American Journal of Kidney Diseases
Volume 53, Issue 2 , Pages 248-258 , February 2009

Tracking and Determinants of Kidney Size From Fetal Life Until the Age of 2 Years: The Generation R Study

  • J.J. Miranda Geelhoed, MD

      Affiliations

    • The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Bero O. Verburg, MD, PhD

      Affiliations

    • The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Jeroen Nauta, MD, PhD

      Affiliations

    • Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Maarten Lequin, MD, PhD

      Affiliations

    • Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Albert Hofman, MD, PhD

      Affiliations

    • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Henriëtte A. Moll, MD, PhD

      Affiliations

    • Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Jacqueline C.M. Witteman, PhD

      Affiliations

    • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Albertus J. van der Heijden, MD, PhD

      Affiliations

    • Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Eric A.P. Steegers, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Vincent W.V. Jaddoe, MD, PhD

      Affiliations

    • The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    • Corresponding Author InformationAddress correspondence to Vincent W.V. Jaddoe, MD, PhD, The Generation R Study Group (AE-006), Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

Received 4 March 2007 ,Accepted 15 July 2008.

References 

  1. Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation. 1996;94:3246–3250
  2. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2:577–580
  3. Hoy WE, Rees M, Kile E, et al. Low birthweight and renal disease in Australian aborigines. Lancet. 1998;352:1826–1827
  4. Nelson RG, Morgenstern H, Bennett PH. Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus. Am J Epidemiol. 1998;148:650–656
  5. Lackland DT, Bendall HE, Osmond C, Egan BM, Barker DJ. Low birth weights contribute to high rates of early-onset chronic renal failure in the southeastern United States. Arch Intern Med. 2000;160:1472–1476
  6. Ramirez SP, Hsu SI, McClellan W. Low body weight is a risk factor for proteinuria in multiracial southeast Asian pediatric population. Am J Kidney Dis. 2001;38:1045–1054
  7. Zidar N, Avgustin Cavic M, Kenda RB, Ferluga D. Unfavorable course of minimal change nephrotic syndrome in children with intrauterine growth retardation. Kidney Int. 1998;54:1320–1323
  8. Zidar N, Cavic MA, Kenda RB, Koselj M, Ferluga D. Effect of intrauterine growth retardation on the clinical course and prognosis of IgA glomerulonephritis in children. Nephron. 1998;79:28–32
  9. Brenner BM, Chertow GM. Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis. 1994;23:171–175
  10. Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest. 1991;64:777–784
  11. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec. 1992;232:194–201
  12. Langley-Evans SC, Welham SJ, Jackson AA. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci. 1999;64:965–974
  13. Lelievre-Pegorier M, Vilar J, Ferrier ML, et al. Mild vitamin A deficiency leads to inborn nephron deficit in the rat. Kidney Int. 1998;54:1455–1462
  14. Bassan H, Trejo LL, Kariv N, et al. Experimental intrauterine growth retardation alters renal development. Pediatr Nephrol. 2000;15:192–195
  15. Celsi G, Kistner A, Aizman R, et al. Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring. Pediatr Res. 1998;44:317–322
  16. Hinchliffe SA, Lynch MR, Sargent PH, Howard CV, van Velzen D. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol. 1992;99:296–301
  17. Manalich R, Reyes L, Herrera M, Melendi C, Fundora I. Relationship between weight at birth and the number and size of renal glomeruli in humans: A histomorphometric study. Kidney Int. 2000;58:770–773
  18. Zidar N, Cor A, Premru Srsen T, Stajer D. Is there an association between glomerular density and birth weight in healthy humans. Nephron. 1998;80:97–98
  19. Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med. 2003;348:101–108
  20. Verburg BO, Geelhoed JJ, Steegers EA, et al. Fetal kidney volume and its association with growth and blood flow in fetal life: The Generation R Study. Kidney Int. 2007;72:754–761
