American Journal of Kidney Diseases
Volume 54, Issue 1 , Pages 112-121 , July 2009

Decreased Antibody Response to Influenza Vaccination in Kidney Transplant Recipients: A Prospective Cohort Study

  • Kelly A. Birdwell, MD, MSCI

      Affiliations

    • Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Mine R. Ikizler, MS

      Affiliations

    • Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Edith C. Sannella, MT

      Affiliations

    • Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Li Wang, MS

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Daniel W. Byrne, MS

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • T. Alp Ikizler, MD

      Affiliations

    • Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Peter F. Wright, MD

      Affiliations

    • Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN
    • Division of Infectious Disease and International Health, Dartmouth Medical School, Lebanon, NH
    • Corresponding Author InformationAddress correspondence to Peter F. Wright, MD, Dartmouth Medical School, Division of Infectious Disease and International Health, 1 Medical Center Dr, Lebanon, NH 03756

Received 12 June 2008 ,Accepted 30 September 2008.

  • Image Result

    Study enrollment and follow up.

    Study enrollment and follow up.

  • Image Result

    Serological response to the 2006-2007 inactivated influenza vaccine expressed as geometric mean titers. For the control group: A/H1N1 prevaccination (pre), 33.6, postvaccination (post), 108.9; A/H3N2

    Serological response to the 2006-2007 inactivated influenza vaccine expressed as geometric mean titers. For the control group: A/H1N1 prevaccination (pre), 33.6, postvaccination (post), 108.9; A/H3N2 pre, 36.7, post, 180.4; B pre, 36.1, post, 130.1. For the transplant recipient group, A/H1N1 pre, 34.2, post, 53.2; A/H3N2 pre, 23.8, post, 55.7; B pre, 40, post, 80.2.

  • Image Result
    Odds ratios (95% confidence intervals) for the primary outcome of seroresponse (4-fold increase in antibody titer).

    Odds ratios (95% confidence intervals) for the primary outcome of seroresponse (4-fold increase in antibody titer).

  • Image Result
    Odds ratios (95% confidence intervals) for the primary outcome of seroprotection (antibody titer ≥ 1:32).

    Odds ratios (95% confidence intervals) for the primary outcome of seroprotection (antibody titer ≥ 1:32).

 Originally published online as doi: 10.1053/j.ajkd.2008.09.023 on January 30, 2009.

PII: S0272-6386(08)01608-9

doi: 10.1053/j.ajkd.2008.09.023

American Journal of Kidney Diseases
Volume 54, Issue 1 , Pages 112-121 , July 2009

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