American Journal of Kidney Diseases
Volume 54, Issue 2 , Pages 248-261 , August 2009

Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies

  • Sarah L. White, MPH

      Affiliations

    • The George Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    • Corresponding Author InformationAddress correspondence to Sarah L. White, MPH, The George Institute, PO Box M201, Missenden Rd, Sydney, NSW, 2050 Australia
    • ,
  • Vlado Perkovic, FRACP, PhD

      Affiliations

    • The George Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    • ,
  • Alan Cass, FRACP, PhD

      Affiliations

    • The George Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    • ,
  • Choon Lan Chang, PhD

      Affiliations

    • Preventive Cardiovascular Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, UK
    • ,
  • Neil R. Poulter, FRCP, MSc, PhD

      Affiliations

    • Preventive Cardiovascular Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, UK
    • ,
  • Tim Spector, FRCP, MD

      Affiliations

    • Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Kings College, London, UK
    • ,
  • Leigh Haysom, FRACP, PhD

      Affiliations

    • Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia
    • ,
  • Jonathan C. Craig, FRACP, PhD

      Affiliations

    • Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia
    • School of Public Health, Faculty of Medicine, University of Sydney, Sydney, Australia
    • ,
  • Isa Al Salmi, FRACP, MD

      Affiliations

    • Centre for Chronic Disease, The University of Queensland, Brisbane, Australia
    • ,
  • Steven J. Chadban, FRACP, PhD

      Affiliations

    • Department of Medicine, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    • ,
  • Rachel R. Huxley, DPhil

      Affiliations

    • The George Institute, Faculty of Medicine, University of Sydney, Sydney, Australia

Received 7 October 2008 ,Accepted 24 December 2008.

