Plasma and Peritoneal Dialysate Levels During Daptomycin Therapy for Peritonitis

(A) Peritoneal dialysis fluid and (B) blood trough concentrations of daptomycin in a patient with Gram-positive peritoneal dialysis–associated peritonitis. Daptomycin was given intravenously at a dose of 5 mg/kg body weight every 48 hours (open arrows). Peritoneal dialysis fluid was collected at the end of 3 daytime 4-hour periods (2 L Physioneal^® 2.27% each) and 1 overnight 12-hour dwell time (2 L Extraneal^® 7.5% per day). Daptomycin concentrations were measured by using high-performance liquid chromatography.⁶ The patient's hospital discharge is indicated.