Acute Kidney Failure in the Third Trimester of Pregnancy

Photomicrographs of the kidney biopsy specimen. (A) Glomeruli show diffuse hypercellularity with interstitial edema and inflammation (hematoxylin and eosin; original magnification ×200). (B) Glomerulus with diffuse endocapillary proliferation, leukocyte infiltration, and small segmental cellular crescent (Jones methenamine silver; original magnification ×400). (C) Two glomeruli with granular loop deposits of immunoglobulin G (IgG; fluorescein conjugated antihuman IgG; original magnification ×200). (D) Glomerulus with granular loop deposits of C3 (fluorescein conjugated antihuman C3; original magnification ×400). Transmission electron photomicrographs show (E) a glomerulus with numerous subepithelial hump-like deposits (arrow) (unstained; original magnification ×12,000) and (F) a glomerular basement membrane with 2 subepithelial hump-like deposits (arrow) (unstained; original magnification ×20,000).