American Journal of Kidney Diseases
Volume 53, Issue 6 , Pages 961-973 , June 2009

Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

  • Steven G. Coca, DO

      Affiliations

    • Section of Nephrology, Yale University, West Haven, CT
    • Veterans Affairs Medical Center, West Haven, CT
    • ,
  • Bushra Yusuf, MD

      Affiliations

    • Section of Nephrology, Yale University, West Haven, CT
    • Veterans Affairs Medical Center, West Haven, CT
    • ,
  • Michael G. Shlipak, MD, MPH

      Affiliations

    • San Francisco Veterans Affairs Medical Center, San Francisco, CA
    • University of California, San Francisco, CA
    • ,
  • Amit X. Garg, MD, PhD

      Affiliations

    • University of Western Ontario, London, Ontaria, Canada
    • ,
  • Chirag R. Parikh, MD, PhD

      Affiliations

    • Section of Nephrology, Yale University, West Haven, CT
    • Veterans Affairs Medical Center, West Haven, CT
    • Corresponding Author InformationAddress correspondence to Chirag Parikh, MD, PhD, Section of Nephrology, Yale University and VAMC, 950 Campbell Ave, Mail Code 151B, Bldg 35 A, Rm 219, West Haven, CT 06516

Received 18 September 2008 ,Accepted 28 November 2008.

