American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 602-609 , October 2009

Forced Euvolemic Diuresis With Mannitol and Furosemide for Prevention of Contrast-Induced Nephropathy in Patients With CKD Undergoing Coronary Angiography: A Randomized Controlled Trial

  • Sumit R. Majumdar, MD, MPH

      Affiliations

    • Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    • EPICORE Center, University of Alberta, Edmonton, Alberta, Canada
    • Corresponding Author InformationAddress correspondence to Sumit R. Majumdar, MD, MPH, Department of Medicine, University of Alberta, 2E3.07 Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440-112th St, Edmonton, Alberta, Canada T6G 2B7
    • ,
  • Carl M. Kjellstrand, MD, PhD

      Affiliations

    • Department of Medicine, University of Loyola, Chicago, IL
    • ,
  • Wayne J. Tymchak, MD

      Affiliations

    • Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Marilou Hervas-Malo, MSc

      Affiliations

    • EPICORE Center, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Dylan A. Taylor, MD

      Affiliations

    • Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Koon K. Teo, MBBCh, PhD

      Affiliations

    • Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Received 27 December 2008 ,Accepted 27 March 2009.

References 

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  2. Parfrey PS, Griffiths SM, Barret BJ, et al. Contrast material induced renal failure in patients with diabetes mellitus, renal insufficiency, or both: A prospective controlled study. N Engl J Med. 1989;320:143–149
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  12. Dussol B, Morange S, Loundoun A, Auquier P, Berland Y. A randomized trial of saline hydration to prevent contrast nephropathy in chronic renal failure patients. Nephrol Dial Transplant. 2006;21:2120–2126
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  19. Bassler D, Montori VM, Briel M, Glasziou P, Guyatt G. Early stopping of randomized clinical trials for overt efficacy is problematic. J Clin Epidemiol. 2008;61:241–246
  20. Hewitt C, Mitchell N, Torgerson D. Heed the data when results are not significant. BMJ. 2008;336:23–25
  21. Ho KM, Sheridan DJ. Meta-analysis of frusemide to prevent or treat acute renal failure. BMJ. 2006;333:420–426
  22. Barrett BJ, Parfrey PS. Preventing nephropathy induced by contrast medium. N Engl J Med. 2006;354:379–386

 Originally published online as doi: 10.1053/j.ajkd.2009.03.024 on June 18, 2009.

 Trial registration: www.ClinicalTrials.gov; study number: NCT00175227.

PII: S0272-6386(09)00722-7

doi: 10.1053/j.ajkd.2009.03.024

American Journal of Kidney Diseases
Volume 54, Issue 4 , Pages 602-609 , October 2009

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