980;192:430–435
  16. Loirat C, Beaufils F, Sonsino E, et al. Treatment of childhood hemolytic-uremic syndrome with urokinase (Cooperative controlled trial). Arch Fr Pediatr. 1984;41:15–19
  17. Henning PH, Tham EB, Martin AA, Beare TH, Jureidini KF. Haemolytic-uraemic syndrome outbreak caused by Escherichia coli O111:H: Clinical outcomes. Med J Aust. 1998;168:552–555
  18. Jones CA, Francis ME, Eberhardt MS, et al. Microalbuminuria in the US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2002;39:445–459
  19. Garg AX, Clark WF, Salvadori M, et al. Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination. Kidney Int. 2005;67:1476–1482
  20. Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58:259–263
  21. Garg AX, Macnab J, Clark W, et al. Long-term health sequelae following E. coli and Campylobacter contamination of municipal water (Population sampling and assessing non-participation biases). Can J Public Health. 2005;96:125–130
  22. Garg AX, Moist L, Matsell D, et al. Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water. CMAJ. 2005;173:261–268
  23. Garg AX, Marshall J, Salvadori M, et al. A gradient of acute gastroenteritis was characterized, to assess risk of long-term health sequelae after drinking bacterial-contaminated water. J Clin Epidemiol. 2006;59:421–428
  24. Auld H, MacIver D, Klaassen J. Heavy rainfall and waterborne disease outbreaks: The Walkerton example. J Toxicol Environ Health A. 2004;67:1879–1887
  25. Barratt TM, McLaine PN, Soothill JF. Albumin excretion as a measure of glomerular dysfunction in children. Arch Dis Child. 1970;45:496–501
  26. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2):S1–S266(suppl 1)
  27. Mueller PW, Caudill SP. Urinary albumin excretion in children: Factors related to elevated excretion in the United States population. Ren Fail. 1999;21:293–302
  28. Filler G, Foster J, Acker A, Lepage N, Akbari A, Ehrich JH. The Cockcroft-Gault formula should not be used in children. Kidney Int. 2005;67:2321–2324
  29. Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula?. Pediatr Nephrol. 2003;18:981–985
  30. Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C—A new marker of glomerular filtration rate in children independent of age and height. Pediatrics. 1998;101:875–881
  31. Roos JF, Doust J, Tett SE, Kirkpatrick CM. Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—A meta-analysis. Clin Biochem. 2007;40:383–391
  32. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis. Am J Kidney Dis. 2002;40:221–226
  33. Department of Health and Human Services. A SAS program for the CDC growth charts. www cdc gov/nccdphp/dnpa/growthcharts/resources/sas.htmAccessed December 17, 2007
  34. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–576
  35. Ribeiro MA. Levels of C-reactive protein in serum samples from healthy children and adults in Sao Paulo, Brazil. Braz J Med Biol Res. 1997;30:1055–1059
  36. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika. 1988;75:800–802
  37. Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: A paradigm shift in nephrology. Kidney Int. 1996;49:1774–1777
  38. de Jong M, Monnens L. Haemolytic-uraemic syndrome: A 10-year follow-up study of 73 patients. Nephrol Dial Transplant. 1988;3:379–382
  39. Gillor A, Bulla M, Roth B, et al. Plasmapheresis as a therapeutic measure in hemolytic-uremic syndrome in children. Klin Wochenschr. 1983;61:363–367
  40. Janssen F, Potvliege PR, Vainsel M, Vis HL. [Short- and long-term prognosis of the hemolytic-uremic syndrome]. Arch Fr Pediatr. 1974;31:59–69
  41. Monnens L, van Collenburg J, de Jong M, Zoethout H, van Wieringen P. Treatment of the hemolytic-uremic syndrome (Comparison of the results of heparin treatment with the results of streptokinase treatment). Helv Paediatr Acta. 1978;33:321–328
  42. Tonshoff B, Sammet A, Sanden I, Mehls O, Waldherr R, Scharer K. Outcome and prognostic determinants in the hemolytic uremic syndrome of children. Nephron. 1994;68:63–70
  43. Wende-Fischer R, Hoyer PF, Offner G, Brodehl J. Hamolytisch-uramisches Syndrom im Kindesalter [Haemolytic uraemic syndrome (Clinical features, treatment and prognostic indicators.]). Monatsschr Kinderheilkd. 1996;144:526–533
  44. Jones CA, McQuillan GM, Kusek JW, et al. Serum creatinine levels in the US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 1998;32:992–999

 A list of the Walkerton Health Study Investigators appears at the end of this article.

 Originally published online as doi:10.1053/j.ajkd.2007.10.042 on January 21, 2008.

PII: S0272-6386(07)01560-0

doi: 10.1053/j.ajkd.2007.10.042

American Journal of Kidney Diseases
Volume 51, Issue 3 , Pages 435-444 , March 2008