American Journal of Kidney Diseases
Volume 53, Issue 3 , Pages 448-456 , March 2009

Association Between Oral Sodium Phosphate Bowel Preparations and Kidney Injury: A Systematic Review and Meta-analysis

  • Steven M. Brunelli, MD, MSCE

      Affiliations

    • Corresponding Author InformationAddress correspondence to Steven M. Brunelli, MD, MSCE, 75 Francis St, MRB-4, Boston, MA 20115

Received 10 July 2008 ,Accepted 16 September 2008.

References 

  1. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41:1–12
  2. US Renal Data System. 1999 USRDS Annual Data Report. http://www.usrds.orgAccessed March 24, 2008
  3. Seeff LC, Richards T, Shapior JA, et al. How many endoscopies are performed for colorectal cancer screening? (Results from CDC's survey of endoscopic capacity). Gastroenterology. 2004;127:1670–1677
  4. Orias M, Mahnensmith RL, Perazalla MA. Extreme hyperphosphatemia and acute renal failure after a phosphorus-containing bowel regimen. Am J Nephrol. 1999;19:60–63
  5. Ullah N, Yeh R, Ehrinpreis M. Fatal hyperphosphatemia from a phosphosoda bowel preparation. J Clin Gastroenterol. 2002;34:457–458
  6. Fine A, Patterson J. Severe hyperphosphatemia following phosphate administration for bowel preparation in patients with renal failure: Two cases and review of the literature. Am J Kidney Dis. 1997;29:103–105
  7. Carl DE, Sica DA. Acute phosphate nephropathy following colonoscopy preparation. Am J Med Sci. 2007;334:151–154
  8. Markowitz GS, Stokes MB, Radhakrishnan J, D'Agait VD. Acute phosphate nephropathy following oral sodium phosphate bowel purgative: An underrecognized cause of chronic renal failure. J Am Soc Nephrol. 2005;16:3389–3396
  9. Chan A, Depew W, Vanner S. Use of oral sodium phosphate colonic lavage solution by Canadian colonoscopists: Pitfalls and complications. Can J Gastroenterol. 1997;11:334–338
  10. Beyea A, Blovk C, Schned A. Acute phosphate nephropathy following oral sodium phosphate solution to cleanse the bowel for colonoscopy. Am J Kidney Dis. 2007;50:151–154
  11. Markowitz GS, Nasr SH, Klein P, et al. Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing. Hum Pathol. 2004;35:675–684
  12. Abaskharoun R, Depew W, Vanner S. Changes in renal function following administration of oral sodium phosphate or polyethylene glycol for colon cleansing before colonoscopy. Can J Gastroenterol. 2007;21:227–231
  13. Brunelli SM, Lewis JD, Gupta M, Latif SM, Weiner MG, Feldman HI. Risk of kidney injury following oral phosphosoda bowel preparations. J Am Soc Nephrol. 2007;18:3199–3205
  14. Hurst FP, Bohen EM, Osgard EM, et al. Association of oral sodium phosphate purgative use with acute kidney injury. J Am Soc Nephrol. 2007;18:3192–3198
  15. Johanson JF, Popp JW, Cohen LB, et al. A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansing. Am J Gastroenterol. 2007;102:2238–2246
  16. Khurana A, McLean L, Atkinson S, Foulkes CJ. The effect of oral sodium phosphate drug products on renal function in adults undergoing bowel endoscopy. Arch Intern Med. 2008;168:593–597
  17. Russmann S, Lamerato L, Marfatia A, et al. Risk of impaired renal function after colonoscopy: A cohort study in patients receiving either oral sodium phosphate or polyethylene glycol. Am J Gastroenterol. 2007;102:2655–2663
  18. Singal AK, Rosman AS, Post JB, Bauman WA, Spungen AM, Korsten MA. The renal safety of bowel preparations for colonoscopy: A comparative study of oral sodium phosphate solution and polyethylene glycol. Aliment Pharmacol Ther. 2008;27:41–47
