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American Journal of Kidney Diseases
Volume 51, Issue 4
, Pages 678-690
, April 2008
Heme Oxygenase 1: Does It Have a Role in Renal Cytoprotection?
References
- . The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury. Am J Physiol Renal Physiol. 2004;286:F425–F441
- . The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med. 2004;37:1097–1104
- . The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A. 1968;61:748–755
- . The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517–554
- Characterization of rat heme oxygenase-3 gene (Implication of processed pseudogenes derived from heme oxygenase-2 gene). Gene. 2004;336:241–250
- . Chromosomal localization of the human heme oxygenase genes: Heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3. Genomics. 1994;20:513–516
- . Heme oxygenase: Protective gene or Trojan horse. Nat Med. 1998;4:1364–1365
- . How many transcription factors does it take to turn on the heme oxygenase-1 gene?. Am J Respir Cell Mol Biol. 2007;36:166–174
- JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem. 2007;282:6875–6886
- . The chemistry and biology of left-handed Z-DNA. Annu Rev Biochem. 1984;53:791–846
- . d(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription. Nucleic Acids Res. 1990;18:1595–1601
- Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet. 2000;66:187–195
- Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet. 2002;111:1–8
- Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood. 2003;102:1619–1621
- Stress protein-induced immunosuppression: Inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transpl Immunol. 1998;6:84–93
- Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J Biol Chem. 2003;278:9125–9133
- Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem. 1997;272:5375–5381
- . NO-mediated activation of heme oxygenase: Endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol. 1996;270:H107–H114
- . Oxygen tension regulates heme oxygenase-1 gene expression in mammalian cell lines. Cell Biochem Funct. 1998;16:183–193
- . Transcriptional regulation of heme oxygenases by HIF-1alpha in renal medullary interstitial cells. Am J Physiol Renal Physiol. 2001;281:F900–F908
- . Hypoxia differentially regulates stress proteins in cultured cardiomyocytes: Role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection. Cardiovasc Res. 2000;46:139–150
- Paradoxical enhancement of oxidative cell injury by overexpression of heme oxygenase-1 in an anchorage-dependent cell ECV304. J Cell Biochem. 2004;93:552–562
- Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest. 1992;90:267–270
- . The heme synthesis and degradation pathways: Role in oxidant sensitivity (Heme oxygenase has both pro- and antioxidant properties). Free Radic Biol Med. 2000;28:289–309
- Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme oxygenase-1. Kidney Int. 2001;59:106–117
- . Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney Int. 2001;60:2181–2191
- Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003;9:183–190
- Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation. Diabetes. 2002;51:994–999
- . Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: Differential effects of haem domain ligands. Biochem J. 2001;358:201–208
- Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000;6:422–428
- Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J Immunol. 2004;172:4744–4751
- Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med. 2000;192:1015–1026
- Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood. 2002;99:4443–4448
- Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J Immunol. 2004;172:1220–1226
- . Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. Am J Physiol. 1999;277:F882–F889
- . A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta. 1993;1158:189–193
- . Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. Am J Pathol. 1995;147:782–789
- . Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat Med. 1996;2:87–90
- Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999;103:129–135
- . Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry. 1992;31:6627–6631
- . Oxidant preconditioning protects human proximal tubular cells against lethal oxidant injury via p38 MAPK and heme oxygenase-1. Am J Nephrol. 2003;23:324–333
- . Heme oxygenase modulates selectin expression in different regional vascular beds. Am J Physiol Heart Circ Physiol. 2000;278:H1613–H1617
- . Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: Therapeutic opportunities and controversies. Microcirculation. 2003;10:247–257
- MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates. Kidney Int. 2005;68:611–622
