Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid

Glomerulus with a thrombus involving the vascular pole and its arteriole (arrow). Extensive double-contour formation is also noted (arrowhead) (Jones stain; original magnification ×40).

Electron microscopy. Asterick indicate well-developed mesangial interposition. No fibrin tactoids or electron-dense deposits are seen. These findings were seen in all 3 glomeruli studied (original magnification ×3,200).

Electron Microscopy. Asterick indicate messangial interposition and electron lucent expansion of the subendothelial zone (arrow) (original magnification ×3,200).