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American Journal of Kidney Diseases
Volume 54, Issue 3
, Pages 478-489
, September 2009
Homocysteine as a Risk Factor for Cardiovascular Disease in Patients Treated by Dialysis: A Meta–analysis
References
- . Effect of age and diagnosis on survival of older patients beginning chronic dialysis. JAMA. 1994;271:34–36
- “U” Curve association of blood pressure and mortality in hemodialysis patients (Medical Directors of Dialysis Clinic, Inc.). Kidney Int. 1998;54:561–569
- . Are conventional cardiovascular risk factors predictive of two-year mortality in hemodialysis patients?. Clin Nephrol. 2001;56:221–230
- . Homocysteine and vascular disease. Nat Med. 1996;2:386–389
- The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006;136(suppl 6):S1731–S1740
- . Third National Health and Nutrition Examination Survey (Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey, 1988-1994). Am J Clin Nutr. 2003;77:826–833
- . Renal disease, homocysteine, and cardiovascular complications. Circulation. 2004;109:294–295
- Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: A multicenter observational study. Arterioscler Thromb Vasc Biol. 2001;21:2080–2085
- . A quantitative assessment of plasma homocysteine as a risk factor for vascular disease (Probable benefits of increasing folic acid intakes). JAMA. 1995;274:1049–1057
- . Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ. 2002;325:1202–1206
- . Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA. 2002;288:2015–2022
- . Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials. Am J Clin Nutr. 2005;82:806–812
- Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291:565–575
- Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006;354:1578–1588
- Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567–1577
- . Homocysteine-lowering is not a primary target for cardiovascular disease prevention in chronic kidney disease patients. Semin Dial. 2007;20:523–529
- Meta-analysis of observational studies in epidemiology: A proposal for reporting (Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group). JAMA. 2000;283:2008–2012
- . Improving the quality of reports of meta-analyses of randomised controlled trials: The QUOROM statement (Quality of Reporting of Meta-analyses). Lancet. 1999;354:1896–1900
- . Systematic reviews of trials and other studies. Health Technol Assess. 1998;2:1–276
- . Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188
- . A comparison of statistical methods for meta-analysis. Stat Med. 2001;20:825–840
- . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634
- . Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
- . Re: “A critical look at some popular meta-analytic methods.”. Am J Epidemiol. 1994;140:297–299
- . Methods for exploring heterogeneity in meta-analysis. Eval Health Prof. 2001;24:126–151
- . Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA. 1991;266:93–98
- Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis. Metabolism. 2006;55:656–661
- Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients. J Am Soc Nephrol. 1995;6:121–125
- Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: A case-control study. Atherosclerosis. 1995;114:93–103
- Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese patients with end-stage renal disease. Clin Nephrol. 2001;56:132–139
- Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: Is homocyst(e)ine the missing link?. Nephrol Dial Transplant. 1999;14:1934–1942
- . Hyperhomocyst(e)inemia and the prevalence of atherosclerotic vascular disease in patients with end-stage renal disease. Am J Kidney Dis. 1999;34:669–677
- Elevated homocysteine levels in patients with end-stage renal disease. Mt Sinai J Med. 2005;72:365–373
- Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation. 1996;94:2743–2748
- Hyperhomocysteinemia, nutritional status, and cardiovascular disease in hemodialysis patients. Kidney Int. 2000;57:1727–1735
- Major determinants of hyperhomocysteinemia in peritoneal dialysis patients. Kidney Int. 1998;53:1775–1782
- . An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. Kidney Int. 2001;60:1106–1113
- Homocysteine, C-reactive protein, lipid peroxidation and mortality in haemodialysis patients. Nephrol Dial Transplant. 2003;18:106–112
- Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients (A prospective study). Arterioscler Thromb Vasc Biol. 1997;17:2554–2558
- . Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease. J Nephrol. 2004;17:405–410
- Cardiac troponin T predicts mortality in patients with end-stage renal disease. Circulation. 2000;102:1964–1969
- . C-Reactive protein and cardiovascular disease in peritoneal dialysis patients. Kidney Int. 2002;62:1417–1422
- . Impact of malnutrition-inflammation on the association between homocysteine and mortality. Kidney Int. 2006;69:331–335
- . A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients. J Am Soc Nephrol. 2004;15:442–453
- . Forearm reactive hyperemia and mortality in end-stage renal disease. Kidney Int. 2004;65:700–704
- Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients. Kidney Int. 2002;61:609–614
- Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation. 1998;97:138–141
- Homocyst(e)ine and vascular access complications in haemodialysis patients: Insights into a complex metabolic relationship. Nephrol Dial Transplant. 1999;14:738–743
- Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial. JAMA. 2007;298:1163–1170
- Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients. Med Sci Monit. 2003;9:PI19–PI24
- . Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif. 2006;24:379–386
- Uremic hyperhomocysteinemia: A randomized trial of folate treatment for the prevention of cardiovascular events. Hemodial Int. 2007;11:210–216
- . Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. J Am Soc Nephrol. 2004;15:420–426
- Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: Effect of oral therapy with folic acid and vitamin B12. Nephrol Dial Transplant. 2002;17:455–461
- . Response of hyperhomocysteinemia to folic acid supplementation in patients with end-stage renal disease. Clin Nephrol. 1999;51:108–115
- Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: Results of the Vienna multicenter study. J Am Soc Nephrol. 2000;11:1106–1116
- . Homocysteine and atherothrombosis—Mechanisms for injury. Eur Heart J. 2000;21:967–974
- Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet. 2003;361:1693–1699
- Trends in circulating concentrations of total homocysteine among US adolescents and adults: Findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys. Clin Chem. 2008;54:801–813
- Mild renal insufficiency is associated with angiographic coronary artery disease in women. Circulation. 2002;105:2826–2829
- Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study. Kidney Int. 2002;62:1402–1407
- . Two cardiovascular risk factors in one? (Homocysteine and its relation to glomerular filtration rate. A meta-analysis of 41 studies with 27,000 participants). Kidney Blood Press Res. 2008;31:259–267
- . Dietary determinants of plasma homocysteine concentrations. Semin Vasc Med. 2005;5:110–123
- Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am J Clin Nutr. 2007;86:1405–1413
- Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients. Atherosclerosis. 1996;123:193–202
Originally published online as doi: 10.1053/j.ajkd.2009.01.266 on April 9, 2009.
J.H. and S.K. contributed equally to this article.
PII: S0272-6386(09)00438-7
doi: 10.1053/j.ajkd.2009.01.266
© 2009 National Kidney Foundation, Inc. Published by Elsevier Inc All rights reserved.
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American Journal of Kidney Diseases
Volume 54, Issue 3
, Pages 478-489
, September 2009