- . Heme: A determinant of life and death in renal tubular epithelial cells. Am J Physiol Renal Physiol. 2004;286:F370–F377
- Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J. 2005;19:458–460
- Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood. 2005;106:1694–1702
- Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction. Arterioscler Thromb Vasc Biol. 2005;25:155–160
- . Intracellular targets in heme protein-induced renal injury. Kidney Int. 1998;53:100–111
- . The renal handling of hemoglobin (II. Catabolism). J Exp Med. 1969;129:925–934
- . The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol. 2000;156:1527–1535
- . Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity. Arch Biochem Biophys. 1976;176:91–102
- Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med. 2000;28:809–817
- . Ischaemia-reperfusion injury. Br J Surg. 1994;81:637–647
- Hemolysate pretreatment ameliorates ischemic acute renal injury in rats. Nephron. 2002;92:407–413
- Tin chloride pretreatment prevents renal injury in rats with ischemic acute renal failure. Crit Care Med. 2002;30:1512–1522
- Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol. 2004;287:F979–F989
- Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant. 2005;5:282–291
- . Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappaB. Kidney Int. 2002;62:1160–1170
- In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int. 2004;65:834–845
- Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury. J Am Soc Nephrol. 2003;14:1066–1071
- CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol. 2003;14:2503–2515
- . Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int. 1998;53:672–678
- . Nitric oxide induces heme oxygenase-1 gene expression in mesangial cells. Kidney Int. 1999;55:1734–1739
- . Glomerular inflammation induces resistance to tubular injury in the rat (A novel form of acquired, heme oxygenase-dependent resistance to renal injury). J Clin Invest. 1996;98:2139–2145
- . Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. J Am Soc Nephrol. 2002;13:991–999
- Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction. Kidney Int. 1999;56:1004–1013
- . Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis. Am J Physiol. 1994;266:F926–F933
- . The paradox of the renin-angiotensin system in chronic renal disease. Kidney Int. 1994;45:403–410
- . Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro. Kidney Int. 2000;58:144–152
- . Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis. J Immunol. 1998;161:430–439
- . Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Am J Physiol Renal Physiol. 2002;283:F1075–F1084
- . Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J Biol Chem. 2000;275:40904–40909
- Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency. Am J Kidney Dis. 2000;35:863–870
- Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases. Kidney Int. 2001;60:1858–1866
- . Association of functional heme oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy. Nephrol Dial Transplant. 2008;23:608–611
- . Deleterious effects of delayed graft function in cadaveric renal transplant recipients independent of acute rejection. Transplantation. 1998;66:1697–1701
- . Apoptosis and inflammation in renal reperfusion injury. Transplantation. 2002;73:1693–1700
- The “injury response”: A concept linking nonspecific injury, acute rejection, and long-term transplant outcomes. Transplant Proc. 1997;29:79–81
- . Molecular and cellular events associated with ischemia/reperfusion injury. Ann Transplant. 2000;5:29–35
- . Hypothesis: Is renal allograft rejection initiated by the response to injury sustained during the transplant process?. Kidney Int. 1999;55:2157–2168
- . Ischemic acute tubular necrosis induces an extensive local cytokine response (Evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10). Transplantation. 1995;59:565–572
- . The relevance of induced class II HLA antigens and macrophage infiltration in early renal allograft biopsies. Transplantation. 1989;48:238–243
- . Migration patterns of dendritic leukocytes (Implications for transplantation). Transplantation. 1990;49:1–7
- . Chronic renal allograft dysfunction: The role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol. 2004;15:390–397
- . Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy. Am J Transplant. 2005;5:500–509
- Apoptosis in human kidney allografts. Transplant Proc. 1996;28:1226–1227
- . Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts. Kidney Int. 2003;63:1564–1573
- Induction of carbon monoxide in the donor reduces graft immunogenicity and chronic graft deterioration. Transplant Proc. 2005;37:379–381
- Induction of heme-oxygenase-1 prevents ischemia/reperfusion injury and improves long-term graft outcome in rat renal allografts. Transplant Proc. 2001;33:1286–1287
