American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 324-330 , August 2008

Effect of Sirolimus on Left Ventricular Hypertrophy in Kidney Transplant Recipients: A 1-Year Nonrandomized Controlled Trial

  • Ernesto Paoletti, MD

      Affiliations

    • Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    • Corresponding Author InformationAddress correspondence to Ernesto Paoletti, MD, Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Lgo R Benzi 10, 16132, Genova, Italy.
    • ,
  • Marco Amidone, MD

      Affiliations

    • Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    • ,
  • Paolo Cassottana, MD

      Affiliations

    • Divisione di Cardiologia, Azienda Ospedaliera Universitaria S Martino, Genova, Italy.
    • ,
  • Maurizio Gherzi, MD

      Affiliations

    • Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    • ,
  • Luigina Marsano, MD

      Affiliations

    • Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy
    • ,
  • Giuseppe Cannella, MD, PhD

      Affiliations

    • Divisione di Nefrologia, Dialisi, e Trapianto, Azienda Ospedaliera Universitaria S Martino, Genova, Italy

Received 1 January 2008 ,Accepted 23 April 2008.

References 

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  2. Hernandez D, Lacalzada J, Salido E, et al. Regression of left ventricular hypertrophy by lisinopril after renal transplantation: Role of ACE gene polymorphism. Kidney Int. 2000;58:889–897
  3. Midtvedt K, Ihlen H, Hartmann A, et al. Reduction of left ventricular mass by lisinopril and nifedipine in hypertensive renal transplant recipients: A prospective randomized double-blind study. Transplantation. 2001;72:107–111
  4. Paoletti E, Cassottana P, Amidone M, Gherzi M, Rolla D, Cannella G. ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: A randomized clinical trial. Am J Kidney Dis. 2007;50:133–142
  5. Shioi T, McMullen JR, Tarnavski O, et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation. 2003;107:1664–1670
  6. McMullen JR, Sherwood MC, Tarnavski O, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation. 2004;109:3050–3055
  7. Gao XM, Wong G, Wang B, et al. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens. 2006;24:1663–1670
  8. Liptak P, Ivanyi B. Primer: Histopathology of calcineurin-inhibitor toxicity in renal allograft. Nat Clin Pract Nephrol. 2006;2:398–404
  9. Ruiz JC, Campistol JM, Grinyo JM, et al. Early cyclosporine A withdrawal in kidney-transplant recipients receiving sirolimus prevents progression of chronic pathologic allograft lesions. Transplantation. 2004;78:1312–1318
  10. Stallone G, Infante B, Schena A, et al. Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients. J Am Soc Nephrol. 2005;16:3755–3762
  11. Oberbauer R, Segoloni G, Campistol JM, et al. Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation. Transplant Int. 2005;18:22–28
  12. National Kidney Foundation. K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease. Am J Kidney Dis. 2004;43(suppl 1):S1–S290
  13. Sahn DJ, De Maria A, Kisslo J, et al. Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements. Circulation. 1978;58:1072–1083
  14. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necroscopy findings. Am J Cardiol. 1986;57:450–458
  15. Zoccali C, Benedetto FA, Mallamaci F, et al. Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis. J Am Soc Nephrol. 2001;12:2768–2774
  16. Ferrara LA, Vaccaro O, Cardoni O, et al. Indexation criteria of left ventricular mass and predictive role of blood pressure and body composition. Am J Hypertens. 2005;18:1263–1265
  17. Ganau A, Devereux RB, Roman MJ, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19:1550–1558
  18. Levey AS, Greene T, Kusek JW, et al. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol. 2000;11(A0828):(abstr)
  19. Cannella G, Paoletti E, Delfino R, Peloso GC, Molinari S, Traverso GB. Regression of left ventricular hypertrophy in hypertensive dialyzed uremic patients on long-term antihypertensive therapy. Kidney Int. 1993;44:881–886
  20. Boluyt MO, Li ZB, Loyd AM, Scalia AF, Cirrincione GM, Jackson RR. The mTOR/p70S6K signaling transduction pathway plays a role in cardiac hypertrophy and influences expression of myosin heavy chain genes in vivo. Cardiovasc Drugs Ther. 2004;18:257–267
  21. Sadoshima J, Izumo S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro (Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy). Circ Res. 1995;77:1040–1052
  22. Amann K, Tyralla K. Cardiovascular changes in chronic renal failure—Pathogenesis and therapy. Clin Nephrol. 2002;58(suppl 1):S62–S72
  23. Mark PB, Johnston N, Groenning BA, et al. Redefinition of uremic cardiomyopathy by contrast-enhanced cardiac magnetic resonance imaging. Kidney Int. 2006;69:1839–1845

 Originally published online as doi:10.1053/j.ajkd.2008.04.018 on June 30, 2008.

 Trial registration: http://controlled-trials.com; study number: ISRCTN54216890.

PII: S0272-6386(08)00866-4

doi: 10.1053/j.ajkd.2008.04.018

American Journal of Kidney Diseases
Volume 52, Issue 2 , Pages 324-330 , August 2008

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