References 

  1. Barker DJ. The fetal and infant origins of adult disease. BMJ. 1990;301:1111
  2. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993;307:1524–1527
  3. Phipps K, Barker DJ, Hales CN, Fall CH, Osmond C, Clark PM. Fetal growth and impaired glucose tolerance in men and women. Diabetologia. 1993;36:225–228
  4. Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990;301:259–262
  5. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  6. Chadban SJ, Briganti EM, Kerr PG, et al. Prevalence of kidney damage in Australian adults: The AusDiab kidney study. J Am Soc Nephrol. 2003;14(suppl 2):S131–S138
  7. Perkovic V, Cass A, Patel AA, et al. High prevalence of chronic kidney disease in Thailand. Kidney Int. 2008;73:473–479
  8. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure: Less of one, more the other?. Am J Hypertens. 1988;1:335–347
  9. Brenner BM, Mackenzie HS. Nephron mass as a risk factor for progression of renal disease. Kidney Int Suppl. 1997;63:S124–S127
  10. Li S, Chen SC, Shlipak M, et al. Low birth weight is associated with chronic kidney disease only in men. Kidney Int. 2008;73:637–642
  11. Hallan S, Euser AM, Irgens LM, Finken MJ, Holmen J, Dekker FW. Effect of intrauterine growth restriction on kidney function at young adult age: The Nord Trondelag Health (HUNT 2) Study. Am J Kidney Dis. 2008;51:10–20
  12. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
  13. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting (Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group). JAMA. 2000;283:2008–2012
  14. Lackland DT, Bendall HE, Osmond C, Egan BM, Barker DJ. Low birth weights contribute to high rates of early-onset chronic renal failure in the Southeastern United States. Arch Intern Med. 2000;160:1472–1476
  15. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  16. Nelson RG, Morgenstern H, Bennett PH. Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus. Am J Epidemiol. 1998;148:650–656
  17. Rudberg S, Stattin EL, Dahlquist G. Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients. Diabetes. 1998;47:1121–1126
  18. Hoy WE, Rees M, Kile E, Mathews JD, Wang Z. A new dimension to the Barker hypothesis: Low birthweight and susceptibility to renal disease. Kidney Int. 1999;56:1072–1077
  19. Ramirez SP, Hsu SI, McClellan W. Low body weight is a risk factor for proteinuria in multiracial Southeast Asian pediatric population. Am J Kidney Dis. 2001;38:1045–1054
  20. Yudkin JS, Martyn CN, Phillips DI, Gale CR. Associations of micro-albuminuria with intra-uterine growth retardation. Nephron. 2001;89:309–314
  21. Dyck R, Klomp H, Tan L, Stang MR. An association of maternal age and birth weight with end-stage renal disease in Saskatchewan (Sub-analysis of registered Indians and those with diabetes). Am J Nephrol. 2003;23:395–402
  22. Painter RC, Roseboom TJ, van Montfrans GA, et al. Microalbuminuria in adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol. 2005;16:189–194
  23. Fagerudd J, Forsblom C, Pettersson-Fernholm K, et al. Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients. Nephrol Dial Transplant. 2006;21:2159–2165
  24. Fan ZJ, Lackland DT, Lipsitz SR, Nicholas JS. The association of low birthweight and chronic renal failure among Medicaid young adults with diabetes and/or hypertension. Public Health Rep. 2006;121:239–244
  25. Al Salmi I, Hoy W, Kondalsamy-Chennakesavan S, et al. Lower glomerular filtration rate in adults with low birth weight: Results from the AusDiab study. J Am Soc Nephrol. 2007;18:47A;(abstr SA-FC055)
  26. Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol. 2008;19:151–157
  27. Vasarhelyi B, Dobos M, Reusz GS, Szabo A, Tulassay T. Normal kidney function and elevated natriuresis in young men born with low birth weight. Pediatr Nephrol. 2000;15:96–100
  28. Al Salmi I, Hoy W, Kondalsamy-Chennakesavan S, et al. Adult chronic kidney disease patients have lower birth weight than the general Australian population. J Am Soc Nephrol. 2007;18:824A;(abstr SU-PO1076)
  29. Sandeman DD, Reza M, Phillips DI, Barker DPJ, Osmond C, Leatherdale BA. Why do some type 1 diabetic patients develop nephropathy? (A possbile role of birth weight). Diabet Med. 1992;9:S36A;(suppl 1; abstr P93)
  30. Rossing P, Tarnow L, Nielsen FS, Hansen BV, Brenner BM, Parving HH. Low birth weight (A risk factor for development of diabetic nephropathy?). Diabetes. 1995;44:1405–1407
  31. Vestbo E, Damsgaard EM, Froland A, Mogensen CE. Birth weight and cardiovascular risk factors in an epidemiological study. Diabetologia. 1996;39:1598–1602
  32. Yudkin JS, Phillips DI, Stanner S. Proteinuria and progressive renal disease: Birth weight and microalbuminuria. Nephrol Dial Transplant. 1997;12(suppl 2):S10–S13
  33. Erbey J, Libman I, Wilson R, Gower I. Low birth weight and early development of microalbuminuria in insulin-dependent diabetes. Diabetes. 1997;46:S122A;(suppl 1; abstr)
  34. McAllister AS, Atkinson AB, Johnston GD, McCance DR. Relationship of endothelial function to birth weight in humans. Diabetes Care. 1999;22:2061–2066
  35. Bo S, Cavallo-Perin P, Scaglione L, Pagano G. Lack of association of fibrinogen, lipoprotein(a), and albumin excretion rate with low birthweight. Int J Clin Lab Res. 2000;30:203–205
  36. Kistner A, Celsi G, Vanpee M, Jacobson SH. Increased blood pressure but normal renal function in adult women born preterm. Pediatr Nephrol. 2000;15:215–220
  37. Johnsen SP, Sorensen HT, Thulstrup AM, Norgard B, Engberg M, Lauritzen T. Fetal growth and urinary albumin excretion among middle-aged Danes. Scand J Urol Nephrol. 2001;35:314–318
  38. Eshoj O, Vaag A, Borch-Johnsen K, Feldt-Rasmussen B, Beck-Nielsen H. Is low birth weight a risk factor for the development of diabetic nephropathy in patients with type 1 diabetes? (A population-based case-control study). J Intern Med. 2002;252:524–528