- Improvement of long-term function in renal allografts from ‘marginal donors’ following the induction of heme-oxygenase-1. Transplant Proc. 2001;33:1160–1161
- Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol. 2003;14:745–754
- RDP1258, a new rationally designed immunosuppressive peptide, prolongs allograft survival in rats: Analysis of its mechanism of action. Mol Med. 1999;5:820–832
- Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy. Am J Physiol Renal Physiol. 2006;290:F324–F334
- Peritransplant treatment with cobalt protoporphyrin attenuates chronic renal allograft rejection. Transpl Int. 2005;18:341–349
- Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 2001;166:4185–4194
- Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation. 2002;73:287–292
- Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J. 2004;18:771–772
- . Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med. 1998;4:1392–1396
- Prevention of chronic deterioration of heart allograft by recombinant adeno-associated virus-mediated heme oxygenase-1 gene transfer. Circulation. 2003;107:2623–2629
- Induction of long-term cardiac allograft survival by heme oxygenase-1 gene transfer. Gene Ther. 2004;11:701–710
- Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003;171:1572–1580
- Heme oxygenase-1 overexpression protects rat livers from ischemia/reperfusion injury with extended cold preservation. Am J Transplant. 2001;1:121–128
- Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J Clin Invest. 1999;104:1631–1639
- Heme oxygenase-1 alleviates ischemia/reperfusion injury in aged liver. World J Gastroenterol. 2005;11:690–694
- . Pretreatment of small bowel isograft donors with cobalt-protoporphyrin decreases preservation injury. Transplant Proc. 1999;31:585–586
- Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol. 2003;163:231–242
- Heme-oxygenase-1 expression correlates with severity of acute cellular rejection in lung transplantation. J Am Coll Surg. 2004;198:945–952
- Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes. 2001;50:1983–1991
- Effect of brain death on gene expression and tissue activation in human donor kidneys. Transplantation. 2004;78:978–986
- Differential expression of heme oxygenase-1 and vascular endothelial growth factor in cadaveric and living donor kidneys after ischemia-reperfusion. J Am Soc Nephrol. 2003;14:3278–3287
- On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol. 2005;16:1542–1548
- Expression of protective genes in human renal allografts: A regulatory response to injury associated with graft rejection. Transplantation. 2002;73:1079–1085
- Compartment-specific quantitative gene expression analysis after laser microdissection from archival renal allograft biopsies. Clin Nephrol. 2005;63:193–201
- Donor heme oxygenase-1 genotype is associated with renal allograft function. Transplantation. 2004;77:538–542
- Fundamental role for HO-1 in the self-protection of renal allografts. Am J Transplant. 2004;4:811–818
- . Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes. Am J Transplant. 2007;7:908–913
- Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation. J Heart Lung Transplant. 2005;24:493–497
- Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy. J Heart Lung Transplant. 2005;24:1600–1605
- Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler Thromb Vasc Biol. 2002;22:1680–1685
- A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. Thromb Haemost. 2004;91:155–161
- Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients. Kidney Int. 2006;69:165–172
- . Problems of reporting genetic associations with complex outcomes. Lancet. 2003;361:865–872
- Impact of donor dopamine on immediate graft function after kidney transplantation. Am J Transplant. 2004;4:419–426
- . Preconditioning strategies to limit graft immunogenicity and cold ischemic organ injury. J Invest Med. 2004;52:323–329
- . Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. Transplantation. 2006;81:623–626
- Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: A randomized placebo controlled trial. Transplantation. 2005;80:1556–1559
- . Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J. 2006;273:2345–2356
- . Dialysis membrane-induced oxidative stress: Role of heme oxygenase-1. Nephron Exp Nephrol. 2007;105:e24–e32
Originally published online as doi:10.1053/j.ajkd.2007.11.033 on March 3, 2008.
PII: S0272-6386(08)00050-4
doi: 10.1053/j.ajkd.2007.11.033
© 2008 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
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American Journal of Kidney Diseases
Volume 51, Issue 4
, Pages 678-690
, April 2008