References 

  1. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365–3370
  2. Hsu CY, McCulloch CE, Fan D, Ordonez JD, Chertow GM, Go AS. Community-based incidence of acute renal failure. Kidney Int. 2007;72:208–212
  3. Waikar SS, Curhan GC, Wald R, McCarthy EP, Chertow GM. Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol. 2006;17:1143–1150
  4. de Mendonca A, Vincent JL, Suter PM, et al. Acute renal failure in the ICU: Risk factors and outcome evaluated by the SOFA score. Intensive Care Med. 2000;26:915–921
  5. Forman DE, Butler J, Wang Y, et al. Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure. J Am Coll Cardiol. 2004;43:61–67
  6. Groeneveld AB, Tran DD, van der Meulen J, Nauta JJ, Thijs LG. Acute renal failure in the medical intensive care unit: Predisposing, complicating factors and outcome. Nephron. 1991;59:602–610
  7. Hoste EA, Lameire NH, Vanholder RC, Benoit DD, Decruyenaere JM, Colardyn FA. Acute renal failure in patients with sepsis in a surgical ICU: Predictive factors, incidence, comorbidity, and outcome. J Am Soc Nephrol. 2003;14:1022–1030
  8. Lassnigg A, Schmidlin D, Mouhieddine M, et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study. J Am Soc Nephrol. 2004;15:1597–1605
  9. Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT. Renal dysfunction after myocardial revascularization: Risk factors, adverse outcomes, and hospital resource utilization (The Multicenter Study of Perioperative Ischemia Research Group). Ann Intern Med. 1998;128:194–203
  10. Thakar CV, Worley S, Arrigain S, Yared JP, Paganini EP. Influence of renal dysfunction on mortality after cardiac surgery: Modifying effect of preoperative renal function. Kidney Int. 2005;67:1112–1119
  11. Basile DP, Donohoe D, Roethe K, Osborn JL. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol. 2001;281:F887–F899
  12. Basile DP. Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive nephropathy. Curr Opin Nephrol Hypertens. 2004;13:1–7
  13. Burne-Taney MJ, Liu M, Ascon D, Molls RR, Racusen L, Rabb H. Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: A possible mechanism linking early injury and progressive renal disease?. Am J Physiol Renal Physiol. 2006;291:F981–F986
  14. Spurgeon-Pechman KR, Donohoe DL, Mattson DL, Lund H, James L, Basile DP. Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium. Am J Physiol Renal Physiol. 2007;293:F269–F278
  15. Basile DP. The endothelial cell in ischemic acute kidney injury: Implications for acute and chronic function. Kidney Int. 2007;72:151–156
  16. Eddy AA. Progression in chronic kidney disease. Adv Chronic Kidney Dis. 2005;12:353–365
  17. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  18. Sarafidis PA, Bakris GL. Microalbuminuria and chronic kidney disease as risk factors for cardiovascular disease. Nephrol Dial Transplant. 2006;21:2366–2374
  19. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–1913
  20. Block CA, Schoolwerth AC. The epidemiology and outcome of acute renal failure and the impact on chronic kidney disease. Semin Dial. 2006;19:450–454
  21. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting (Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group). JAMA. 2000;283:2008–2012
  22. El-Shahawy MA, Agbing LU, Badillo E. Severity of illness scores and the outcome of acute tubular necrosis. Int Urol Nephrol. 2000;32:185–191
  23. Hamel MB, Phillips RS, Davis RB, et al. Outcomes and cost-effectiveness of initiating dialysis and continuing aggressive care in seriously ill hospitalized adults (SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Ann Intern Med. 1997;127:195–202
  24. Khan IH, Catto GR, Edward N, Macleod AM. Acute renal failure: Factors influencing nephrology referral and outcome. QJM. 1997;90:781–785
  25. Lindsay J, Apple S, Pinnow EE, et al. Percutaneous coronary intervention-associated nephropathy foreshadows increased risk of late adverse events in patients with normal baseline serum creatinine. Catheter Cardiovasc Interv. 2003;59:338–343
  26. Rocha PN, Rocha AT, Palmer SM, Davis RD, Smith SR. Acute renal failure after lung transplantation: Incidence, predictors and impact on perioperative morbidity and mortality. Am J Transplant. 2005;5:1469–1476
  27. Topkara VK, Dang NC, Barili F, et al. Predictors and outcomes of continuous veno-venous hemodialysis use after implantation of a left ventricular assist device. J Heart Lung Transplant. 2006;25:404–408
  28. Turney JH, Marshall DH, Brownjohn AM, Ellis CM, Parsons FM. The evolution of acute renal failure, 1956-1988. QJM. 1990;74:83–104
  29. Paramesh AS, Roayaie S, Doan Y, et al. Post-liver transplant acute renal failure: Factors predicting development of end-stage renal disease. Clin Transplant. 2004;18:94–99
  30. Bagshaw SM, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB. One-year mortality in critically ill patients by severity of kidney dysfunction: A population-based assessment. Am J Kidney Dis. 2006;48:402–409
  31. Hayden JA, Cote P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144:427–437
  32. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
  33. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  34. Welten GM, Schouten O, Chonchol M, et al. Temporary worsening of renal function after aortic surgery is associated with higher long-term mortality. Am J Kidney Dis. 2007;50:219–228
  35. Liano F, Felipe C, Tenorio MT, et al. Long-term outcome of acute tubular necrosis: A contribution to its natural history. Kidney Int. 2007;71:679–686
  36. Loef BG, Epema AH, Smilde TD, et al. Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival. J Am Soc Nephrol. 2005;16:195–200
  37. Abosaif NY, Tolba YA, Heap M, Russell J, El Nahas AM. The outcome of acute renal failure in the intensive care unit according to RIFLE: Model application, sensitivity, and predictability. Am J Kidney Dis. 2005;46:1038–1048
  38. Ahlstrom A, Tallgren M, Peltonen S, Rasanen P, Pettila V. Survival and quality of life of patients requiring acute renal replacement therapy. Intensive Care Med. 2005;31:1222–1228
  39. Akposso K, Hertig A, Couprie R, et al. Acute renal failure in patients over 80 years old: 25-Years' experience. Intensive Care Med. 2000;26:400–406
  40. Alric P, Hinchliffe RJ, Picot MC, et al. Long-term renal function following endovascular aneurysm repair with infrarenal and suprarenal aortic stent-grafts. J Endovasc Ther. 2003;10:397–405
  41. Askenazi DJ, Feig DI, Graham NM, Hui-Stickle S, Goldstein SL. 3-5 Year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int. 2006;69:184–189