  39. Laganovic M, Kuzmanic D, Jelakovic B, et al. Microalbuminuria, independently of birth weight, correlates with blood pressure in early phase of essential hypertension. J Hypertens. 2002;20:SO056;(suppl 4; abstr)
  40. Iotova V, Madjova V, Tzaneva V. Does size at birth influence the development of microalbuminuria in young patients with type 1 diabetes mellitus?. Endocrinologia. 2002;7:23–29
  41. Huxley RR, Neil HA. Does maternal nutrition in pregnancy and birth weight influence levels of CHD risk factors in adult life?. Br J Nutr. 2004;91:459–468
  42. Gielen M, Pinto-Sietsma SJ, Zeegers MP, et al. Birth weight and creatinine clearance in young adult twins: Influence of genetic, prenatal, and maternal factors. J Am Soc Nephrol. 2005;16:2471–2476
  43. Poulter NR, Chang CL, MacGregor AJ, Snieder H, Spector TD. Association between birth weight and adult blood pressure in twins: Historical cohort study. BMJ. 1999;319:1330–1333
  44. Haysom L, Williams R, Hodson E, Roy LP, Lyle D, Craig JC. Early chronic kidney disease in Aboriginal and non-Aboriginal Australian children: Remoteness, socioeconomic disadvantage or race?. Kidney Int. 2007;71:787–794
  45. Taylor TP, Wang W, Shrayyef MZ, Cheek D, Hutchison FN, Gadegbeku CA. Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy x-ray absorptiometry. Nephrol Dial Transplant. 2006;21:84–87
  46. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247–254
  47. Cirillo M, Anastasio P, De Santo NG. Relationship of gender, age, and body mass index to errors in predicted kidney function. Nephrol Dial Transplant. 2005;20:1791–1798
  48. Lawlor DA, Ebrahim S, Davey Smith G. Is there a sex difference in the association between birth weight and systolic blood pressure in later life? (Findings from a meta-regression analysis). Am J Epidemiol. 2002;156:1100–1104
  49. Kramer MS. Invited commentary: Association between restricted fetal growth and adult chronic disease: Is it causal? (Is it important?). Am J Epidemiol. 2000;152:605–608
  50. Williams S, Poulton R. Twins and maternal smoking: Ordeals for the fetal origins hypothesis? (A cohort study). BMJ. 1999;318:897–900
  51. Amri K, Freund N, Vilar J, Merlet-Benichou C, Lelievre-Pegorier M. Adverse effects of hyperglycemia on kidney development in rats: In vivo and in vitro studies. Diabetes. 1999;48:2240–2245
  52. Nelson RG, Morgenstern H, Bennett PH. Intrauterine diabetes exposure and the risk of renal disease in diabetic Pima Indians. Diabetes. 1998;47:1489–1493
  53. Shoham DA, Vupputuri S, Kshirsagar AV. Chronic kidney disease and life course socioeconomic status: A review. Adv Chronic Kidney Dis. 2005;12:56–63
  54. Poulton R, Caspi A, Milne BJ, et al. Association between children's experience of socioeconomic disadvantage and adult health: A life-course study. Lancet. 2002;360:1640–1645
  55. Lynch JW, Kaplan GA, Shema SJ. Cumulative impact of sustained economic hardship on physical, cognitive, psychological, and social functioning. N Engl J Med. 1997;337:1889–1895
  56. Singh-Manoux A, Ferrie JE, Chandola T, Marmot M. Socioeconomic trajectories across the life course and health outcomes in midlife: Evidence for the accumulation hypothesis?. Int J Epidemiol. 2004;33:1072–1079
  57. Huxley R, Neil A, Collins R. Unravelling the fetal origins hypothesis: Is there really an inverse association between birthweight and subsequent blood pressure?. Lancet. 2002;360:659–665
  58. Huxley R, Owen CG, Whincup PH, Cook DG, Colman S, Collins R. Birth weight and subsequent cholesterol levels: Exploration of the “fetal origins” hypothesis. JAMA. 2004;292:2755–2764
  59. Newsome CA, Shiell AW, Fall CH, Phillips DI, Shier R, Law CM. Is birth weight related to later glucose and insulin metabolism? (A systematic review). Diabet Med. 2003;20:339–348
  60. Bassan H, Trejo LL, Kariv N, et al. Experimental intrauterine growth retardation alters renal development. Pediatr Nephrol. 2000;15:192–195
  61. Merlet-Benichou C, Gilbert T, Muffat-Joly M, Lelievre-Pegorier M, Leroy B. Intrauterine growth retardation leads to a permanent nephron deficit in the rat. Pediatr Nephrol. 1994;8:175–180
  62. Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient restriction in sheep: Hypertension and decreased nephron number in offspring at 9 months of age. J Physiol. 2005;565:137–147
  63. Hinchliffe SA, Lynch MR, Sargent PH, Howard CV, Van Velzen D. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol. 1992;99:296–301
  64. Hinchliffe SA, Howard CV, Lynch MR, Sargent PH, Judd BA, van Velzen D. Renal developmental arrest in sudden infant death syndrome. Pediatr Pathol. 1993;13:333–343
  65. Farris A, Hughson MD, Betram JF, Douglas-Denton R, Hoy WE. Birth weight is a powerful determinant of total nephron number. J Am Soc Nephrol. 2002;13:102A–103A(abstr)
  66. Hughson M, Farris AB, Douglas-Denton R, Hoy WE, Bertram JF. Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int. 2003;63:2113–2122
  67. Hughson MD, Douglas-Denton R, Bertram JF, Hoy WE. Hypertension, glomerular number, and birth weight in African Americans and white subjects in the Southeastern United States. Kidney Int. 2006;69:671–678
  68. Nyengaard JR, Bendtsen TF, Mogensen CE. Low birth weight: Is it associated with few and small glomeruli in normal subjects and NIDDM patients?. Diabetologia. 1996;39:1634–1637
  69. Ingelfinger JR. Pathogenesis of perinatal programming. Curr Opin Nephrol Hypertens. 2004;13:459–464
  70. Sterne JA, Egger M, Smith GD. Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323:101–105
  71. Egger M, Smith GD, Phillips AN. Meta-analysis: Principles and procedures. BMJ. 1997;315:1533–1537
  72. Egger M, Schneider M, Davey Smith G. Spurious precision? (Meta-analysis of observational studies). BMJ. 1998;316:140–144

 Originally published online as doi: 10.1053/j.ajkd.2008.12.042 on April 2, 2009.

PII: S0272-6386(09)00422-3

doi: 10.1053/j.ajkd.2008.12.042

American Journal of Kidney Diseases
Volume 54, Issue 2 , Pages 248-261 , August 2009

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