American Journal of Kidney Diseases
Volume 53, Issue 5 , Pages 871-874 , May 2009

Methotrexate Clearance by High-Flux Hemodialysis and Peritoneal Dialysis: A Case Report

  • Miho Murashima, MD

      Affiliations

    • Department of Medicine, Renal Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Jill Adamski, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Michael C. Milone, MD, PhD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Leslie Shaw, PhD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Donald E. Tsai, MD

      Affiliations

    • Department of Medicine, Hematology and Oncology Division, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Roy D. Bloom, MD

      Affiliations

    • Department of Medicine, Renal Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, PA
    • Corresponding Author InformationAddress correspondence to Roy D. Bloom, MD, Renal Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104

Received 16 May 2008 ,Accepted 6 January 2009.

References 

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  3. Chess JA, Scholey G, Mikhail AI. Neutropenia associated with the use of low-dose methotrexate in a peritoneal dialysis patient. Nephrol Dial Transplant. 2004;19:2158–2159
  4. Yang CP, Kuo MC, Guh JY, Chen HC. Pancytopenia after low dose methotrexate therapy in a hemodialysis patient: Case report and review of literature. Ren Fail. 2006;28:95–97
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  8. Wall SM, Johansen MJ, Molony DA, DuBose TD, Jaffe N, Madden T. Effective clearance of methotrexate using high-flux hemodialysis membranes. Am J Kidney Dis. 1996;28:846–854
  9. Saland JM, Leavey PJ, Bash RO, Hansch E, Arbus GS, Quigley R. Effective removal of methotrexate by high-flux hemodialysis. Pediatr Nephrol. 2002;17:825–829
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  11. Pels H, Schmidt-Wolf I, Glasmacher A, et al. Primary central nervous system lymphoma: Results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy. J Clin Oncol. 2003;21:4489–4495
  12. Enting RH, Demopoulos A, DeAngelis LM, Abrey LE. Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide. Neurology. 2004;63:901–903
  13. Batchelor T, Carson K, O'Neill A, et al. Treatment of pimary CNS lymphoma with methotrexate and deferred radiotherapy: A report of NABTT 96-07. J Clin Oncol. 2003;21:1044–1049
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  16. Ahmad S, Shen F, Bleyer WA. Methotrexate-induced renal failure and ineffectiveness of peritoneal dialysis. Arch Intern Med. 1978;138:1146–1147
  17. Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB. Removal of methotrexate by peritoneal dialysis and hemodialysis in a single patient with end-stage renal disease. Am J Med Sci. 2006;332:156–158
  18. Steinberg SE, Campbell CL, Bleyer WA, Hillman RS. Enterohepatic circulation of methotrexate in rats in vivo. Cancer Res. 1982;42:1279–1282

 Originally published online as doi:10.1053/j.ajkd.2009.01.016 on April 2, 2009.

PII: S0272-6386(09)00082-1

doi: 10.1053/j.ajkd.2009.01.016

American Journal of Kidney Diseases
Volume 53, Issue 5 , Pages 871-874 , May 2009

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