American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 216-226 , August 2008

Albuminuria and Dementia in the Elderly: A Community Study

  • Joshua I. Barzilay, MD

      Affiliations

    • Kaiser Permanente of Georgia, Tucker, GA
    • Division of Endocrinology, Emory University School of Medicine, Atlanta, GA
    • Corresponding Author InformationAddress correspondence to Joshua I. Barzilay, MD, Kaiser Permanente of Georgia, 200 Crescent Center Pkwy, Tucker, GA 30084.
    • ,
  • Annette L. Fitzpatrick, PhD

      Affiliations

    • Department of Epidemiology, University of Washington, Seattle, WA
    • ,
  • Jose Luchsinger, MD, MPH

      Affiliations

    • Department of Medicine and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY
    • ,
  • Sevil Yasar, MD

      Affiliations

    • Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD
    • ,
  • Charles Bernick, MD

      Affiliations

    • Department of Neurology, University of Nevada School of Medicine, Reno, NV
    • ,
  • Nancy S. Jenny, PhD

      Affiliations

    • Department of Pathology, University of Vermont, Burlington, VT
    • ,
  • Lewis H. Kuller, MD, DrPH

      Affiliations

    • Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.

Received 8 July 2007 ,Accepted 26 December 2007.

References 

  1. Farkas E, Luiten PGM. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol. 2001;64:575–611
  2. de la Torre JC. Alzheimer disease as a vascular disorder: Nosological evidence. Stroke. 2002;33:1152–1162
  3. Wong TY, Klein R, Sharrett AR, et al. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: The Atherosclerosis Risk in Communities Study. Stroke. 2002;33:1487–1492
  4. Baker ML, Larsen EK, Kuller LH, et al. Retinal microvascular signs, cognitive function, and dementia in older persons (The Cardiovascular Health Study). Stroke. 2007;38:2041–2047
  5. Barzilay JI, Peterson D, Cushman M, et al. The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: The Cardiovascular Health Study. Am J Kidney Dis. 2004;44:25–34
  6. Mauer SM, Steffes MW, Ellis EN, Sutherland DE, Brown DM, Goetz FC. Structural-functional relationships in diabetic nephropathy. J Clin Invest. 1984;74:1143–1155
  7. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: Design and rationale. Ann Epidemiol. 1991;1:263–276
  8. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48:314–318
  9. Brandt J, Spencer M, Folstein M. The Telephone Interview for Cognitive Status. Neuropsychiat Neuropsychol Behav Neurol. 1988;1:111–117
  10. Jorm AF, Korten AE. Assessment of cognitive decline in the elderly by informant interview. Br J Psychiatry. 1988;152:209–213
  11. Kuller LH, Shemanski L, Manolio T, et al. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke. 1998;29:388–398
  12. Fitzpatrick AL, Kuller LH, Ives DG, et al. Incidence and prevalence of dementia in the Cardiovascular Health Study. J Am Geriatr Soc. 2004;52:195–204
  13. Lopez OL, Kuller LH, Becker JT, et al. Classification of vascular dementia in the Cardiovascular Health Study Cognition Study. Neurology. 2005;64:1539–1547
  14. Lopez OL, Kuller LH, Fitzpatrick A, Ives D, Becker JT, Beauchamp N. Evaluation of dementia in the Cardiovascular Health Cognition Study. Neuroepidemiology. 2003;22:1–12
  15. Lopez OL, Jagust WJ, DeKosky ST, et al. Prevalence and classification of mild cognitive impairment in the Cardiovascular Cognition Study. Arch Neurol. 2003;60:1385–1389
  16. McKhann G, Drachman DA, Folstein MF, et al. NINCDS-ADRDA Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  17. Chui HC, Victoroff JI, Margolin D, et al. ADDTC Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology. 1992;42:473–480
  18. Román GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: Diagnostic criteria for research studies (Report of the NINDS-AIREN International Workshop). Neurology. 1993;43:250–260
  19. Bryan RN, Manolio TA, Schertz LD, et al. A method of using MR to evaluate the effects of cardiovascular disease on the brain: The Cardiovascular Health Study. AJNR Am J Neuroradiol. 1994;15:1625–1633
  20. Kuller LH, Longstreth WT, Arnold AM, Bernick C, Bryan RN, Beauchamp NJ. White matter hyperintensity on cranial magnetic resonance imaging (A predictor of stroke). Stroke. 2004;35:1821–1825
  21. Christensen PK, Hommel EE, Clausen P, Feldt-Rasmussen B, Parvin HH. Impaired autoregulation of the glomerular filtration rate in patients with nephropathies. Kidney Int. 1999;56:1517–1523
  22. Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: An update. Biochim Biophys Acta. 2007;1772:494–502
  23. Ha H, Kim KH. Pathogenesis of diabetic nephropathy: The role of oxidative stress and protein kinase C. Diabetes Res Clin Pract. 1999;45:147–151
  24. Garg AX, Kiberd BA, Clark WF, Haynes B, Clase CM. Albuminuria and renal insufficiency prevalence guides population screening: Results from NHANES III. Kidney Int. 2002;61:2165–2175
  25. Teo K, Yusuf S, Sleight P, et al. Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials. Am Heart J. 2004;148:52–61
  26. Allen KV, Frier BM, Strachan MW. The relationship between type 2 diabetes and cognitive dysfunction: Longitudinal studies and their methodological limitations. Eur J Pharmacol. 2004;490:169–175
  27. Seliger SL, Siscovick DS, Stehman-Breen CO, et al. Moderate renal impairment and risk of dementia among older adults: The Cardiovascular Health Cognition Study. J Am Soc Nephrol. 2004;15:1904–1911

 Originally published online as doi:10.1053/j.ajkd.2007.12.044 on May 8, 2008.

PII: S0272-6386(08)00175-3

doi: 10.1053/j.ajkd.2007.12.044

American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 216-226 , August 2008

Article Tools

* Image Usage & Resolution