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Volume 54, Issue 6 , Pages 1162-1166 , December 2009

Young Man With Kidney Failure and Hemorrhagic Interstitial Nephritis

Anja Große Lordemann, MD
- Clinic of Pediatric Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- Address correspondence to Anja Große Lordemann, MD, Clinic of Pediatric Nephrology, University Hospital Essen, Hufelandstr 55, 45147 Essen, Germany
Brian Hjelle, MD
- Department of Pathology, Departments of Pathology, Biology, and Molecular Genetics & Microbiology, University of New Mexico, Albuquerque, NM
Dirk Theegarten, MD
- Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Florian Grabellus, MD
- Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Kurt Werner Schmid, MD
- Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Peter F. Hoyer, MD
- Clinic of Pediatric Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Udo Vester, MD
- Clinic of Pediatric Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Jan U. Becker, MD
- Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- Institute of Pathology, Hannover Medical School, Hannover, Germany

Received 3 December 2008 ,Accepted 17 April 2009.

Tubulointerstitial hemorrhage and infiltrate in the medulla (upper core); the cortex (lower core) shows no hemorrhage, only widened tubular lumina indicative of acute tubular damage (hematoxylin and e

Tubulointerstitial hemorrhage and infiltrate in the medulla (upper core); the cortex (lower core) shows no hemorrhage, only widened tubular lumina indicative of acute tubular damage (hematoxylin and eosin stain; original magnification ×25).
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Medulla with congested and ruptured capillaries, edema, interstitial hemorrhage, and moderate infiltrate of lymphocytes, plasma cells, neutrophils, and few eosinophils. Note the absence of intraepithe

Medulla with congested and ruptured capillaries, edema, interstitial hemorrhage, and moderate infiltrate of lymphocytes, plasma cells, neutrophils, and few eosinophils. Note the absence of intraepithelial infiltrates (hematoxylin and eosin stain; original magnification ×200).
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Virtually normal glomerulus and preglomerular vessel (left). Cortical tubules with flattened epithelium and attenuated brush border indicating acute tubular damage. Note the absence of hemorrhage and

Virtually normal glomerulus and preglomerular vessel (left). Cortical tubules with flattened epithelium and attenuated brush border indicating acute tubular damage. Note the absence of hemorrhage and inflammatory infiltrates in this portion of the midcortex (periodic acid–Schiff stain; original magnification ×200).
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