American Journal of Kidney Diseases
Volume 53, Issue 1 , Pages 16-25 , January 2009

Effect of Renin-Angiotensin-Aldosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease: A Post Hoc Analysis of a Randomized Controlled Trial

  • Femke Waanders, MD

      Affiliations

    • Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Vishal S. Vaidya, PhD

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Harry van Goor, PhD

      Affiliations

    • Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Henri Leuvenink, PhD

      Affiliations

    • Deparment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Kevin Damman, MD

      Affiliations

    • Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Inge Hamming, MD, PhD

      Affiliations

    • Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Joseph V. Bonventre, MD, PhD

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Liffert Vogt, MD, PhD

      Affiliations

    • Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Gerjan Navis, MD, PhD

      Affiliations

    • Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationAddress correspondence to Gerjan Navis, MD, PhD, University Medical Center Groningen, Department of Nephrology, PO Box 30.001, 9700 RB Groningen, The Netherlands

Received 17 February 2007 ,Accepted 7 July 2008.

References 

  1. Wang Y, Rangan GK, Tay YC, et al. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kappaB in proximal tubule cells. J Am Soc Nephrol. 1999;10:1204–1213
  2. Morigi M, Macconi D, Zoja C, et al. Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol. 2002;13:1179–1189
  3. Zoja C, Donadelli R, Colleoni S, et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappaB activation. Kidney Int. 1998;53:1608–1615
  4. Tang S, Leung JC, Abe K, et al. Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest. 2003;111:515–527
  5. Eddy AA. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol. 1989;135:719–733
  6. Ruggenenti P, Schieppati A, Remuzzi G. Progression, remission, regression of chronic renal diseases. Lancet. 2001;357:1601–1608
  7. Ruggenenti P, Perna A, Remuzzi G. Retarding progression of chronic renal disease: The neglected issue of residual proteinuria. Kidney Int. 2003;63:2254–2261
  8. Remuzzi G, Perico N, Macia M, et al. The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease. Kidney Int Suppl. 2005;99:S57–S65
  9. Vaidya VS, Ramirez V, Ichimura T, et al. Urinary kidney injury molecule-1: A sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 2006;290:F517–F529
  10. van Timmeren MM, van den Heuvel MC, Bailly V, et al. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007;212:209–217
  11. van Timmeren MM, Bakker SJ, Vaidya VS, et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol. 2006;291:F456–F464
  12. van Timmeren MM, Vaidya VS, van Ree RM, et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation. 2007;84:1625–1630
  13. Vogt L, Waanders F, Boomsma F, et al. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol. 2008;19:999–1007
  14. Liangos O, Perianayagam MC, Vaidya VS, et al. Urinary N-acetyl-β-d-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol. 2007;18:904–912
  15. Han WK, Bailly V, Abichandani R, et al. Kidney injury molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int. 2002;62:237–244
  16. Lockwood TD, Bosmann HB. The use of urinary N-acetyl-beta-glucosaminidase in human renal toxicology (I. Partial biochemical characterization and excretion in humans and release from the isolated perfused rat kidney). Toxicol Appl Pharmacol. 1979;49:323–336
  17. Kramer AB, van Timmeren MM, Schuurs TA, et al: De novo induction of kidney injury molecule-1 (KIM-1) in proteinuria-induced renal damage is reduced by RAAS blockade. Am J Physiol (in press)
  18. de Borst MH, van Timmeren MM, Vaidya VS, et al. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol. 2007;292:F313–F320
  19. Nakao N, Yoshimura A, Morita H, et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial. Lancet. 2003;361:117–124
  20. Lysaght MJ. Maintenance dialysis population dynamics: Current trends and long-term implications. J Am Soc Nephrol. 2002;13(suppl 1):S37–S40
  21. Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41:1–12
  22. Wehrmann M, Bohle A, Bogenschutz O, et al. Long-term prognosis of chronic idiopathic membranous glomerulonephritis (An analysis of 334 cases with particular regard to tubulo-interstitial changes). Clin Nephrol. 1989;31:67–76
  23. Wehrmann M, Bohle A, Held H, et al. Long-term prognosis of focal sclerosing glomerulonephritis (An analysis of 250 cases with particular regard to tubulointerstitial changes). Clin Nephrol. 1990;33:115–122
  24. Bazzi C, Petrini C, Rizza V, et al. Characterization of proteinuria in primary glomerulonephritides (SDS-PAGE patterns: Clinical significance and prognostic value of low molecular weight (“tubular”) proteins). Am J Kidney Dis. 1997;29:27–35
  25. Bazzi C, Petrini C, Rizza V, et al. A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephrotic syndrome. Kidney Int. 2000;58:1732–1741
  26. Bazzi C, Petrini C, Rizza V, et al. Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis. Nephrol Dial Transplant. 2002;17:1890–1896
  27. Hamming I, Navis G, Kocks MJ, et al. ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats. J Pathol. 2006;209:129–139
  28. Zhou Y, Vaidya VS, Brown RP, et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci. 2008;101:159–170
  29. Vaidya VS, Shankar K, Lock EA, et al. Renal injury and repair following S-1, 2 dichlorovinyl-l-cysteine administration to mice. Toxicol Appl Pharmacol. 2003;188:110–121
  30. Wiley RA, Choo HY, Traiger GJ. The effect of nephrotoxic furans on urinary N-acetylglucosaminidase levels in mice. Toxicol Lett. 1982;14:93–96
  31. Tylicki L, Rutkowski P, Renke M, et al. Addition of aldosterone receptor blocker to dual renin-angiotensin-aldosterone blockade leads to limitation of tubulointerstitial injury of kidney. Kidney Int. 2007;72:1164–1165
  32. Yang Y, Ohta K, Shimizu M, et al. Treatment with low-dose angiotensin-converting enzyme inhibitor (ACEI) plus angiotensin II receptor blocker (ARB) in pediatric patients with IgA nephropathy. Clin Nephrol. 2005;64:35–40
  33. Bailly V, Zhang Z, Meier W, et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem. 2002;277:39739–39748
  34. Liu BC, Zhang L, Lv LL, et al. Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease. Am J Nephrol. 2006;26:483–490
  35. Sanders JS, Huitema MG, Hanemaaijer R, et al. Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis. Am J Physiol Renal Physiol. 2007;293:F1927–F1934
  36. Thrailkill KM, Bunn RC, Moreau CS, et al. Matrix metalloproteinase-2 dysregulation in type 1 diabetes. Diabetes Care. 2007;30:2321–2326

 Originally published online as doi:10.1053/j.ajkd.2008.07.021 on September 29, 2008

PII: S0272-6386(08)01192-X

doi: 10.1053/j.ajkd.2008.07.021

American Journal of Kidney Diseases
Volume 53, Issue 1 , Pages 16-25 , January 2009

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