  21. Jaddoe VW, Mackenbach JP, Moll HA, et al. The Generation R Study: Design and cohort profile. Eur J Epidemiol. 2006;21:475–484
  22. Jaddoe VW, Bakker R, van Duijn CM, et al. The Generation R Study Biobank: A resource for epidemiological studies in children and their parents. Eur J Epidemiol. 2007;22:917–923
  23. Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. STROBE initiative: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet. 2007;370:1453–1457
  24. Verburg BO, Steegers EAP, de Ridder MAJ, et al. New charts for ultrasound dating of pregnancy and assessment of fetal growth, longitudinal data from a population-based cohort study. Ultrasound Obstet Gynecol. 2008;31:388–396
  25. Hadlock FP, Deter RL, Harrist RB, Park SK. Fetal abdominal circumference as a predictor of menstrual age. AJR Am J Roentgenol. 1982;139:367–370
  26. Hadlock FP, Harrist RB, Deter RL, Park SK. Fetal femur length as a predictor of menstrual age: Sonographically measured. AJR Am J Roentgenol. 1982;138:875–878
  27. Shepard M, Filly RA. A standardized plane for biparietal diameter measurement. J Ultrasound Med. 1982;1:145–150
  28. Hadlock FP, Harrist RB, Carpenter RJ, Deter RL, Park SK. Sonographic estimation of fetal weight (The value of femur length in addition to head and abdomen measurements). Radiology. 1984;150:535–540
  29. Baschat AA, Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol. 2004;28:67–80
  30. van den Wijngaard JA, Groenenberg IA, Wladimiroff JW, Hop WC. Cerebral Doppler ultrasound of the human fetus. Br J Obstet Gynaecol. 1989;96:845–849
  31. Wladimiroff JW, van den Wijngaard JA, Degani S, et al. Cerebral and umbilical arterial blood flow velocity waveforms in normal and growth-retarded pregnancies. Obstet Gynaecol. 1987;69:705–709
  32. Jeanty P, Dramaix-Wilmet M, Elkhazen N, Hubinont C, van Regemorter N. Measurements of fetal kidney growth on ultrasound. Radiology. 1982;144:159–162
  33. Gupta AK, Anand NK, Lamba IM. Ultrasound evaluation of kidney dimensions in neonates. Indian Pediatr. 1993;30:319–324
  34. Konje JC, Okaro CL, Bell SC, de Chazal R, Taylor DJ. A cross-sectional study of changes in fetal renal size with gestation in appropriate- and small-for-gestational-age fetuses. Ultrasound Obstet Gynecol. 1997;10:22–26
  35. Schmidt IM, Chellakooty M, Boisen KA, et al. Impaired kidney growth in low-birth-weight children: Distinct effects of maturity and weight for gestational age. Kidney Int. 2005;68:731–740
  36. Verburg BO, Mulder PG, Hofman A, Jaddoe VW, Witteman JC, Steegers EA. Intra- and interobserver reproducibility study of early fetal growth parameters. Prenat Diagn. 2008;28:323–331
  37. Vohr BR, McGarvey ST, Tucker R. Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age. Diabetes Care. 1999;22:284–1291
  38. Schreuder MF, Nauta J. Prenatal programming of nephron number and blood pressure. Kidney Int. 2007;72:265–268
  39. Hotoura E, Argyropoulou M, Papadopoulou F, et al. Kidney development in the first year of life in small-for-gestational-age preterm infants. Pediatr Radiol. 2005;35:991–994
  40. Giapros V, Drougia A, Hotoura E, Papadopoulou F, Argyropoulou M, Andronikou S. Kidney growth in small-for-gestational-age infants: Evidence of early accelerated renal growth. Nephrol Dial Transplant. 2006;21:3422–3427
  41. Pinto-Sietsma SJ, Janssen WM, Hillege HL, Navis G, de Zeeuw D, de Jong PE. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol. 2000;11:1882–1888
  42. van Hooft IM, Grobbee DE, Derkx FH, de Leeuw PW, Schalekamp MA, Hofman A. Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents. N Engl J Med. 1991;324:1305–1311
  43. Konje JC, Bell SC, Morton JJ, de Chazal R, Taylor DJ. Human fetal kidney morphometry during gestation and the relationship between weight, kidney morphometry and plasma active renin concentration at birth. Clin Sci (Lond). 1996;91:169–175

 Originally published online as doi:10.1053/j.ajkd.2008.07.030 on October 13, 2008.

PII: S0272-6386(08)01228-6

doi: 10.1053/j.ajkd.2008.07.030

American Journal of Kidney Diseases
Volume 53, Issue 2 , Pages 248-258 , February 2009

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