American Journal of Kidney Diseases
Volume 53, Issue 6 , Pages 1002-1013 , June 2009

Systematic Review of the Evidence Underlying the Association Between Mineral Metabolism Disturbances and Risk of Fracture and Need for Parathyroidectomy in CKD

  • David Goldsmith, MA, FRCP

      Affiliations

    • Guy's Hospital, London, UK
    • Corresponding Author InformationAddress correspondence to David Goldsmith, MA, FRCP, Guy's Hospital, London, UK
    • ,
  • Prajesh Kothawala, MD, MPH

      Affiliations

    • Cerner LifeSciences, Beverly Hills, CA
    • ,
  • Arpi Chalian, MD

      Affiliations

    • Cerner LifeSciences, Beverly Hills, CA
    • ,
  • Myriam Bernal, MD, MPH

      Affiliations

    • Cerner LifeSciences, Beverly Hills, CA
    • ,
  • Sean Robbins, MS

      Affiliations

    • Amgen (Europe) GmbH, Zug, Switzerland
    • ,
  • Adrian Covic, MD, PhD, FRCP

      Affiliations

    • C.I. Parhon University Hospital, Iasi, Romania

Received 3 December 2008 ,Accepted 13 February 2009.

References 

  1. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  2. US Renal Data Systems. USRDS 2007 Annual Data Report. Bethesda, MD: The National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2007;
  3. European Renal Association-European Dialysis Transplant Association. 2005 Annual Data Report Paris, France, European Renal Association-European Dialysis Transplant Association. 2005;June 2007 2008
  4. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  5. Slinin Y, Foley RN, Collins AJ. Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: The USRDS Waves 1, 3, and 4 Study. J Am Soc Nephrol. 2005;16:1788–1793
  6. Alem AM, Sherrard DJ, Gillen DL, et al. Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int. 2000;58:396–399
  7. Nickolas TL, McMahon DJ, Shane E. Relationship between moderate to severe kidney disease and hip fracture in the United States. J Am Soc Nephrol. 2006;17:3223–3232
  8. Ball AM, Gillen DL, Sherrard D, et al. Risk of hip fracture among dialysis and renal transplant recipients. JAMA. 2002;288:3014–3018
  9. Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis. 2000;36:1115–1121
  10. Danese MD, Kim J, Doan QV, Dylan M, Griffiths R, Chertow GM. PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis. Am J Kidney Dis. 2006;47:149–156
  11. Mittalhenkle A, Gillen DL, Stehman-Breen CO. Increased risk of mortality associated with hip fracture in the dialysis population. Am J Kidney Dis. 2004;44:672–679
  12. Dooley AC, Weiss NS, Kestenbaum B. Increased risk of hip fracture among men with CKD. Am J Kidney Dis. 2008;51:38–44
  13. Stehman-Breen CO, Sherrard DJ, Alem AM, et al. Risk factors for hip fracture among patients with end-stage renal disease. Kidney Int. 2000;58:2200–2205
  14. Desmet C, Beguin C, Swine C, Jadoul M. Falls in hemodialysis patients: Prospective study of incidence, risk factors, and complications. Am J Kidney Dis. 2005;45:148–153
  15. Cunningham J, Sprague SM, Cannata-Andia J, et al. Osteoporosis in chronic kidney disease. Am J Kidney Dis. 2004;43:566–571
  16. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women (Study of Osteoporotic Fractures Research Group). N Engl J Med. 1995;332:767–773
  17. Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease. Kidney Int. 2007;71:31–38
  18. Zehnder D, Landray MJ, Wheeler DC, et al. Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients (The Chronic Renal Impairment in Birmingham (CRIB) Study). Nephron Clin Pract. 2007;107:c109–c116
  19. Young EW, Akiba T, Albert JM, et al. Magnitude and impact of abnormal mineral metabolism in hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2004;44:S34–S38(suppl 2)
  20. Drueke TB, Moe SM. Disturbances of bone and mineral metabolism in chronic kidney disease: An international initiative to improve diagnosis and treatment. Nephrol Dial Transplant. 2004;19:534–536
  21. Covic A, Kothawala P, Bernal M, Robbins S, Chalian A, Goldsmith D. Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality, cardiovascular mortality and cardiovascular events in chronic kidney disease. Nephrol Dial Transplant. 2009;24:1506–1523
  22. Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. Ann Intern Med. 2007;147:W163–W194
  23. Atsumi K, Kushida K, Yamazaki K, Shimizu S, Ohmura A, Inoue T. Risk factors for vertebral fractures in renal osteodystrophy. Am J Kidney Dis. 1999;33:287–293
  24. Kaneko TM, Foley RN, Gilbertson DT, Collins AJ. Clinical epidemiology of long-bone fractures in patients receiving hemodialysis. Clin Orthop Relat Res. 2007;457:188–193
  25. Jadoul M, Albert JM, Akiba T, et al. Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2006;70:1358–1366
  26. Jorna FH, Tobe TJ, Huisman RM, de Jong PE, Plukker JT, Stegeman CA. Early identification of risk factors for refractory secondary hyperparathyroidism in patients with long-term renal replacement therapy. Nephrol Dial Transplant. 2004;19:1168–1173
  27. Slinin Y, Foley RN, Collins AJ. Clinical epidemiology of parathyroidectomy in hemodialysis patients: The USRDS Waves 1, 3, and 4 Study. Hemodial Int. 2007;11:62–71
  28. Young EW, Albert JM, Satayathum S, et al. Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns Study. Kidney Int. 2005;67:1179–1187
  29. US Renal Data Systems. USRDS 2005 Annual Data Report. Bethesda, MD: The National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2005;
  30. Joly D, Drueke TB, Alberti C, et al. Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: A cross-sectional study. Am J Kidney Dis. 2008;51:987–995
  31. Kestenbaum B, Belozeroff V. Mineral metabolism disturbances in patients with chronic kidney disease. Eur J Clin Invest. 2007;37:607–622
  32. Hruska KA, Teitelbaum SL. Renal osteodystrophy. N Engl J Med. 1995;333:166–174
  33. Slatopolsky E, Brown A, Dusso A. Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis. 2001;37:S54–S57(suppl 2)
  34. Gal-Moscovici A, Sprague SM, Hutchison AJ, Shah N, Piraino B, Cunningham J. Which of the K/DOQI guidelines for bone disease in dialysis patients should be changed?. Semin Dial. 2007;20:24–32
  35. Foley RN, Li S, Liu J, Gilbertson DT, Chen SC, Collins AJ. The fall and rise of parathyroidectomy in U.S. hemodialysis patients, 1992 to 2002. J Am Soc Nephrol. 2005;16:210–218
  36. Cunningham J, Danese M, Olson K, Klassen P, Chertow GM. Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism. Kidney Int. 2005;68:1793–1800

PII: S0272-6386(09)00444-2

doi: 10.1053/j.ajkd.2009.02.010

American Journal of Kidney Diseases
Volume 53, Issue 6 , Pages 1002-1013 , June 2009

Article Tools

* Image Usage & Resolution