American Journal of Kidney Diseases
Volume 52, Issue 1 , Pages 137-139, July 2008

Severe Symptomatic Hyponatremia During Sibutramine Therapy: A Case Report

Unit of Nephrology, Dialysis, and Transplantation, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Received 2 November 2007; accepted 25 February 2008. published online 21 May 2008.

Sibutramine, a serotonin reuptake inhibitor, currently is used in treatment of obesity. The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects. We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman. We hypothesize that sibutramine, through its effect on neurotransmitters, may induce antidiuretic hormone secretion and lead to a syndrome of inappropriate antidiuretic hormone secretion. We advise careful monitoring of water-electrolytic balance during sibutramine therapy.

Index Words: Hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, sibutramine

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 Originally published online as doi:10.1053/j.ajkd.2008.02.361 on May 16, 2008.

PII: S0272-6386(08)00708-7

doi:10.1053/j.ajkd.2008.02.361

American Journal of Kidney Diseases
Volume 52, Issue 1 , Pages 137-139, July 2008

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