American Journal of Kidney Diseases
Volume 54, Issue 1 , Pages 77-85 , July 2009

Immunogenicity of a Standard Trivalent Influenza Vaccine in Patients on Long-term Hemodialysis: An Open-Label Trial

  • Johan Scharpé, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • Willy E. Peetermans, MD, PhD

      Affiliations

    • Division of Infectious Diseases, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • Johan Vanwalleghem, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Virga Jesse Hospital Hasselt, Belgium
  • ,
  • Bart Maes, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • Bert Bammens, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • Kathleen Claes, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • André D. Osterhaus, MD, PhD

      Affiliations

    • Department of Virology, Erasmus MC, Rotterdam, The Netherlands
  • ,
  • Yves Vanrenterghem, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  • ,
  • Pieter Evenepoel, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    • Corresponding Author InformationAddress correspondence to Pieter Evenepoel, MD, PhD, Dienst Nefrologie, Universitair Ziekenhuis Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium

Received 8 August 2008 ,Accepted 20 November 2008.

References 

  1. Girndt M, Sester M, Sester U, et al. Molecular aspects of T- and B-cell function in uremia. Kidney Int. 2001;78:206–211
  2. Bhandari S, Farr M, Sellars L. Influenza vaccination in renal patients. Nephrol Dial Transplant. 1995;10:912–913
  3. Gilbertson DT, Unruh M, Mcbean AM, et al. Influenza vaccine delivery and effectiveness in end-stage renal disease. Kidney Int. 2003;63:738–743
  4. Tokars JI, Finelli L, Alter MJ, et al. National surveillance of dialysis-associated diseases in the United States, 2001. Semin Dial. 2004;17:310–319
  5. Rangel MC, Coronado VG, Euler GL, et al. Vaccine recommendations for patients on chronic dialysis (The Advisory Committee on Immunization Practices and the American Academy of Pediatrics). Semin Dial. 2000;13:101–107
  6. Osanloo EO, Berlin BS, Popli S. Antibody responses to influenza vaccination in patients with chronic renal failure. Kidney Int. 1978;14:614–618
  7. Song JY, Cheong HJ, Ha SH, et al. Active influenza immunization in hemodialysis patients: Comparison between single-dose and booster vaccination. Am J Nephrol. 2006;26:206–211
  8. Antonen JA, Hannula PM, Pyhala R, et al. Adequate seroresponse to influenza vaccination in dialysis patients. Nephron. 2000;86:56–61
  9. Cappel R, Van Beers D, Liensnard C. Impaired humoral and cell-mediated immune responses in dialyzed patients after influenza vaccination. Nephron. 1983;33:21–25
  10. Vogtlander NPJ, Brown A, Valentijn RM, et al. Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients. Vaccine. 2004;22:2199–2201
  11. Versluis DJ, Beyer WE. Intact humoral immune response in patients on continuous ambulatory peritoneal dialysis. Nephron. 1988;49:16–19
  12. Versluis DJ, Beyer WE, Masurel N, et al. Value of booster immunisation with influenza vaccine in patients undergoing haemodialysis. Br Med J. 1987;294–348
  13. Tanzi E, Amendola A, Pariani E, et al. Lack of effect of a booster dose of influenza vaccine in hemodialysis patients. J Med Virol. 2007;79:1176–1179
  14. Rautenberg P, Proppe D, Schütte A, et al. Influenza subtype-specific immunoglobulin A and G responses after booster versus one double-dose vaccination in hemodialysis patients. Eur J Clin Microbiol Infect Dis. 1989;8:897–900
  15. Bouillon R, Coopmans W, Degroote DE, et al. Immunoradiometric assay of parathyrin with polyclonal and monoclonal region-specific antibodies. Clin Chem. 1990;36:271–276
  16. Souberbielle JC, Boutten A, Carlier MC, et al. Inter-method variability in PTH measurement: Implication for the care of CKD patients. Kidney Int. 2006;70:345–350
  17. de Loor H, Bammens B, Evenepoel P, et al. Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. Clin Chem. 2005;51:1535–1538
  18. Beyer WEP, Palache AM, Luchters G, et al. Seroprotection rate, mean fold increase, seroconversion rate: Which parameter adequately expresses seroresponse to influenza vaccination?. Virus Res. 2004;103:125–132
