American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 262-271 , August 2008

Recovery of Kidney Function After Acute Kidney Injury in the Elderly: A Systematic Review and Meta-analysis

  • Roland Schmitt, MD

      Affiliations

    • Department of Nephrology, Hannover Medical School, Hannover, Germany
    • Corresponding Author InformationAddress correspondence to Roland Schmitt, MD, Department of Nephrology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany.
    • ,
  • Steven Coca, MD

      Affiliations

    • Yale University School of Medicine, New Haven, CT.
    • ,
  • Mehmet Kanbay, MD

      Affiliations

    • Yale University School of Medicine, New Haven, CT.
    • ,
  • Mary E. Tinetti, MD

      Affiliations

    • Yale University School of Medicine, New Haven, CT.
    • ,
  • Lloyd G. Cantley, MD

      Affiliations

    • Yale University School of Medicine, New Haven, CT.
    • ,
  • Chirag R. Parikh, MD, PhD

      Affiliations

    • Yale University School of Medicine, New Haven, CT.
    • Corresponding Author InformationChirag R. Parikh, MD, PhD, Section of Nephrology, Yale University and VAMC, 950 Campbell Ave, Mail Code 151B, Bldg 35 A, Rm 219, West Haven, CT 06516.

Received 9 November 2007 ,Accepted 11 March 2008.

