American Journal of Kidney Diseases
Volume 51, Issue 3 , Pages 445-454 , March 2008

A Comparison of Sevelamer and Calcium-Based Phosphate Binders on Mortality, Hospitalization, and Morbidity in Hemodialysis: A Secondary Analysis of the Dialysis Clinical Outcomes Revisited (DCOR) Randomized Trial Using Claims Data

  • Wendy L. St. Peter, PharmD

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
    • College of Pharmacy, University of Minnesota, Minneapolis, MN.
    • Corresponding Author InformationAddress correspondence to Wendy L. St. Peter, PharmD, Chronic Disease Research Group, Minneapolis Medical Research Foundation, 914 South 8th St, Ste S-206, Minneapolis, MN 55404.
    • ,
  • Jiannong Liu, PhD

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
    • ,
  • Eric Weinhandl, MS

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
    • ,
  • Qiao Fan, MS

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN

Received 11 July 2007 ,Accepted 6 December 2007.

References 

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  2. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol. 2004;15:2208–2218
  3. Slinin Y, Foley RN, Collins AJ. Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: The USRDS Waves 1, 3, and 4 Study. J Am Soc Nephrol. 2005;16:1788–1793
  4. Young EW, Albert JM, Satayathum S, et al. Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2005;67:1179–1187
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  7. London GM, Guérin AP, Marchais SJ, Métivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: Impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant. 2003;18:1731–1740
  8. Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension. 2001;38:938–942
  9. Chertow GM, Burke SK, Raggi P Treat to Goal Working Group. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int. 2002;62:245–252
  10. Block GA, Spiegel DM, Ehrlich J, et al. Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int. 2005;68:1815–1824
  11. Suki WA, Zabaneh R, Cangiano JL, et al. Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients. Kidney Int. 2007;72:1130–1137
  12. Therneau TM, Grambsch PM. Modeling Survival Data: Extending the Cox Model. In: New York, NY: Springer-Verlag; 2000;p. 169–229
  13. Block GA, Raggi P, Bellasi A, Kooienga L, Spiegel DM. Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney Int. 2007;71:438–441
  14. Thompson JR. Invited commentary: Re: “Multiple comparisons and related issues in the interpretation of epidemiologic data.”. Am J Epidemiol. 1998;147:801–806
  15. Cook DI, Gebski VJ, Keech AC. Subgroup analysis in clinical trials. Med J Aust. 2004;180:289–291
  16. Bland JM, Altman DG. Multiple significance tests: The Bonferroni method. BMJ. 1995;310:170

 Originally published online as doi:10.1053/j.ajkd.2008.01.004 on January 31, 2008.

PII: S0272-6386(07)01590-9

doi: 10.1053/j.ajkd.2007.12.002

American Journal of Kidney Diseases
Volume 51, Issue 3 , Pages 445-454 , March 2008

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