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Volume 52, Issue 1 , Pages 181-187 , July 2008

Spurious Elevation in Serum Creatinine Caused by Ingestion of Nitromethane: Implication for the Diagnosis and Treatment of Methanol Intoxication

Anjay Rastogi, MD
- Division of Nephrology, UCLA Center for Health Sciences and David Geffen School of Medicine, Los Angeles, CA
Brandon Itagaki, MD
- Department of Medicine, UCLA Center for Health Sciences and David Geffen School of Medicine, Los Angeles, CA
Meera Bajwa, MD
- Division of Nephrology, UCLA Center for Health Sciences and David Geffen School of Medicine, Los Angeles, CA
Jeffrey A. Kraut, MD
- Medical and Research Services, VHAGLA Healthcare System, Los Angeles, CA
- UCLA Membrane Biology Laboratory, VHAGLA Healthcare System, Los Angeles, CA
- Division of Nephrology, VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, CA.
- Address correspondence to Jeffrey A. Kraut, MD, Division of Nephrology, VHAGLA Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073.

Received 2 October 2007 ,Accepted 12 December 2007.

Metabolic pathway for methanol. Methanol is metabolized to formaldehyde under the influence of the enzyme alcohol dehydrogenase (ADH). Formaldehyde is then converted to formic acid under the influence

Metabolic pathway for methanol. Methanol is metabolized to formaldehyde under the influence of the enzyme alcohol dehydrogenase (ADH). Formaldehyde is then converted to formic acid under the influence of formaldehyde dehydrogenase (FMD) and finally to carbon dioxide (CO₂) and water (H₂O). Abbreviations: NAD, nicotinamide-adenine dinucleotide; NADH, the reduced form of NAD.
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