American Journal of Kidney Diseases
Volume 53, Issue 2 , Pages 346-350 , February 2009

Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid

  • Walter P. Mutter, MD

      Affiliations

    • Renal Division, Beth Israel Deaconess Medical Center, Boston, MA
    • Corresponding Author InformationAddress correspondence to Walter P. Mutter, MD, Dana 517, Renal Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215
    • ,
  • Isaac E. Stillman, MD

      Affiliations

    • Renal Division, Beth Israel Deaconess Medical Center, Boston, MA
    • Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Neera K. Dahl, MD, PhD

      Affiliations

    • Section of Nephrology, Yale University School of Medicine, New Haven, CT

Received 29 January 2008 ,Accepted 28 July 2008.

References 

  1. Frederiksen MC, Bowsher DJ, Ruo TI, et al. Kinetics of epsilon-aminocaproic acid distribution, elimination, and antifibrinolytic effects in normal subjects. Clin Pharmacol Ther. 1984;35:387–393
  2. Manjunath G, Fozailoff A, Mitcheson D, Sarnak MJ. Epsilon-aminocaproic acid and renal complications: Case report and review of the literature. Clin Nephrol. 2002;58:63–67
  3. Humphreys BD, Sharman JP, Henderson JM, et al. Gemcitabine-associated thrombotic microangiopathy. Cancer. 2004;100:2664–2670
  4. Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001;60:831–846
  5. Ponticelli C, Banfi G. Thrombotic microangiopathy after kidney transplantation. Transpl Int. 2006;19:789–794
  6. Qu L, Kiss JE. Thrombotic microangiopathy in transplantation and malignancy. Semin Thromb Hemost. 2005;31:691–699
  7. Ardalan MR. Review of thrombotic microangiopathy (TMA), and post-renal transplant TMA. Saudi J Kidney Dis Transpl. 2006;17:235–244
  8. Harris EN, Chan JK, Asherson RA, Aber VR, Gharavi AE, Hughes GR. Thrombosis, recurrent fetal loss, and thrombocytopenia (Predictive value of the anticardiolipin antibody test). Arch Intern Med. 1986;146:2153–2156
  9. Hughes GR, Harris NN, Gharavi AE. The anticardiolipin syndrome. J Rheumatol. 1986;13:486–489
  10. Rosove MH, Brewer PM. Antiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients. Ann Intern Med. 1992;117:303–308
  11. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughe GR. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med. 1995;332:993–997
  12. Erkan D, Yazici Y, Peterson MG, Sammaritano L, Lockshin MD. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford). 2002;41:924–929
  13. Jain R, Chartash E, Susin M, Furie R. Systemic lupus erythematosus complicated by thrombotic microangiopathy. Semin Arthritis Rheum. 1994;24:173–182
  14. Espinosa G, Bucciarelli S, Cervera R, et al. Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies. Ann Rheum Dis. 2004;63:730–736
  15. Nesher G, Hanna VE, Moore TL, Hersh M, Osborn TG. Thrombotic microangiographic hemolytic anemia in systemic lupus erythematosus. Semin Arthritis Rheum. 1994;24:165–172
  16. Kozmin LD, Shirokova IE, Lisitsina TA, et al. Anti-plasminogen autoantibodies from plasma of patients with systemic lupus erythematosus having anti-phospholipid antibody syndrome: Isolation and some immunochemical properties. Biochemistry (Mosc). 2003;68:339–345
  17. Nochy D, Daugas E, Hill G, Piette JC. [Anti-phospholipid syndrome nephropathy]. Ann Med Interne (Paris). 2003;154:51–58
  18. Tektonidou MG, Sotsiou F, Nakopoulou L, Vlachoyiannopoulos PG, Moutsopoulos HM. Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: Prevalence, clinical associations, and long-term outcome. Arthritis Rheum. 2004;50:2569–2579
  19. Daugas E, Nochy D, Huong DL, et al. Antiphospholipid syndrome nephropathy in systemic lupus erythematosus. J Am Soc Nephrol. 2002;13:42–52
  20. Nochy D, Daugas E, Droz D, et al. The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol. 1999;10:507–518
  21. Moroni G, Ventura D, Riva P, et al. Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis. Am J Kidney Dis. 2004;43:28–36

 Originally published online as doi:10.1053/j.ajkd.2008.07.023 on September 22, 2008.

PII: S0272-6386(08)01195-5

doi: 10.1053/j.ajkd.2008.07.023

American Journal of Kidney Diseases
Volume 53, Issue 2 , Pages 346-350 , February 2009

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