American Journal of Kidney Diseases
Volume 53, Issue 4 , Pages 658-664 , April 2009

Effects of Nocturnal Hemodialysis on Melatonin Rhythm and Sleep-Wake Behavior: An Uncontrolled Trial

  • Birgit C.P. Koch, PharmD

      Affiliations

    • Department of Clinical Pharmacy, Meander Medical Center, Amersfoort, The Netherlands
    • Corresponding Author InformationAddress correspondence to Birgit C.P. Koch, PharmD, Meander Medical Center, Department of Clinical Pharmacy, Postal Box 1502/Utrechtseweg 160, 3800 BM Amersfoort, The Netherlands
  • ,
  • E. Christiaan Hagen, MD, PhD

      Affiliations

    • Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands
  • ,
  • J. Elsbeth Nagtegaal, PharmD, PhD

      Affiliations

    • Department of Clinical Pharmacy, Meander Medical Center, Amersfoort, The Netherlands
  • ,
  • Jan B.S. Boringa, MD

      Affiliations

    • Department of Neurology, Meander Medical Center, Amersfoort, The Netherlands
  • ,
  • Gerard A. Kerkhof, PhD

      Affiliations

    • Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    • Center for Sleep Wake Disorders, Medical Center Haaglanden, the Hague, The Netherlands
  • ,
  • Piet M. Ter Wee, MD, PhD

      Affiliations

    • Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

Received 15 April 2008 ,Accepted 1 August 2008.

References 

  1. Parker KP. Sleep disturbances in dialysis patients. Sleep Med Rev. 2003;7:131–143
  2. Parker KP, Bliwise DL, Rye DB. Hemodialysis disrupts basic sleep regulatory mechanisms: Building hypotheses. Nurs Res. 2000;49:327–332
  3. Nagtegaal E, Peeters T, Swart W, Smits M, Kerkhof G, van der Meer G. Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome. Ther Drug Monit. 1998;20:181–183
  4. Akerstedt T, Fröberg JA, Friberg Y, Wetterberg L. Melatonin excretion, body temperature and subjective arousal during 64 hours of sleep deprivation. Psychoneuroendocrinology. 1979;4:219–225
  5. Tzischinsky O, Shlitner A, Lavie P. The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulfametoxymelatonin. J Biol Rhythms. 1993;8:199–209
  6. Karasek M, Szuflet A, Chrzanowski W, Zylinska K, Swietoslawski J. Decreased melatonin nocturnal concentrations in hemodialyzed patients. Neuro Endocrinol Lett. 2005;26:653–656
  7. Vaziri ND, Oveisi F, Wierszbiezki M, Shaw V, Sporty LD. Serum melatonin and 6-sulfatoxymelatonin in end-stage renal disease: Effect of hemodialysis. Artif Organs. 1993;17:764–769
  8. Gotch F. The current place of urea kinetic modeling with respect to different dialysis modalities. Nephrol Dial Transplant. 1998;13:10–14
  9. Sweere Y, Kerkhof GA, De Weerd AW, Kamphuisen HA, Kemp B, Schimsheimer RJ. The validity of the Dutch Sleep Disorders Questionnaire (SDQ). J Psychosom Res. 1998;45:549–555
  10. Carskadon MA, Rechtschaffen A. Monitoring and staging human sleep. In:  Kryger MH,  Roth T,  Dement WC editor. Principles and Practice of Sleep Medicine. (ed 4). Philadelphia, PA: Elsevier-Saunders; 2005;p. 1359–1377
  11. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington DC: US Government Printing Office, National Institutes of Health; 1968;
  12. Renine: Databank Registration Kidney Replacement Therapy in The Netherlands, Data 2005. www.renine.nlAccessed January 10, 2007
  13. Hirshkowitz M. Normal human sleep: An overview. Med Clin North Am. 2004;88:551–565
  14. Kushida CA, Littner MR, Morgenthaler T, et al. Practice parameters for the indications for polysomnography and related procedures: An update for 2005. Sleep. 2005;28:499–521
  15. Siegel JM. REM sleep. In:  Kryger MH,  Roth T,  Dement WC editor. Principles and Practice of Sleep Medicine. (ed 4). Philadelphia, PA: Elsevier-Saunders; 2005;p. 120–135
  16. Pierratos A. Nocturnal home haemodialysis: An update on a 5-year experience. Nephrol Dial Transplant. 1999;14:2835–2840
  17. Walsh M, Culleton B, Tonelli M, Manns B. A systematic review on the effect of nocturnal hemodialysis on blood pressure, left ventricular hypertrophy, anemia, mineral metabolism, and health-related quality of life. Kidney Int. 2005;67:1500–1507
  18. Hanly PJ, Gabor JY, Chan C, Pierratos A. Daytime sleepiness in patients with CRF: Impact of nocturnal hemodialysis. Am J Kidney Dis. 2003;41:403–410
  19. Hanly P, Chan C, Pierratos A. The impact of nocturnal hemodialysis on sleep apnea in ESRD patients. Nephrol News Issues. 2003;17:19–21
  20. Hanly PJ, Pierratos A. Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis. N Engl J Med. 2001;344:102–107
  21. Czeisler CA, Buxton OM, Singh Khalsa SB. The human circadian timing system and sleep-wake regulation. In:  Kryger MH,  Roth T,  Dement WC editor. Principles and Practice of Sleep Medicine. (ed 4). Philadelphia, PA: Elsevier-Saunders; 2005;p. 375–394
  22. Viljoen M, Steyn ME, van Rensburg BWJ, Reinach SG. Melatonin in chronic renal failure. Nephron. 1992;60:138–143
  23. Holmes EW, Hojvat SA, Kahn SE, Bermes EW. Testicular dysfunction in experimental chronic renal insufficiency: A deficiency of nocturnal pineal N-acetyltransferase activity. Br J Exp Pathol. 1989;70:349–356
  24. Ferchland A, Rettkowski O, Pönicke K, Deuber HJ, Ostens B, Brodde OE. Effects of uremic plasma on alpha- and beta-adrenoceptors subtypes. Nephron. 1998;80:46–50
  25. Geron R, Shurtz-Swirski R, Sela S, et al. Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis—Is melatonin a player?. Nephrol Dial Transplant. 2006;21:3196–3201
  26. Scheer FAJL, Montfrans van GA, Someren van EJW, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004;43:192–197
  27. Jonas M, Garfinkel D, Zisapel N, Laudon M, Grossman E. Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. Blood Pressure. 2002;12:19–24
  28. Simko F, Paulis L. Melatonin as a potential antihypertensive treatment. J Pineal Res. 2007;42:319–322
  29. Lüdemann P, Zwernemann S, Lerchl A. Clearance of melatonin and 6-sulfatoxymelatonin by hemodialysis in patients with end-stage renal disease. J Pineal Res. 2001;3:222–227
  30. Koch BCP, Nagtegaal JE, Hagen EC, et al: Subjective sleep efficiency of haemodialysis patients. Clin Nephrol (in press)

 Originally published online as doi:10.1053/j.ajkd.2008.08.006 on October 28, 2008.

 Trial registration: www.clinicaltrials.gov; study number: NCT004044456.

PII: S0272-6386(08)01244-4

doi: 10.1053/j.ajkd.2008.08.006

American Journal of Kidney Diseases
Volume 53, Issue 4 , Pages 658-664 , April 2009