American Journal of Kidney Diseases
Volume 51, Issue 6 , Pages 987-995 , June 2008

Variation in Serum and Plasma PTH Levels in Second-Generation Assays in Hemodialysis Patients: A Cross-sectional Study

  • Dominique Joly, MD, PhD

      Affiliations

    • Service de Néphrologie, Laboratoire d'Explorations Fonctionnelles and Inserm Unit 845, Hôpital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (APHP), Université Paris-Descartes
    • ,
  • Tilman B. Drueke, MD, PhD

      Affiliations

    • Service de Néphrologie, Laboratoire d'Explorations Fonctionnelles and Inserm Unit 845, Hôpital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (APHP), Université Paris-Descartes
    • ,
  • Corinne Alberti, MD, PhD

      Affiliations

    • Hôpital Robert Debré, APHP and INSERM, CIE 5, F-75019, Université Paris-Descartes and Inserm Unit 872, Paris
    • ,
  • Pascal Houillier, MD, PhD

      Affiliations

    • Hôpital Européen Georges Pompidou, APHP, Université Paris-Descartes and Inserm Unit 872, Paris
    • ,
  • Ethel Lawson-Body, PhD

      Affiliations

    • Service de Néphrologie, Laboratoire d'Explorations Fonctionnelles and Inserm Unit 845, Hôpital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (APHP), Université Paris-Descartes
    • Hôpital de Gonnesse, Gonnesse, France
    • ,
  • Kevin J. Martin, MB, Bch

      Affiliations

    • Division of Nephrology, Saint Louis University, St Louis, MO
    • ,
  • Catherine Massart, PhD

      Affiliations

    • CHU Pontchaillou, Rennes, France
    • ,
  • Sharon M. Moe, MD

      Affiliations

    • Indiana University School of Medicine and Roudebush VAMC, Indianapolis, IN
    • ,
  • Marie Monge, PhD

      Affiliations

    • Laboratoire Pasteur CERBA, St Ouen l'Aumône, France.
    • ,
  • Jean-Claude Souberbielle, PhD

      Affiliations

    • Service de Néphrologie, Laboratoire d'Explorations Fonctionnelles and Inserm Unit 845, Hôpital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (APHP), Université Paris-Descartes
    • Corresponding Author InformationAddress correspondence to Jean-Claude Souberbielle, PhD, Hôpital Necker-Enfants Malades, Laboratoire d'explorations fonctionnelles, 161 rue de Sèvres, F-75743 Paris Cedex 15, France.

Received 3 August 2007 ,Accepted 30 January 2008.

References 

  1. National Kidney Foundation. K/DOQI Guidelines for the Management of Renal Osteodystrophy. Am J Kidney Dis. 2003;42(suppl 3):S1–S201
  2. Souberbielle JC, Boutten A, Carlier MC, et al. Inter-method variability in PTH measurement: Implication for the care of CKD patients. Kidney Int. 2006;70:345–350
  3. Cantor T, Yang Z, Caraini N, Ilamathi E. Lack of comparability of intact parathyroid hormone measurements among commercial assays for end-stage renal disease patients: Implication for treatment decisions. Clin Chem. 2006;52:1711–1716
  4. Schmitt CP, Homme M, Schaefer F. Structural organization and biological relevance of oscillatory parathyroid hormone secretion. Pediatr Nephrol. 2005;20:346–351
  5. Twoney PJ, Whitlock T, Pledger DR. Differences between serum and plasma for intact parathyroid hormone measurement in patients with chronic renal failure in routine clinical practice. J Clin Pathol. 2005;58:1000–1001
  6. Holmes D, Levin A, Forer B, Rosenberg F. Preanalytical influences on DPC Imulite 2000 intact PTH assays of plasma and serum from dialysis patients. Clin Chem. 2005;51:915–917
  7. Glendenning P, Laffer L, Weber H, Musk A, Vasikaran S. Parathyroid hormone is more stable in EDTA plasma than in serum. Clin Chem. 2002;48:766–767
  8. Gao P, Scheibel S, D'Amour P, et al. Development of a novel immunoradiometric assay exclusively for biologically active parathyroid hormone 1-84: Implication for accurate assessment of parathyroid function. J Bone Miner Res. 2001;16:605–661
  9. Cavalier E, Delanaye P, Carlisi A, Krzesinski JM, Chapelle JP. Stability of intact parathyroid hormone in samples from hemodialysis patients. Kidney Int. 2007;72:370–372
  10. Omar H, Chamberlin A, Walker V, Wood PJ. Immulite 2000 parathyroid hormone assay: Stability of parathyroid hormone in EDTA blood kept at room temperature for 48h. Ann Clin Biochem. 2001;38:561–563
  11. Glendenning P, Musk A, Taranto M, Vasikaran S. Preanalytical factors in the measurement of intact parathyroid hormone with the DPC IMMULITE assay. Clin Chem. 2002;48:566–567
  12. Sherrard DJ, Hercz G, Pei Y, et al. The spectrum of bone disease in end-stage renal failure—An evolving disorder. Kidney Int. 1993;43:436–442
  13. Hercz G, Pei Y, Greenwood C, et al. Aplastic osteodystrophy without aluminium: The role of “suppressed” parathyroid function. Kidney Int. 1993;44:860–866
  14. Wang M, Hercz G, Sherrard D, et al. Relationship between intact 1-84 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity. Am J Kidney Dis. 1995;26:836–844
  15. Cantor T. Parathyroid hormone assay drift: An unappreciated problem in dialysis patient management. Semin Dial. 2005;18:359–364
  16. Moe S, Drüeke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: A proposal statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–1953

 Originally published online as doi:10.1053/j.ajkd.2008.01.017 on April 7, 2008.

PII: S0272-6386(08)00125-X

doi: 10.1053/j.ajkd.2008.01.017

American Journal of Kidney Diseases
Volume 51, Issue 6 , Pages 987-995 , June 2008

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