American Journal of Kidney Diseases
Volume 53, Issue 5 , Pages 835-844 , May 2009

Solute Clearances and Fluid Removal in the Frequent Hemodialysis Network Trials

  • Tom Greene, PhD

      Affiliations

    • Corresponding Author InformationAddress correspondence to Tom Greene, PhD, Division of Epidemiology, University of Utah, 85 North Medical Drive, East Rm 201, Salt Lake City, UT 84112-5350
  • ,
  • John T. Daugirdas, MD
  • ,
  • Thomas A. Depner, MD
  • ,
  • Frank Gotch, MD
  • ,
  • Martin Kuhlman, MD
  • ,
  • Frequent Hemodialysis Network Study Group
  • ,
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • ,
  • National Institutes of Health

Received 16 July 2008 ,Accepted 26 December 2008.

References 

  1. Suri RS, Garg AX, Chertow GM, et al. Frequent Hemodialysis Network Trial Group Frequent Hemodialysis Network (FHN) randomized trials: Study design. Kidney Int. 2007;71:349–359
  2. Suri RS, Nesrallah GE, Mainra R, et al. Daily hemodialysis: A systematic review. Clin J Am Soc Nephrol. 2006;1:33–42
  3. Kliger AS Frequent Hemodialysis Network Study Group. High-frequency hemodialysis: Rationale for randomized clinical trials. Clin J Am Soc Nephrol. 2007;2:390–392
  4. Eknoyan G, Beck G, Cheung A, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347:2010–2019
  5. Daugirdas JT, Greene T, Depner TA, et al. HEMO Study Group Factors affecting postdialysis rebound in serum urea concentration, including the rate of dialysis: Results from the HEMO Study. J Am Soc Nephrol. 2004;15:194–203
  6. Michaels A. Operating parameters and performance criteria for hemodialyzers and other membrane-separation devices. Trans Am Soc Artif Intern Organs. 1996;12:387–392
  7. Press W, Flannery B, Teukolsky S, Vetterling W. Numerical recipes, in Integration of Ordinary Differential Equations. In: New York, NY: Cambridge University; 1986;p. 547–577
  8. Daugirdas JT, Depner TA, Gotch FA, et al. HEMO Study Group Comparison of methods to predict equilibrated Kt/V in the HEMO Pilot Study. Kidney Int. 1997;52:1395–1405
  9. Depner T, Greene T, Daugirdas J, Cheung A, Gotch F, Leypoldt J HEMO Study. Dialyzer performance in the HEMO Study: In vivo K0A and true blood flow determined from a model of cross-dialyzer urea extraction. ASAIO J. 2004;50:85–93
  10. Ahmed J, Besarab A, Lubkowski T, Frinak S. Effect of differing blood lines on delivered blood flow during hemodialysis. Am J Kidney Dis. 2004;44:498–508
  11. Depner TA. Prescribing Hemodialysis: A Guide to Urea Modeling. Norwell, MA: Kluwer Academic; 1991;
  12. Depner TA, Cheer A. Modeling urea kinetics with two vs. three BUN measurements (A critical comparison). ASAIO Trans. 1989;35:499–502
  13. Tattersall JE, DeTakats D, Chamney P, Greenwood RN, Farrington K. The post-hemodialysis rebound: Predicting and quantifying its effect on Kt/V. Kidney Int. 1996;50:2094–2102
  14. Daugirdas JT, Greene T, Depner TA, Gotch FA, Star RA Hemodialysis (HEMO) Study Group. Relation between apparent (single-pool) and true (double-pool) urea distribution volume in the HEMO Study. Kidney Int. 1999;56:1928–1933
  15. Rousseeuw PJ, Leroy A. Robust Regression and Outlier Detection. New York, NY: Wiley; 1987;
  16. Ward RA, Greene T, Hartmann B, Samtleben W. Resistance to intercompartmental mass transfer limits beta2-microglobulin removal by post-dilution hemodiafiltration. Kidney Int. 2006;69:1431–1437
  17. Clark W, Leypoldt J, Henderson L, Mueller B, Scott M, Vonesh E. Quantifying the effect of changes in the hemodialysis prescription on effective solute removal with a mathematical model. J Am Soc Nephrol. 1999;10:601–609
  18. Cheung AK, Agodoa LY, Daugirdas JT, et al. Hemodialysis (HEMO) Study Group Effects of hemodialyzer reuse clearances of urea and β2-microglobulin. J Am Soc Nephrol. 1999;10:117–127
  19. Gotch FA. The current place of urea kinetic modelling with respect to different dialysis modalities. Nephrol Dial Transplant. 1998;13(suppl 6):S10–S14
  20. Leypoldt JK, Jaber BL, Zimmerman DL. Predicting treatment dose for novel therapies using urea standard Kt/V. Semin Dial. 2004;17:142–145
  21. Casino FG, Lopez T. The equivalent renal urea clearance: A new parameter to assess dialysis dose. Nephrol Dial Transplant. 1996;11:1574–1581
  22. Livingston E, Lee S. Body surface area prediction in normal-weight and obese patients. Am J Physiol Endocrinol Metab. 2001;281:E586–E591
  23. Agar JWM, Mahadevan K, Pellicano R, Kerr P. Comparing two nocturnal hemodialysis programs with different frequencies. J Am Soc Nephrol. 2004;14:403A;(abstr)
  24. Charra B, Chazot C, Jean G, et al. Long 3 × 8 hr dialysis: A three-decade summary. J Nephrol. 2003;16(suppl 7):S64–S69
  25. Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr. 1980;33:27–39
  26. Ayus JC, Achinger SG, Mizani MR, et al. Phosphorus balance and mineral metabolism with 3 h daily hemodialysis. Kidney Int. 2007;71:336–342

 Trial registration: www.clinicaltrials.gov; study numbers: NCT00264758 and NCT00271999.

 A list of the members of the Frequent Hemodialysis Network Study Group appears at the end of this article.

 Because the Editor-in-Chief recused himself from consideration of this manuscript, the Deputy Editor (Daniel E. Weiner, MD, MS, Tufts Medical Center) served as Acting Editor-in-Chief. Details of the journal's procedures for potential editor conflicts are given in the Editorial Policies section of the AJKD website.

 Originally published online as doi:10.1053/j.ajkd.2008.12.039 on April 2, 2009.

PII: S0272-6386(09)00401-6

doi: 10.1053/j.ajkd.2008.12.039

American Journal of Kidney Diseases
Volume 53, Issue 5 , Pages 835-844 , May 2009