  19. Korsten MA, Rosman A, Shaw S, et al. Bowel cleansing prior to colonoscopy (C): Evidence for renal toxicity in a randomized, prospective trial using oral sodium phosphate (OSP) and polyethylene glycol (PEG). Gastrointest Endosc. 2007;65:AB103;(abstr)
  20. Curtin F, Elbourne D, Altman DG. Meta-analysis combining parallel and cross-over clinical trials (II: Binary outcomes). Stat Med. 2002;21:2145–2159
  21. Suissa S. Binary methods for continuous outcomes: A parametric alternative. J Clin Epidemiol. 1991;44:241–248
  22. Whitehead A, Bailey AJ, Elbourne D. Combining summaries of binary outcomes with those of continuous outcomes in a meta-analysis. J Biopharm Stat. 1999;9:1–16
  23. Hsu CW, Imperial TF. Meta-analysis and cost comparison of polyethylene glycol lavage vs. sodium phosphate for colonoscopy preparation. Gastrointest Endosc. 1998;48:276–282
  24. Tan JJ, Tjandra JJ. Which is the optimal bowel preparation for colonoscopy—A meta-analysis. Colorectal Dis. 2006;8:247–258
  25. Belsey J, Epstein O, Heresbach D. Systematic review: Oral bowel preparation for colonoscopy. Aliment Pharmacol Ther. 2007;25:373–384
  26. Habr-Gama A, Bringel RW, Nahas SC, et al. Bowel preparation for colonoscopy: Comparison of mannitol and sodium phosphate (Results of a prospective randomized study). Rev Hosp Clin Fac Med Sao Paulo. 1999;54:187–192
  27. DiPalma JA, Buckley SE, Warner BA, Culpepper RM. Biochemical effects of oral sodium phosphate. Dig Dis Sci. 1996;41:749–753
  28. Lieberman DA, Ghormlet J, Flora K. Effects of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine. Gastrointest Endosc. 1996;43:467–469
  29. Zager R. Hyperphosphatemia: A factor that provokes severe experimental acute renal failure. J Clin Lab Med. 1982;53:2425–2429
  30. Ibels LS, Alfrey AC, Haut L, Huffer WE. Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med. 1978;298:122–126
  31. Karlinsky ML, Haut L, Buddington B, Schrier NA, Alfrey AC. Preservation of renal function in experimental glomerulonephritis. Kidney Int. 1980;17:293–302
  32. Cozzolino M, Dusso AS, Liapis H, et al. The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats. J Am Soc Nephrol. 2002;13:2299–2308
  33. Nagano N, Miyata S, Obana S, et al. Sevelamer hydrochloride, a phosphate binder, protects against deterioration of renal function in rats with progressive chronic renal insufficiency. Nephrol Dial Transplant. 2003;18:2014–2023
  34. Wexner SD, Beck DE, Baron TH, et al. Prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Gastrointest Endosc. 2006;63:894–909
  35. Brady CE, DiPalma JA, Morawski SG, Santa Ana CA, Fordtran JS. Urinary excretion of polyethylene glycol 3350 and sulfate after gut lavage with a polyethylene glycol electrolyte lavage solution. Gastroenterology. 1986;90:1914–1918
  36. Smyth HF, Carpenter CP, Weil OS. The toxicity of polyethylene glycols. J Am Pharm Assoc. 1950;39:349–354
  37. Jones JD, Burnett PC. Implication of creatinine and gut flora in the uremic syndrome: Induction of “creatininase” in colon contents of the rat by dietary creatinine. Clin Chem. 1972;18:280–284
  38. Dubos R, Miller BF. The production of bacterial enzymes capable of decomposing creatinine. J Biol Chem. 1937;121:429–445
  39. Van Eyk HG, Vermaat RJ, Leijnse-Ybema HJ, Leijnse B. The conversion of creatinine by creatininase of bacterial origin. Enzymologia. 1968;34:198–202

 Originally published online as doi:10.1053/j.ajkd.2008.09.022 on December 22, 2008.

PII: S0272-6386(08)01574-6

doi: 10.1053/j.ajkd.2008.09.022

American Journal of Kidney Diseases
Volume 53, Issue 3 , Pages 448-456 , March 2009

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