References 

  1. Harman D. Aging: Overview. Ann N Y Acad Sci. 2001;928:1–21
  2. Spillman BC, Lubitz J. The effect of longevity on spending for acute and long-term care. N Engl J Med. 2000;342:1409–1415
  3. Pascual J, Orofino L, Liano F, et al. Incidence and prognosis of acute renal failure in older patients. J Am Geriatr Soc. 1990;38:25–30
  4. Feest TG, Round A, Hamad S. Incidence of severe acute renal failure in adults: Results of a community based study. BMJ. 1993;306:481–483
  5. Jerkic M, Vojvodic S, Lopez-Novoa JM. The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. Int Urol Nephrol. 2001;32:539–547
  6. Baraldi A, Ballestri M, Rapana R, et al. Acute renal failure of medical type in an elderly population. Nephrol Dial Transplant. 1998;13(suppl 7):S25–S29
  7. de Mendonca A, Vincent JL, Suter PM, et al. Acute renal failure in the ICU: Risk factors and outcome evaluated by the SOFA score. Intensive Care Med. 2000;26:915–921
  8. Choudhury DRD, Levi M. Effect of aging on renal function and disease, in. In:  Brenner B editors. Brenner & Rector's The Kidney. (ed 7). Philadelphia, PA: Saunders; 2004;p. 2305–2340
  9. Gourtsoyiannis N, Prassopoulos P, Cavouras D, Pantelidis N. The thickness of the renal parenchyma decreases with age: A CT study of 360 patients. AJR Am J Roentgenol. 1990;155:541–544
  10. Fliser D. Ren sanus in corpore sano: The myth of the inexorable decline of renal function with senescence. Nephrol Dial Transplant. 2005;20:482–485
  11. Esposito C, Plati A, Mazzullo T, et al. Renal function and functional reserve in healthy elderly individuals. J Nephrol. 2007;20:617–625
  12. Van Den Noortgate N, Mouton V, Lamot C, et al. Outcome in a post-cardiac surgery population with acute renal failure requiring dialysis: Does age make a difference?. Nephrol Dial Transplant. 2003;18:732–736
  13. Lameire N, Matthys E, Vanholder R, et al. Causes and prognosis of acute renal failure in elderly patients. Nephrol Dial Transplant. 1987;2:316–322
  14. Gentric A, Cledes J. Immediate and long-term prognosis in acute renal failure in the elderly. Nephrol Dial Transplant. 1991;6:86–90
  15. Pascual J, Liano F, Ortuno J. The elderly patient with acute renal failure. J Am Soc Nephrol. 1995;6:144–153
  16. Arora P, Kher V, Kohli HS, Sharma RK, Gupta A, Jha R. Acute renal failure in the elderly: Experience from a single centre in India. Nephrol Dial Transplant. 1993;8:827–830
  17. Bhandari S, Turney JH. Survivors of acute renal failure who do not recover renal function. QJM. 1996;89:415–421
  18. Schiffl H. Renal recovery from acute tubular necrosis requiring renal replacement therapy: A prospective study in critically ill patients. Nephrol Dial Transplant. 2006;21:1248–1252
  19. Liano F, Felipe C, Tenorio MT, et al. Long-term outcome of acute tubular necrosis: A contribution to its natural history. Kidney Int. 2007;71:679–686
  20. Kjellstrand CM, Ebben J, Davin T. Time of death, recovery of renal function, development of chronic renal failure and need for chronic hemodialysis in patients with acute tubular necrosis. Trans Am Soc Artif Intern Organs. 1981;27:45–50
  21. Hayden JA, Cote P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144:427–437
  22. Acker CG, Singh AR, Flick RP, Bernardini J, Greenberg A, Johnson JP. A trial of thyroxine in acute renal failure. Kidney Int. 2000;57:293–298
  23. Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: A comprehensive population-based study. J Am Soc Nephrol. 2007;18:1292–1298
  24. Bagshaw SM, Mortis G, Godinez-Luna T, Doig CJ, Laupland KB. Renal recovery after severe acute renal failure. Int J Artif Organs. 2006;29:1023–1030
  25. Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: A prospective, randomized trial. Crit Care Med. 2002;30:2205–2211
  26. Chang JW, Yang WS, Seo JW, Lee JS, Lee SK, Park SK. Continuous venovenous hemodiafiltration versus hemodialysis as renal replacement therapy in patients with acute renal failure in the intensive care unit. Scand J Urol Nephrol. 2004;38:417–421
  27. Elseviers MM, Lins RL, Van der Niepen P, et al. Outcome of different treatment modalities in ARF: Descriptive results. J Am Soc Nephrol. 2004;16:3A;(abstr)
  28. Jacka MJ, Ivancinova X, Gibney RT. Continuous renal replacement therapy improves renal recovery from acute renal failure. Can J Anaesth. 2005;52:327–332
  29. Ji D, Gong D, Xie H, Xu B, Liu Y, Li L. A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure. Chin Med J (Engl). 2001;114:1157–1161
  30. Lins RL, Elseviers MM, Daelemans R. Severity scoring and mortality 1 year after acute renal failure. Nephrol Dial Transplant. 2006;21:1066–1068
  31. Luckraz H, Gravenor MB, George R, et al. Long and short-term outcomes in patients requiring continuous renal replacement therapy post cardiopulmonary bypass. Eur J Cardiothorac Surg. 2005;27:906–909
  32. Marenzi G, Bartorelli AL, Lauri G, et al. Continuous veno-venous hemofiltration for the treatment of contrast-induced acute renal failure after percutaneous coronary interventions. Catheter Cardiovasc Interv. 2003;58:59–64
  33. Morgera S, Kraft AK, Siebert G, Luft FC, Neumayer HH. Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies. Am J Kidney Dis. 2002;40:275–279
  34. Saudan P, Niederberger M, De Seigneux S, et al. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int. 2006;70:1312–1317
  35. Uchino S, Bellomo R, Kellum JA, et al. Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury. Int J Artif Organs. 2007;30:281–292
  36. Uehlinger DE, Jakob SM, Ferrari P, et al. Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol Dial Transplant. 2005;20:1630–1637
  37. Vinsonneau C, Camus C, Combes A, et al. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: A multicentre randomised trial. Lancet. 2006;368:379–385
  38. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  39. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  40. van Houwelingen HC, Arends LR, Stijnen T. Advanced methods in meta-analysis: Multivariate approach and meta-regression. Stat Med. 2002;21:589–624
  41. Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: A comprehensive population-based study. J Am Soc Nephrol. 2007;18:1292–1298
  42. Berendoncks A, Elseviers M, Lins R. Outcome of acute renal failure with different treatment modalities: Long term follow-up. Nephrol Dial Transplant. 2006;21:7A;(abstr)
  43. Cruz DN, Ronco C. Acute kidney injury in the intensive care unit: Current trends in incidence and outcome. Crit Care. 2007;11:149
  44. Bagshaw SM, George C, Bellomo R. Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units. Crit Care. 2007;11:R68
  45. Xue JL, Daniels F, Star RA, et al. Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17:1135–1142
  46. Rodgers H, Staniland JR, Lipkin GW, Turney JH. Acute renal failure: A study of elderly patients. Age Ageing. 1990;19:36–42
  47. Creditor MC. Hazards of hospitalization of the elderly. Ann Intern Med. 1993;118:219–223
  48. Lins RL, Elseviers MM, Daelemans R, et al. Re-evaluation and modification of the Stuivenberg Hospital Acute Renal Failure (SHARF) scoring system for the prognosis of acute renal failure: An independent multicentre, prospective study. Nephrol Dial Transplant. 2004;19:2282–2288

 Originally published online as doi:10.1053/j.ajkd.2008.03.005 on May 22, 2008.R.S. and S.C. contributed equally.

PII: S0272-6386(08)00577-5

doi: 10.1053/j.ajkd.2008.03.005

American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 262-271 , August 2008

Article Tools

* Image Usage & Resolution