American Journal of Kidney Diseases
Volume 53, Issue 1 , Pages 5-8 , January 2009

IgA Nephropathy: A Disease in Search of a Large-Scale Clinical Trial to Reliably Inform Practice

  • Giovanni F.M. Strippoli, MD, PhD, MPH (Hons), MM (Epi)

      Affiliations

    • Mario Negri Sud Consortium, Chieti, Italy
    • Diaverum Medical-Scientific Office, Lund, Sweden
    • Cochrane Renal Group, Sydney, Australia
    • University of Sydney, Sydney, Australia
    • Corresponding Author InformationAddress correspondence to Giovanni F. M. Strippoli, NHMRC Centre for Clinical Research Excellence in Renal Medicine, Cochrane Renal Group, University of Sydney, Australia
    • ,
  • Ausilia Maione, MSc PharmChem

      Affiliations

    • Mario Negri Sud Consortium, Chieti, Italy
    • ,
  • Francesco P. Schena, MD

      Affiliations

    • University of Bari, Italy, Bari, Italy
    • ,
  • G. Tognoni, MD

      Affiliations

    • Mario Negri Sud Consortium, Chieti, Italy
    • ,
  • Jonathan C. Craig, MD, PhD, MM (Clin Epi)

      Affiliations

    • Cochrane Renal Group, Sydney, Australia
    • University of Sydney, Sydney, Australia

References 

  1. D'Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med. 1987;64:709–727
  2. Rekola S, Bergstrand A, Bucht H. Deterioration of GFR in IgA nephropathy as measured by 51Cr-EDTA clearance. Kidney Int. 1991;49:1050–1054
  3. Gallo GR, Katafuchi R, Neelakantappa K, et al. Prognostic pathologic markers in IgA nephropathy. Am J Kidney Dis. 1988;12:363–365
  4. Rostoker G, Desvaux-Belghiti D, Pilatte Y, et al. Immunomodulation with low-dose immunoglobulins for moderate IgA nephropathy and Henoch-Schonlein purpura (Preliminary results of a prospective uncontrolled trial). Nephron. 1995;69:327–334
  5. Neelakantappa K, Gallo GR, Baldwin DS. Proteinuria in IgA nephropathy. Kidney Int. 1988;33:716–721
  6. Manno C, Strippoli GF, D'Altri C, et al. A novel simpler histological classification for renal serviva in IgA nephropathy: a retrospective study. Am J Kidney Dis. 2007;49:763–775
  7. Lv J, Zhang H, Chen Y, et al. Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial. Am J Kidney Dis. 2009;53:26–32
  8. Samuels JA, Strippoli GF, Craig JC, et al. Immunosuppressive agents for treating IgA nephropathy. Cochrane Database Syst Rev. 2003;4:CD003965
  9. Strippoli GF, Craig JC, Schena FP. The number, quality and coverage of randomized controlled trials in nephrology. J Am Soc Nephrol. 2004;15:411–419
  10. Strippoli GFM, Manno C, Schena FP. An ‘evidence-based' survey of therapeutic options for IgA nephropathy: assessment and criticism. Am J Kidney Dis. 2003;41:1129–1139
  11. Ioannidis JP, Gwinn M, Little J, et al. A road map for efficient and reliable human genome epidemiology. Nat Genet. 2008;38:3–5
  12. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia). Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet. 1997;349:1857–1863
  13. Ruggenenti P, Perna A, Gherardi G, et al. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN) Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Lancet. 1998;352:1252–1256
  14. Trotta F, Apolone G, Garattini S, et al. Stopping a trial early in oncology: for patients or for industry?. Ann Oncol. 2008;19:1347–1353
  15. Strippoli GF, Craig JC. Hypothesis versus association: the optimal hemoglobin target debate. Am J Kidney Dis. 2005;46:970–973
  16. ONTARGET Investigators. Telmisartan, ramilpril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547–1559
  17. NAPRTCS (North American Pediatric Renal Trials and Collaborative Studies). http://spitfire.emmes.com/study/ped/index.htmAccessed Sept 15, 2008

PII: S0272-6386(08)01563-1

doi: 10.1053/j.ajkd.2008.10.035

American Journal of Kidney Diseases
Volume 53, Issue 1 , Pages 5-8 , January 2009

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