  19. Eleftheriadis T, Antoniadi G, Liakopoulos V, et al. Disturbances of acquired immunity in hemodialysis patients. Semin Dial. 2007;20:440–451
  20. Fernandez E, Betriu MA, Gomez R, et al. Response to the hepatitis B virus vaccine in haemodialysis patients: Influence of malnutrition and its importance as a risk factor for morbidity and mortality. Nephrol Dial Transplant. 1996;11:1559–1563
  21. Peces R, de la Torre M, Alcazar R, et al. Prospective analysis of the factors influencing the antibody response to hepatitis B vaccine in hemodialysis patients. Am J Kidney Dis. 1997;29:239–245
  22. Sezer S, Özdemir FN, Güz G, et al. Factors influencing response to hepatitis B virus vaccination in hemodialysis patients. Transplant Proc. 2000;32:607–608
  23. Kara IH, Yilmaz ME, Suner A, et al. The evaluation of immune responses that occur after HBV infection and HBV vaccination in hemodialysis patients. Vaccine. 2004;22:3963–3967
  24. Dacko C, Holley JL. The influence of nutritional status, dialysis adequacy, and residual renal function on the response to hepatitis B vaccination in peritoneal dialysis patients. Adv Perit Dial. 1996;12:315–317
  25. Hassan K, Shternberg L, Alhaj M, et al. The effect of erythropoietin therapy and hemoglobin levels on the immune response to Engerix-B vaccination in chronic kidney disease. Ren Fail. 2003;25:471–478
  26. Elwell RJ, Neumann M, Bailie GR. Factors associated with long-term antibody production induced by hepatitis B vaccine in patients undergoing hemodialysis: A retrospective cohort study. Pharmacotherapy. 2003;23:1558–1563
  27. Krüger S, Müller-Steinhardt M, Kirchner H, et al. A 5-year follow-up on antibody response after diphtheria and tetanus vaccination in hemodialysis patients. Am J Kidney Dis. 2001;38:1264–1270
  28. Brydak LB, Roszkowska-Blaim M, Machala M, et al. Immunological response to influenza vaccination in children with renal failure. Nephrol Dial Transplant. 2001;16:643–644
  29. Chiew Tong NK, Beran J, Kee SA, et al. Immunogenicity and safety of an adjuvanted hepatitis B vaccine in pre-hemodialysis and hemodialysis patients. Kidney Int. 2005;68:2298–2303
  30. Hobson D, Baker FA, Curry RL. Effect of influenza vaccines in stimulating antibody in volunteers with prior immunity. Lancet. 1973;2:155–156
  31. Blumberg EA, Albano C, Pruett T, et al. The immunogenicity of influenza virus vaccine in solid organ transplant recipients. Clin Infect Dis. 1996;22:295–302
  32. Scharpé J, Evenepoel P, Maes B, et al. Influenza vaccination is efficacious and safe in renal transplant recipients. Am J Transplant. 2008;8:332–337
  33. Ahluwalia N, Sun J, Krause D, et al. Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr. 2004;79:516–521
  34. Fulop T, Wagner JR, Khalil A, et al. Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. J Gerontol A Biol Sci Med Sci. 1999;54:59–64
  35. Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987;46:329–334
  36. Beyer WE, Versluis DJ, Kramer P, et al. Trivalent influenza vaccine in patients on haemodialysis: Impaired seroresponse with differences for A-H3N2 and A-H1N1 vaccine components. Vaccine. 1987;5:43–48
  37. Kovacic V, Sain M, Vukman V. Efficient haemodialysis improves the response to hepatitis B virus vaccination. Intervirology. 2002;45:172–176
  38. Antonen JA, Pyhala R, Hannula PM, et al. Influenza vaccination of dialysis patients: cross-reactivity of induced haemagglutination-inhibiting antibodies to H3N2 subtype antigenic variants is comparable with the response of naturally infected young healthy adults. Nephrol Dial Transplant. 2003;18:777–781
  39. Kreft B, Fischer A, Kruger S, et al. The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency. Biogerontology. 2000;1:61–66
  40. Cavdar C, Sayan M, Sifil A, et al. The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients. Scand J Urol Nephrol. 2003;37:71–76

 Originally published online as doi: 10.1053/j.ajkd.2008.11.032 on April 2, 2009.

 Trial registration: www.clinicaltrials.gov; study number: NCT00776750.

PII: S0272-6386(09)00049-3

doi: 10.1053/j.ajkd.2008.11.032

American Journal of Kidney Diseases
Volume 54, Issue 1 , Pages 77-85 , July 2009