American Journal of Kidney Diseases
Volume 51, Issue 5 , Pages 789-795 , May 2008

Pharmacodynamics of Unfractionated Heparin During and After a Hemodialysis Session

  • Philippe Brunet, MD

      Affiliations

    • Centre de Néphrologie et de Transplantation Rénale Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France
    • Corresponding Author InformationAddress correspondence to Philippe Brunet, MD, Centre de Néphrologie et de Transplantation rénale, Hôpital de la Conception, 147 Bd Baille, 13005 Marseille, France.
    • ,
  • Nicolas Simon, MD

      Affiliations

    • Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine, Marseille, France
    • ,
  • Adriana Opris, MD

      Affiliations

    • Centre de Néphrologie et de Transplantation Rénale Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France
    • ,
  • Valérie Faure, MD

      Affiliations

    • Centre de Néphrologie et de Transplantation Rénale Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France
    • ,
  • Anne-Marie Lorec-Penet, PharmD

      Affiliations

    • Laboratoire Central Hôpital Sainte-Marguerite, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
    • ,
  • Henri Portugal, PharmD

      Affiliations

    • Laboratoire Central Hôpital Sainte-Marguerite, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
    • ,
  • Bertrand Dussol, MD

      Affiliations

    • Centre de Néphrologie et de Transplantation Rénale Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France
    • ,
  • Yvon Berland, MD

      Affiliations

    • Centre de Néphrologie et de Transplantation Rénale Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France

Received 30 May 2007 ,Accepted 26 December 2007.

References 

  1. Schrader J, Valentin R, Tonnis HJ, et al. Low molecular weight heparin in hemodialysis and hemofiltration patients. Kidney Int. 1985;28:823–829
  2. Guillet B, Simon N, Sampol JJ, et al. Pharmacokinetics of the low molecular weight heparin enoxaparin during 48 h after bolus administration as an anticoagulant in haemodialysis. Nephrol Dial Transplant. 2003;18:2348–2353
  3. Boneu B, Caranobe C, Cadroy Y, et al. Pharmacokinetic studies of standard unfractionated heparin, and low molecular weight heparins in the rabbit. Semin Thromb Hemost. 1988;14:18–27
  4. Hirsh J, Raschke R. Heparin and low-molecular-weight heparin: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(suppl 3):S188–S203
  5. Goudable C, Ton That H, Damani A, et al. Low molecular weight heparin half life is prolonged in haemodialysed patients. Thromb Res. 1986;43:1–5
  6. Wilhelmsson S, Lins LE. Heparin elimination and hemostasis in hemodialysis. Clin Nephrol. 1984;22:303–306
  7. Lim W, Cook DJ, Crowther MA. Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: A meta-analysis of randomized trials. J Am Soc Nephrol. 2004;15:3192–3206
  8. Sonawane S, Kasbekar N, Berns JS. The safety of heparins in end-stage renal disease. Semin Dial. 2006;19:305–310
  9. In:  Beal SL,  Sheiner LB editor. NONMEM Users Guides (1989-98). Hanover, MD: GloboMax LLC; 1998;
  10. Farrell PC, Ward RA, Schindhelm K, Gotch F. Precise anticoagulation for routine hemodialysis. J Lab Clin Med. 1978;92:164–176
  11. Smith BP, Ward RA, Brier ME. Prediction of anticoagulation during hemodialysis by population kinetics and an artificial neural network. Artif Organs. 1998;22:731–739
  12. Ouseph R, Brier ME, Ward RA. Improved dialyzer reuse after use of a population pharmacodynamic model to determine heparin doses. Am J Kidney Dis. 2000;35:89–94
  13. de Swart CA, Nijmeyer B, Roelofs JM, Sixma JJ. Kinetics of intravenously administered heparin in normal humans. Blood. 1982;60:1251–1258
  14. Teien AN, Bjoornson J. Heparin elimination in uraemic patients on haemodialysis. Scand J Haematol. 1976;17:29–35
  15. Kandrotas RJ, Gal P, Douglas JB, Deterding J. Pharmacokinetics and pharmacodynamics of heparin during hemodialysis: Interpatient and intrapatient variability. Pharmacotherapy. 1990;10:349–355
  16. Ouseph R, Ward RA. Anticoagulation for intermittent hemodialysis. Semin Dial. 2000;13:181–187
  17. Mingardi G, Perico N, Pusineri F, et al. Heparin for hemodialysis: Practical guidelines for administration and monitoring. Int J Artif Organs. 1984;7:269–274

PII: S0272-6386(08)00159-5

doi: 10.1053/j.ajkd.2007.12.040

American Journal of Kidney Diseases
Volume 51, Issue 5 , Pages 789-795 , May 2008

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