  42. Bagshaw SM, Laupland KB, Doig CJ, et al. Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: A population-based study. Crit Care. 2005;9:R700–R709
  43. Bahar I, Akgul A, Ozatik MA, et al. Acute renal failure following open heart surgery: Risk factors and prognosis. Perfusion. 2005;20:317–322
  44. Barratt J, Parajasingam R, Sayers RD, Feehally J. Outcome of acute renal failure following surgical repair of ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2000;20:163–168
  45. Benoit DD, Hoste EA, Depuydt PO, et al. Outcome in critically ill medical patients treated with renal replacement therapy for acute renal failure: Comparison between patients with and those without haematological malignancies. Nephrol Dial Transplant. 2005;20:552–558
  46. Bhandari S, Turney JH. Survivors of acute renal failure who do not recover renal function. QJM. 1996;89:415–421
  47. Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ. Acute renal failure in intensive care units—Causes, outcome, and prognostic factors of hospital mortality; A prospective, multicenter study (French Study Group on Acute Renal Failure). Crit Care Med. 1996;24:192–198
  48. Chertow GM, Christiansen CL, Cleary PD, Munro C, Lazarus JM. Prognostic stratification in critically ill patients with acute renal failure requiring dialysis. Arch Intern Med. 1995;155:1505–1511
  49. Cosentino F, Chaff C, Piedmonte M. Risk factors influencing survival in ICU acute renal failure. Nephrol Dial Transplant. 1994;9(suppl 4):S179–S182
  50. Dahlberg PJ, Schaper A. Acute renal failure in octogenarians. Wis Med J. 1989;88:19–23
  51. Frost L, Pedersen RS, Bentzen S, Bille H, Hansen HE. Short and long term outcome in a consecutive series of 419 patients with acute dialysis-requiring renal failure. Scand J Urol Nephrol. 1993;27:453–462
  52. Gonwa TA, Mai ML, Melton LB, et al. Renal replacement therapy and orthotopic liver transplantation: The role of continuous veno-venous hemodialysis. Transplantation. 2001;71:1424–1428
  53. Gopal I, Bhonagiri S, Ronco C, Bellomo R. Out of hospital outcome and quality of life in survivors of combined acute multiple organ and renal failure treated with continuous venovenous hemofiltration/hemodiafiltration. Intensive Care Med. 1997;23:766–772
  54. Gruberg L, Mintz GS, Mehran R, et al. The prognostic implications of further renal function deterioration within 48 h of interventional coronary procedures in patients with pre-existent chronic renal insufficiency. J Am Coll Cardiol. 2000;36:1542–1548
  55. Gupta R, Gurm HS, Bhatt DL, Chew DP, Ellis SG. Renal failure after percutaneous coronary intervention is associated with high mortality. Catheter Cardiovasc Interv. 2005;64:442–448
  56. Hein OV, Birnbaum J, Wernecke KD, Konertz W, Jain U, Spies C. Three-year survival after four major post-cardiac operative complications. Crit Care Med. 2006;34:2729–2737
  57. Jones CH, Richardson D, Goutcher E, et al. Continuous venovenous high-flux dialysis in multiorgan failure: A 5-year single-center experience. Am J Kidney Dis. 1998;31:227–233
  58. Kaltenmaier B, Pommer W, Kaufmann F, Hennig E, Molzahn M, Hetzer R. Outcome of patients with ventricular assist devices and acute renal failure requiring renal replacement therapy. ASAIO J. 2000;46:330–333
  59. Korkeila M, Ruokonen E, Takala J. Costs of care, long-term prognosis and quality of life in patients requiring renal replacement therapy during intensive care. Intensive Care Med. 2000;26:1824–1831
  60. Landoni G, Zangrillo A, Franco A, et al. Long-term outcome of patients who require renal replacement therapy after cardiac surgery. Eur J Anaesthesiol. 2006;23:17–22
  61. Lins RL, Elseviers MM, Daelemans R. Severity scoring and mortality 1 year after acute renal failure. Nephrol Dial Transplant. 2006;21:1066–1068
  62. Luckraz H, Gravenor MB, George R, et al. Long and short-term outcomes in patients requiring continuous renal replacement therapy post cardiopulmonary bypass. Eur J Cardiothorac Surg. 2005;27:906–909
  63. McCarthy JT. Prognosis of patients with acute renal failure in the intensive-care unit: A tale of two eras. Mayo Clin Proc. 1996;71:117–126
  64. Miler M. Acute renal failure in children and its long-term follow-up treatment. Mon Sci Monit. 1997;3:563–572
  65. Morgera S, Kraft AK, Siebert G, Luft FC, Neumayer HH. Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies. Am J Kidney Dis. 2002;40:275–279
  66. Rihal CS, Textor SC, Grill DE, et al. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 2002;105:2259–2264
  67. Schiffl H. Renal recovery from acute tubular necrosis requiring renal replacement therapy: A prospective study in critically ill patients. Nephrol Dial Transplant. 2006;21:1248–1252
  68. Soares M, Salluh JI, Carvalho MS, Darmon M, Rocco JR, Spector N. Prognosis of critically ill patients with cancer and acute renal dysfunction. J Clin Oncol. 2006;24:4003–4010
  69. Sraer JD, Akposso K, Rondeau E. [Should acute kidney failure be treated in people over 80 years of age at an intensive care unit?]. Bull Acad Natl Med. 2000;184:1267–1277discussion 1277-1269
  70. Noble JS, Simpson K, Allison ME. Long-term quality of life and hospital mortality in patients treated with intermittent or continuous hemodialysis for acute renal and respiratory failure. Ren Fail. 2006;28:323–330
  71. Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: A comprehensive population-based study. J Am Soc Nephrol. 2007;18:1292–1298
  72. Turney JH, Ellis CM, Parsons FM. Obstetric acute renal failure 1956-1987. Br J Obstet Gynaecol. 1989;96:679–687
  73. Wong LP, Blackley MP, Andreoni KA, Chin H, Falk RJ, Klemmer PJ. Survival of liver transplant candidates with acute renal failure receiving renal replacement therapy. Kidney Int. 2005;68:362–370
  74. Coca SG, Peixoto AJ, Garg AX, Krumholz HM, Parikh CR. The prognostic importance of a small acute decrement in kidney function in hospitalized patients: A systematic review and meta-analysis. Am J Kidney Dis. 2007;50:712–720
  75. Kelly KJ. Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol. 2003;14:1549–1558
  76. Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int. 1999;55:2362–2367

 Originally published online as doi:10.1053/j.ajkd.2008.11.034 on April 6, 2009.

 This is a US Government Work. There are no restrictions on its use.

PII: S0272-6386(09)00079-1

doi: 10.1053/j.ajkd.2008.11.034

American Journal of Kidney Diseases
Volume 53, Issue 6 , Pages 961-973 , June 2009

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