American Journal of Kidney Diseases
Volume 54, Issue 3 , Pages 522-532 , September 2009

Potential Role of Soluble ST2 Protein in Idiopathic Nephrotic Syndrome Recurrence Following Kidney Transplantation

  • Sarah Bruneau

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Ludmilla Le Berre, PhD

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Caroline Hervé, PhD

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Asta Valanciuté, PhD

      Affiliations

    • INSERM U841 Eq 21, Hôpital Henri Mondor, Créteil, France
    • ,
  • Maud Kamal, PhD

      Affiliations

    • INSERM U841 Eq 21, Hôpital Henri Mondor, Créteil, France
    • ,
  • Jeanne Naulet

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Laurent Tesson

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Yohann Foucher, PhD

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Jean-Paul Soulillou, MD

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • ,
  • Djillali Sahali, MD, PhD

      Affiliations

    • INSERM U841 Eq 21, Hôpital Henri Mondor, Créteil, France
    • ,
  • Jacques Dantal, MD, PhD

      Affiliations

    • INSERM U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation (ITERT) Nantes, Université de Nantes, Faculté de Médecine, Nantes, France
    • Corresponding Author InformationAddress correspondence to Jacques Dantal, MD, PhD, ITERT/INSERM U643, CHU Hôtel Dieu, 30 Bd Jean Monnet, 44093 Nantes cedex 1 - France

Received 19 November 2008 ,Accepted 20 March 2009.

References 

  1. Pollak MR. Focal segmental glomerulosclerosis: Recent advances. Curr Opin Nephrol Hypertens. 2008;17:138–142
  2. Dantal J, Baatard R, Hourmant M, Cantarovich D, Buzelin F, Soulillou JP. Recurrent nephrotic syndrome following renal transplantation in patients with focal glomerulosclerosis (A one-center study of plasma exchange effects). Transplantation. 1991;52:827–831
  3. Pinto J, Lacerda G, Cameron JS, Turner DR, Bewick M, Ogg CS. Recurrence of focal segmental glomerulosclerosis in renal allografts. Transplantation. 1981;32:83–89
  4. Savin VJ, Sharma R, Sharma M, et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med. 1996;334:878–883
  5. Dantal J, Bigot E, Bogers W, et al. Effect of plasma protein adsorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome. N Engl J Med. 1994;330:7–14
  6. Valanciute A, le Gouvello S, Solhonne B, et al. NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome. J Immunol. 2004;172:688–698
  7. Lecart S, Lecointe N, Subramaniam A, et al. Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol. 2002;32:2979–2987
  8. Lohning M, Stroehmann A, Coyle AJ, et al. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci U S A. 1998;95:6930–6935
  9. Coyle AJ, Lloyd C, Tian J, et al. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med. 1999;190:895–902
  10. Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels RA. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest. 2000;106:551–559
  11. Gajewska BU, Swirski FK, Alvarez D, et al. Temporal-spatial analysis of the immune response in a murine model of ovalbumin-induced airways inflammation. Am J Respir Cell Mol Biol. 2001;25:326–334
  12. Cheung W, Wei CL, Seah CC, Jordan SC, Yap HK. Atopy, serum IgE, and interleukin-13 in steroid-responsive nephrotic syndrome. Pediatr Nephrol. 2004;19:627–632
  13. Mundel P, Reiser J, Zuniga Mejia Borja A, et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res. 1997;236:248–258
  14. Hattori M, Akioka Y, Chikamoto H, et al. Increase of integrin-linked kinase activity in cultured podocytes upon stimulation with plasma from patients with recurrent FSGS. Am J Transplant. 2008;8:1550–1556
  15. Le Berre L, Godfrin Y, Gunther E, et al. Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo/Mna rats. J Clin Invest. 2002;109:491–498
  16. Kuroiwa K, Arai T, Okazaki H, Minota S, Tominaga S. Identification of human ST2 protein in the sera of patients with autoimmune diseases. Biochem Biophys Res Commun. 2001;284:1104–1108
  17. Coward RJ, Foster RR, Patton D, et al. Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol. 2005;16:629–637
  18. Hoyer JR, Vernier RL, Najarian JS, Raij L, Simmons RL, Michael AF. Recurrence of idiopathic nephrotic syndrome after renal transplantation. Lancet. 1972;2:343–348
  19. Shalhoub RJ. Pathogenesis of lipoid nephrosis: A disorder of T-cell function. Lancet. 1974;2:556–560
  20. Xu D, Chan WL, Leung BP, et al. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med. 1998;187:787–794
  21. Yanagisawa K, Naito Y, Kuroiwa K, et al. The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. J Biochem (Tokyo). 1997;121:95–103
  22. Yap HK, Cheung W, Murugasu B, Sim SK, Seah CC, Jordan SC. Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: Evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol. 1999;10:529–537
  23. Grimbert P, Valanciute A, Audard V, et al. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. J Exp Med. 2003;198:797–807
  24. Sahali D, Pawlak A, Valanciute A, et al. A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening. J Am Soc Nephrol. 2002;13:1238–1247
  25. Godfrin Y, Dantal J, Perretto S, et al. Study of the in vitro effect on glomerular albumin permselectivity of serum before and after renal transplantation in focal segmental glomerulosclerosis. Transplantation. 1997;64:1711–1715
  26. Dall'Amico R, Ghiggeri G, Carraro M, et al. Prediction and treatment of recurrent focal segmental glomerulosclerosis after renal transplantation in children. Am J Kidney Dis. 1999;34:1048–1055
  27. Shimpo M, Morrow DA, Weinberg EO, et al. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004;109:2186–2190
  28. Brunner M, Krenn C, Roth G, et al. Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma. Intensive Care Med. 2004;30:1468–1473
  29. Tajima S, Oshikawa K, Tominaga S, Sugiyama Y. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Chest. 2003;124:1206–1214
  30. Oshikawa K, Kuroiwa K, Tago K, et al. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med. 2001;164:277–281

 Originally published online as doi: 10.1053/j.ajkd.2009.03.021 on June 11, 2009.

 D.S. and J.D. contributed equally to this work.

PII: S0272-6386(09)00710-0

doi: 10.1053/j.ajkd.2009.03.021

American Journal of Kidney Diseases
Volume 54, Issue 3 , Pages 522-532 , September 2009

Article Tools

* Image Usage & Resolution