American Journal of Kidney Diseases
Volume 54, Issue 2 , Pages 270-277 , August 2009

Serum Bicarbonate Levels and the Progression of Kidney Disease: A Cohort Study

Received 14 October 2008 ,Accepted 12 February 2009.

References 

  1. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  2. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
  3. O'Hare AM, Choi AI, Bertenthal D, et al. Age affects outcomes in chronic kidney disease. J Am Soc Nephrol. 2007;18:2758–2765
  4. Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345:851–860
  5. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy (The Collaborative Study Group). N Engl J Med. 1993;329:1456–1462
  6. Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001;345:861–869
  7. US Renal Data System. USRDS 2006 Annual Data Report. Bethesda, MD: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease; 2006;
  8. Nath KA, Hostetter MK, Hostetter TH. Ammonia-complement interaction in the pathogenesis of progressive renal injury. Kidney Int Suppl. 1989;27:S52–S54
  9. Nath KA, Hostetter MK, Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats (Interactions of dietary acid load, ammonia, and complement component C3). J Clin Invest. 1985;76:667–675
  10. Gadola L, Noboa O, Marquez MN, et al. Calcium citrate ameliorates the progression of chronic renal injury. Kidney Int. 2004;65:1224–1230
  11. Throssell D, Brown J, Harris KP, Walls J. Metabolic acidosis does not contribute to chronic renal injury in the rat. Clin Sci (Lond). 1995;89:643–650
  12. Southern WN, Berger MA, Bellin EY, Hailpern SM, Arnsten JH. Hospitalist care and length of stay in patients requiring complex discharge planning and close clinical monitoring. Arch Intern Med. 2007;167:1869–1874
  13. Tarver-Carr ME, Powe NR, Eberhardt MS, et al. Excess risk of chronic kidney disease among African American versus white subjects in the United States: A population-based study of potential explanatory factors. J Am Soc Nephrol. 2002;13:2363–2370
  14. Torres VE, Cowley BD, Branden MG, Yoshida I, Gattone VH. Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. Exp Nephrol. 2001;9:171–180
  15. MacClean AJ, Hayslett JP. Adaptive change in ammonia excretion in renal insufficiency. Kidney Int. 1980;17:595–606
  16. Pangburn MK, Schreiber RD, Muller-Eberhard HJ. Formation of the initial C3 convertase of the alternative complement pathway (Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3). J Exp Med. 1981;154:856–867
  17. Nath KA, Hostetter MK, Hostetter TH. Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis. 1991;17:654–657
  18. Widmer B, Gerhardt RE, Harrington JT, Cohen JJ. Serum electrolyte and acid base composition (The influence of graded degrees of chronic renal failure). Arch Intern Med. 1979;139:1099–1102
  19. Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int. 2004;65:1031–1040
  20. Gennari FJ, Hood VL, Greene T, Wang X, Levey AS. Effect of dietary protein intake on serum total CO2 concentration in chronic kidney disease: Modification of Diet in Renal Disease Study findings. Clin J Am Soc Nephrol. 2006;1:52–57
  21. Huang MC, Chen ME, Hung HC, et al. Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease. J Ren Nutr. 2008;18:187–194
  22. Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: Implications for muscle atrophy. J Am Soc Nephrol. 2006;17:1388–1394
  23. Mitch WE. Malnutrition: A frequent misdiagnosis for hemodialysis patients. J Clin Invest. 2002;110:437–439
  24. Movilli E, Zani R, Carli O, et al. Correction of metabolic acidosis increases serum albumin concentrations and decreases kinetically evaluated protein intake in haemodialysis patients: A prospective study. Nephrol Dial Transplant. 1998;13:1719–1722
  25. Lefebvre A, de Vernejoul MC, Gueris J, Goldfarb B, Graulet AM, Morieux C. Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int. 1989;36:1112–1118
  26. Stein A, Moorhouse J, Iles-Smith H, et al. Role of an improvement in acid-base status and nutrition in CAPD patients. Kidney Int. 1997;52:1089–1095
  27. Szeto CC, Wong TY, Chow KM, Leung CB, Li PK. Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: A randomized placebo-control trial. J Am Soc Nephrol. 2003;14:2119–2126
  28. Lofberg E, Wernerman J, Anderstam B, Bergstrom J. Correction of acidosis in dialysis patients increases branched-chain and total essential amino acid levels in muscle. Clin Nephrol. 1997;48:230–237
  29. Reaich D, Graham KA, Channon SM, et al. Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF. Am J Physiol. 1995;268:E121–E126
  30. Rustom R, Grime JS, Costigan M, et al. Oral sodium bicarbonate reduces proximal renal tubular peptide catabolism, ammoniogenesis, and tubular damage in renal patients. Ren Fail. 1998;20:371–382
  31. Ashurst IVM, Yaqoob M. A randomized trial to study the effect of bicarbonate supplementation on the rate of progression of renal failure and nutritional status in chronic kidney disease stage 4 and 5 patients. J Am Soc Nephrol. 2006;17:37A;(abstr)
  32. Roderick P, Willis NS, Blakeley S, Jones C, Tomson C. Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007;CD001890
  33. Schainuck LI, Striker GE, Cutler RE, Benditt EP. Structural-functional correlations in renal disease. II. The correlations. Hum Pathol. 1970;1:631–641
  34. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation (Modification of Diet in Renal Disease Study Group). Ann Intern Med. 1999;130:461–470
  35. Kirschbaum B. Spurious metabolic acidosis in hemodialysis patients. Am J Kidney Dis. 2000;35:1068–1071

 Originally published online as doi: 10.1053/j.ajkd.2009.02.014 on April 27, 2009.

PII: S0272-6386(09)00511-3

doi: 10.1053/j.ajkd.2009.02.014

American Journal of Kidney Diseases
Volume 54, Issue 2 , Pages 270-277 , August 2009

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