American Journal of Kidney Diseases
Volume 51, Issue 4, Supplement 2 , Pages S56-S68 , April 2008

Trends in Mineral Metabolism: Kidney Early Evaluation Program (KEEP) and the National Health and Nutrition Examination Survey (NHANES) 1999-2004

  • Joseph A. Vassalotti, MD

      Affiliations

    • National Kidney Foundation, New York, NY
    • Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY
    • Corresponding Author InformationAddress correspondence to Joseph A. Vassalotti, MD, Chief Medical Officer, National Kidney Foundation, Mount Sinai School of Medicine, One Gustave L. Levy Pl, Nephrology Box 1243, New York, NY 10029-6574.
  • ,
  • Jaime Uribarri, MD

      Affiliations

    • Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY
  • ,
  • Shu-Cheng Chen, MS

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
  • ,
  • Suying Li, PhD

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
  • ,
  • Changchun Wang, MS

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
  • ,
  • Allan J. Collins, MD, FACP

      Affiliations

    • Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN
    • Department of Medicine, University of Minnesota, Minneapolis, MN
  • ,
  • Mona S. Calvo, PhD

      Affiliations

    • Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD
  • ,
  • Adam T. Whaley-Connell, MD

      Affiliations

    • Department of Medicine, Division of Nephrology, University of Missouri-Columbia School of Medicine, Columbia, MO
  • ,
  • Peter A. McCullough, MD, MPH

      Affiliations

    • Department of Medicine, Divisions of Cardiology, Nutrition, and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI
  • ,
  • Keith C. Norris, MD

      Affiliations

    • Charles R. Drew University of Medicine and Science, Los Angeles, CA
    • David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
  • ,
  • Kidney Early Evaluation Program Investigators

Received 16 November 2007 ,Accepted 31 December 2007.

References 

  1. Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis. 1998;31:607–617
  2. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol. 2004;15:2208–2218
  3. Kalantar-Zadeh K, Kuwae N, Regidor DL, et al. Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int. 2006;70:771–780
  4. Melamed ML, Eustace JA, Plantinga L, et al. Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: A longitudinal study. Kidney Int. 2006;70:351–357
  5. Young EW, Akiba T, Albert JM, et al. Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2004;44:34–38
  6. Young EW, Albert JM, Satayathum S, et al. Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2005;67:1179–1187
  7. Kestenbaum B, Sampson JN, Rudser KD, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol. 2005;16:520–528
  8. Norris KC, Greene T, Kopple J, et al. Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease. J Am Soc Nephrol. 2006;17:2928–2936
  9. London GM, Guerin AP, Verbeke FH. Mineral metabolism and arterial functions in end-stage renal disease: Potential role of 25-hydroxyvitamin D deficiency. J Am Soc Nephrol. 2007;18:613–620
  10. Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478–1483
  11. Moe SM. Vascular calcification: Hardening of the evidence. Kidney Int. 2006;70:1535–1537
  12. Dhingra R, Sullivan LM, Fox CS, et al. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med. 2007;167:879–885
  13. Brown WW, Collins A, Chen SC, et al. Identification of persons at high risk for kidney disease via targeted screening: The NKF Kidney Early Evaluation Program. Kidney Int Suppl. 2003;83:S50–S55
  14. Jurkovitz CT, Qiu Y, Wang C, Gilbertson DT, Brown WW. The Kidney Early Evaluation Program (KEEP): Program design and demographic characteristics of the population. Am J Kidney Dis. 2008;51(suppl 2):S3–S12
  15. Stevens LA, Stoycheff N. Standardization of serum creatinine and estimated glomerular filtration rate in the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2008;51(suppl 2):S77–S82
  16. Chobanian AV, Bakris GL, Black HR, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–1252
  17. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Am J Kidney Dis. 2003;42(suppl 3):S1–S201
  18. Kates DM, Sherrard DJ, Andress DL. Evidence that serum phosphate is independently associated with serum PTH in patients with chronic renal failure. Am J Kidney Dis. 1997;30:809–813
  19. Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease. Kidney Int. 2007;71:31–38
  20. Craver L, Marco MP, Martinez I, et al. Mineral metabolism parameters throughout chronic kidney disease stages 1-5—Achievement of K/DOQI target ranges. Nephrol Dial Transplant. 2007;22:1171–1176
  21. Hsu CY, Chertow GM. Elevations of serum phosphorus and potassium in mild to moderate chronic renal insufficiency. Nephrol Dial Transplant. 2002;17:1419–1425
  22. Gupta A, Kallenbach LR, Zasuwa G, Divine GW. Race is a major determinant of secondary hyperparathyroidism in uremic patients. J Am Soc Nephrol. 2000;11:330–334
  23. Kovesdy CP, Ahmadzadeh S, Anderson JE, Kalantar-Zadeh K. Obesity is associated with secondary hyperparathyroidism in men with moderate and severe chronic kidney disease. Clin J Am Soc Nephrol. 2007;2:1024–1029
  24. Schwarz S, Trivedi BK, Kalantar-Zadeh K, Kovesdy CP. Association of disorders in mineral metabolism with progression of chronic kidney disease. Clin J Am Soc Nephrol. 2006;1:825–831
  25. US Renal Data System. USRDS 2007 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disorders; 2007;
  26. Arbor Research Collaborative for Health: 2006 End Stage Renal Disease Clinical Performance Measures Reliability Report. http://www.cms.hhs.gov/CPMProject/02_MeasuresandDataCollection.asp#TopOfPageAccessed February 1, 2008
  27. Moe S, Drueke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–1953
  28. Souberbielle JC, Boutten A, Carlier MC, et al. Inter-method variability in PTH measurement: Implication for the care of CKD patients. Kidney Int. 2006;70:345–350
  29. Martinez I, Saracho R, Montenegro J, Llach F. The importance of dietary calcium and phosphorous in the secondary hyperparathyroidism of patients with early renal failure. Am J Kidney Dis. 1997;29:496–502

 A list of the members of the Kidney Early Evaluation Program Investigators appears at the end of this article.

PII: S0272-6386(08)00006-1

doi: 10.1053/j.ajkd.2007.12.018

American Journal of Kidney Diseases
Volume 51, Issue 4, Supplement 2 , Pages S56-S68 , April 2008