American Journal of Kidney Diseases
Volume 52, Issue 4 , Pages 706-715 , October 2008

Pilot Study of Mycophenolate Mofetil for Treatment of Kidney Disease due to Congenital Urinary Tract Disorders in Children

  • Howard Trachtman, MD

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY
    • Corresponding Author InformationAddress correspondence to Howard Trachtman, MD, Schneider Children's Hospital, Division of Nephrology, 269-01 76th Ave, New Hyde Park, NY 11040
    • ,
  • Erica Christen, RN

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Rachel Frank, RN

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Josephine Rini, MD

      Affiliations

    • Division of Nuclear Medicine and Molecular Imaging, North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Christopher Palestro, MD

      Affiliations

    • Division of Nuclear Medicine and Molecular Imaging, North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Eduardo Perelstein, MD

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Cornell University-Weill Medical Center, New York, NY
    • ,
  • Lynne Weiss, MD

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Robert Wood Johnson Medical Center, New Brunswick, NJ
    • ,
  • Freya Tarapore

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Sherwin Fortune

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY
    • ,
  • Judah Horowitz

      Affiliations

    • Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of North Shore-LIJ Health System, New Hyde Park, New York, NY

Received 12 December 2007 ,Accepted 21 March 2008.

References 

  1. Warady BA, Hebert D, Sullivan WEK, Alexander SR, Tejani A. Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents (The 1995 annual report of the North American Pediatric Renal Transplant Cooperative Study). Pediatr Nephrol. 1997;11:49–64
  2. Roth KS, Carter WH, Chan JC. Obstructive uropathy in children: Long-term progression after relief of posterior urethral valve. Pediatrics. 2001;107:1004–1010
  3. Manucha W. Biochemical-molecular markers in unilateral ureteral obstruction. Biocell. 2007;31:1–12
  4. Fujihara CK, Malheiros DM, Zatz R, Noronha IL. Mycophenolate mofetil attenuates renal injury in the remnant kidney. Kidney Int. 1998;54:1510–1519
  5. Romero F, Rodriguez-Iturbe I, Parra G, Gonzalez L, Herrera-Acosta J, Tapia E. Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. Kidney Int. 1999;55:945–955
  6. Remuzzi G, Zoja C, Gagliardini E, Corna D, Abbate M, Benigni A. Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals. J Am Soc Nephrol. 1999;10:1542–1549
  7. Fujihara CK, Noronha IL, Malheiros DM, Antunes GR, De Oliveira IB, Zatz R. Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney. J Am Soc Nephrol. 2000;11:283–290
  8. Allison AC, Eugui EM. Mycophenolate mofetil and its mechanism of action. Immunopharmacology. 2000;47:85–118
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  11. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987;34:571–590
  12. Ardissino G, Vigano S, Testa S, et al. No clear evidence of ACEi efficacy on the progression of chronic kidney disease in children with hypodysplastic nephropathy—Report from the ItalKid Project database. Nephrol Dial Transplant. 2007;22:2525–2530
  13. Silkalns GI, Jeck D, Earon J, et al. Simultaneous measurement of glomerular filtration rate and renal plasma flow using plasma disappearance curves. J Pediatr. 1973;83:749–757
  14. Torgny G, Tengstrom B. The usefulness of 125I-sodium iothalamate as a GFR-indicator in single intravenous injection tests. Upsala J Med Sci. 1978;83:53–63
  15. Bayazit AK, Bayazit Y, Noyan A, Gonlusen G, Anarat A. Comparison of mycophenolate mofetil and azathioprine in obstructive uropathy. Pediatr Nephrol. 2003;18:100–104
  16. Goncalves RG, Biato MA, Colosimo RD, et al. Effects of mycophenolate mofetil and lisinopril on collagen deposition in unilateral ureteral obstruction in rats. Am J Nephrol. 2004;24:527–536
  17. Chevalier RL. Perinatal obstructive uropathy. Semin Perinatol. 2004;28:124–131
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  19. Ettenger R, Sarwal MM. Mycophenolate mofetil in pediatric renal transplantation. Transplant. 2005;80(suppl 2):S201–S210
  20. Ungraithmayr TC, Wiesmayr S, Staskewitz A, et al. German Pediatric Renal Transplantation Study Group Five-year outcome in pediatric patients with mycophenolate mofetil-based renal transplantation. Transplant. 2007;83:900–905
  21. Buratti S, Szer IS, Spencer CH, Bartosh S, Reiff A. Mycophenolate mofetil treatment of severe renal disease in pediatric onset systemic lupus erythematosus. J Rheumatol. 2001;28:2103–2108
  22. Filler G, Hansen M, LeBlanc C, et al. Pharmacokinetics of mycophenolate mofetil for autoimmune diseases in children. Pediatr Nephrol. 2003;18:445–449
  23. Cransberg K, Cornelissen M, Lilien M, Van Hoeck K, Davin JC, Nauta J. Maintenance immunosuppression with mycophenolate mofetil and corticosteroids in pediatric kidney transplantation: Temporary benefit but not without risk. Transplant. 2007;83:1041–1047
  24. Hood KA, Zarembski DG. Mycophenolate mofetil: A unique immunosuppressive agent. Am J Health Syst Pharm. 1997;54:285–294
  25. Seikaly MG, Browne R, Bajaj G, Arrant BS. Limitations of body length/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatr Nephrol. 1996;10:709–711
  26. Seikaly MG, Browne R, Simonds N, Atkins C, Alexander SR. Glomerular filtration rate in children following renal transplantation. Pediatr Transplant. 1998;2:231–235
  27. Schwartz GJ, Furth S, Cole S, Warady B, Munoz A. Glomerular filtration rate via plasma iohexol disappearance: Pilot study for chronic kidney disease in children. Kidney Int. 2006;69:2070–2077
  28. Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 2006;116:288–296
  29. Sakatsume M, Xie Y, Ueno M, et al. Human glomerulonephritis accompanied by active cellular infiltrates shows effector T cells in urine. J Am Soc Nephrol. 2001;12:2636–2644

 Trial Registration: www.clinicaltrials.gov; Study Number: NCT00193635

 Originally published online as doi:10.1053/j.ajkd.2008.03.035 on June 11, 2008.

PII: S0272-6386(08)00768-3

doi: 10.1053/j.ajkd.2008.03.035

American Journal of Kidney Diseases
Volume 52, Issue 4 , Pages 706-715 , October 2008

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